Enterprise architecture,IT effectiveness and the mediating role of IT alignment in US hospitals

Despite the possible benefits of implementing healthcare information technologies, successful implementation of effective healthcare information technology is constrained by cultural and regulatory concerns and technical obstacles encountered when establishing or upgrading an organisation's enterprise infrastructure. In this paper, we advance Ross' four‐stage model of enterprise architecture maturity as a valuable IT resource for helping healthcare organisations sustain a competitive advantage. We use partial least squares (PLS) structural equation modelling to analyse survey data from 164 US hospitals at different stages of EA maturity. Our results provide evidence that enterprise architecture maturity directly influences the effectiveness of hospitals' IT resources for achieving strategic goals. Further, enterprise architecture maturity indirectly influences the effectiveness of IT resources when IT alignment is incorporated as a mediating variable. We discuss the implications of our findings for research and practice and suggest opportunities for future research.     

Flavonoids of “La Alcarria” honey A study of their botanical origin

Summary The flavonoids present in ten selected samples of La Alcarria honey with different pollen compositions have been HPLC analysed in order to establish if correlations between botanical origin and flavonoid profiles are possible. A common flavonoid pattern is observed in the different samples showing that pollen is not the main source of honey flavonoids. A close correlation between the flavonoid patterns of honey flavonoids and propolis flavonoids has been found suggesting that flavonoid analysis could be more useful in geographical origin determinations than in botanical origin studies.

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Flavonoide des La-Alcarria-Honigs Eine Studie ihres botanischen Ursprungs

Zusammenfassung Die Flavonoide in Proben in Alcarria-Honig mit unterschiedlicher Pollenzusammensetzung wurden untersucht, um Kortrelationen zwischen dem botanischen Ursprung und den möglichen Flavonoiden zu finden. In den verschiedenen Proben wurde ein Flavonoid-Muster gefunden, wobei der Pollen nicht die Hauptquelle der Honigflavonoide ist. Es wurde jedoch eine enge Korrelation zwischen den Flavonoid-Mustern des Honigs und des Bienenkittharzes gefunden, was für die geographische Herkunft wichtiger ist als die botanische.

     

Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.     

Size distribution functions of dispersions

The size distribution function of bubbles in thermodynamic equilibrium with the surrounding liquid has been derived in the absence of gravity. The derivation has been based on the assumption that the gas is dispersed into bubbles in a completely random way in respect of the energies of the bubbles. The size distribution function of bubbles obtained when surface tension effects are neglected is of the same form as the empirical Nukiyama-Tanasawa distribution, and gives also the size distribution function of droplets consisting of an incompressible liquid when the way the liquid is dispersed into droplets is assumed to be completely random with respect to the volumes of the droplets. The derived size distribution functions agree well with the experimental size distributions of bubbles in water having been generated by an air entrainment process at the surface of the water or behind a ventilated body.     

Activity coefficients of Na2O in molten NaCl,Na2SO4, and Na2CO3

Measurements of the cell

have been used to determine activity coefficients of Na₂O in molten NaCl, Na₂SO₄ and Na₂CO₃. Extreme negative deviations from Raoult's law were observed (γ < 10^?3). In NaCl and Na₂SO₄, γ is independent of concentration below 1 m/o Na₂O, but in Na₂CO₃, the activity is nearly independent of concentration, probably because the oxide reacts with dissolved O₂ to form superoxide (O^?₂).     

Adaptive signal processing of asset price dynamics with predictability analysis

In this paper we illustrate the optimal filtering of log returns of commodity prices in which both the mean and volatility are modulated by a hidden Markov chain with finite state space. The optimal estimate of the Markov chain and the parameters of the price model are given in terms of discrete-time recursive filters. We provide an application on a set of high frequency gold price data for the period 1973-2006 and analyse the h-step ahead price predictions against the Diebold-Kilian metric. Within the modelling framework where the mean and volatility are switching regimes, our findings suggest that a two-state hidden Markov model is sufficient to describe the dynamics of the data and the gold price is predictable up to a certain extent in the short term but almost impossible to predict in the long term. The proposed model is also benchmarked with ARCH and GARCH models with respect to price predictability and forecasting errors.     

General restoration filter for vibrated-image restoration

Mechanical vibrations are often the principal cause of image degradation. Low temporal-frequency mechanical vibrations involve random image degradation that depends on the instant of exposure. Exact restoration requires the calculation of a specific filter unique to each vibrated image. To calculate the restoration filter for each image, one needs the specific optical transfer function unique to the motion in the image. Therefore the instant of exposure and the motion function have to be measured or estimated by some other means. We develop a restoration filter for individual images blurred randomly by low-frequency mechanical vibrations. The filter is independent of the instant of exposure. The filter is designed to give its best performance averaged over a complete ensemble of vibrated images. Although when applying the new filter to any vibrated image the restoration achieved is slightly poorer than that achieved with an exact filter unique to the specific motion function, the new filter has the advantage of simplicity.     

Speckle noise in laser bar-code-scanner systems

We present a theoretical model and its experimental verification for speckle-induced noise in laser-based bar-code-scanner systems. We measured the dependence of the signal-to-speckle-noise ratio on distance, spot size, and detector size. Analyses of the power spectra of both the speckle noise and of the measured surface profiles of different substrates suggest that the paper surface granularity can be approximated by a white Gaussian noise process, thus confirming the assumption of the theoretical model.