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91.
Audrey Vandomme Aline Fréville Katia Cailliau Hadidjatou Kalamou Jean-Fran?ois Bodart Jamal Khalife Christine Pierrot 《International journal of molecular sciences》2014,15(2):2431-2453
In Plasmodium falciparum (Pf), the causative agent of the deadliest form of malaria, a tight regulation of phosphatase activity is crucial for the development of the parasite. In this study, we have identified and characterized PfPTPA homologous to PhosphoTyrosyl Phosphatase Activator, an activator of protein phosphatase 2A which is a major phosphatase involved in many biological processes in eukaryotic cells. The PfPTPA sequence analysis revealed that five out of six amino acids involved in interaction with PP2A in human are conserved in P. falciparum. Localization studies showed that PfPTPA and PfPP2A are present in the same compartment of blood stage parasites, suggesting a possible interaction of both proteins. In vitro binding and functional studies revealed that PfPTPA binds to and activates PP2A. Mutation studies showed that three residues (V283, G292 and M296) of PfPTPA are indispensable for the interaction and that the G292 residue is essential for its activity. In P. falciparum, genetic studies suggested the essentiality of PfPTPA for the completion of intraerythrocytic parasite lifecycle. Using Xenopus oocytes, we showed that PfPTPA blocked the G2/M transition. Taken together, our data suggest that PfPTPA could play a role in the regulation of the P. falciparum cell cycle through its PfPP2A regulatory activity. 相似文献
92.
Christine Bernardi Tomás Chacón Rebollo Marco Restelli 《Journal of scientific computing》2012,51(2):349-374
We consider the finite element discretization of a convection-diffusion equation, where the convection term is handled via
a fluctuation splitting algorithm. We prove a posteriori error estimates which allow us to perform mesh adaptivity in order
to optimize the discretization of these equations. Numerical results confirm the interest of such an approach. 相似文献
93.
94.
Dan A. Buzatu Willie M. Cooper Christine Summage-West John B. Sutherland Anna J. Williams Deborah A. Bass Lisa L. Smith Robert S. Woodruff Jessica M. Christman Steven Reid Randal K. Tucker Christopher J. Haney Ashfaqe Ahmed Fatemeh Rafii Jon G. Wilkes 《Food microbiology》2013
A flow cytometric method (RAPID-B™) with detection sensitivity of one viable cell of Escherichia coli serotype O157:H7 in fresh spinach (Spinacia oleracea) was developed and evaluated. The major impediment to achieving this performance was mistaking autofluorescing spinach particles for tagged target cells. Following a 5 h non-selective enrichment, artificially inoculated samples were photobleached, using phloxine B as a photosensitizer. Samples were centrifuged at high speed to concentrate target cells, then gradient centrifuged to separate them from matrix debris. In external laboratory experiments, RAPID-B and the reference method both correctly detected E. coli O157:H7 at inoculations of ca. 15 cells. In a follow-up study, after 4 cell inoculations of positives and 6 h enrichment, RAPID-B correctly identified 92% of 25 samples. The RAPID-B method limit of detection (LOD) was one cell in 25 g. It proved superior to the reference method (which incorporated real time-PCR, selective enrichment, and culture plating elements) in accuracy and speed. 相似文献
95.
Chiarello Christine; Welcome Suzanne E.; Halderman Laura K.; Towler Stephen; Julagay Janelle; Otto Ronald; Leonard Christiana M. 《Canadian Metallurgical Quarterly》2009,23(2):210
The authors report findings of a large-scale, multitask investigation of sex differences in both structural asymmetries and lateralization of word reading. Two hundred participants were tested in eight divided visual field lexical tasks, and each received a structural magnetic resonance imaging scan. The authors examined whether there was evidence for sex differences in overall measures of neuroanatomical and behavioral lateralization, in specific language tasks and brain regions, and in variation in asymmetry within and across tasks and brain regions. There was very little evidence for sex differences on any behavioral measure. The few indications of sex differences in the current report accounted for 2% or less of the individual variation in asymmetry and could not be replicated in independent subsamples. No sex differences were observed in the asymmetry of structures in Broca's and Wernicke's areas such as pars triangularis, pars opercularis, the planum temporale, planum parietale, or Heschl's gyrus. There were also no sex differences in the variability of neuroanatomical asymmetries within or between brain regions. However, a significant relationship between planum temporale and behavioral asymmetry was restricted to men. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
96.
The nature of polymer grafts and substrate shape on the surface degradation of poly(l‐lactide) 下载免费PDF全文
Robertus Wahyu N. Nugroho Karin Odelius Anders Höglund Ann‐Christine Albertsson 《应用聚合物科学杂志》2015,132(47)
Surface grafting of functional polymers is an effective method to alter material properties and degradation behavior. Two different substrate shapes of poly(l ‐lactide) (PLLA), i.e., films and microparticles, were surface‐grafted with hydrophilic monomers, and their surface degradation was monitored. Surface grafting with a hydrophilic and acidic polymer graft [acrylic acid (AA)] induced large alterations in the surface morphology and topography of the films. In contrast, hydrophilic and neutral polymer grafts [acrylamide (AAm)] had no significant effect on the surface degradation behavior, while the PLLA reference and co‐monomeric (AA/AAm) polymer‐grafted samples exhibited intermediate surface degradation rates. The grafted PAA chains induced a local acidic environment on the surface of the substrates, which in turn catalyzed the surface degradation process. This effect was more pronounced in the films than in the microparticles. Thus, the nature of the grafted chains and substrate geometry were shown to affect the surface degradation behavior of PLLA substrates. © 2015 The Authors Journal of Applied Polymer Science Published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42736. 相似文献
97.
Tuan-Hiep Pham Van-Xuan Tran Gaëlle Chretien Catherine Gardin Christine Sarrazin-Baudoux Jean Petit 《Journal of Materials Science》2015,50(1):242-250
In this paper, the near-threshold fatigue behavior of physically through-thickness short cracks and of long cracks in a low alloy steel is investigated by experiments in ambient air. Physically through-thickness short fatigue cracks are created by gradually removing the plastic wake of long cracks in compact tension specimens. The crack closure is systematically measured using the compliance variation technique with numerical data acquisition and filtering for accurate detection of the stress intensity factor (SIF) at the crack opening. Based on the experimental results, the nominal threshold SIF range is shown to be dependent on the crack length and the characteristic of the crack wake which is strongly dependent on the loading history. The effective threshold SIF range and the relation between the crack propagation rate and the effective SIF range after the crack closure correction are shown to be independent on crack length and loading history. The shielding effect of the crack closure is shown to be related to the wake length and load history. The effective threshold SIF range and the relationship between the crack growth rate and the effective SIF range appear to be unique for this material in ambient air. These properties can be considered as specific fatigue properties of the couple material/ambient air environment. 相似文献
98.
Christine M. Wickens Evelyn Vingilis Robert E. Mann Patricia Erickson Maggie E. Toplak Nathan J. Kolla Jane Seeley Anca R. Ialomiteanu Gina Stoduto Gabriela Ilie 《Accident; analysis and prevention》2015
Background
Despite limited empirical investigation, existing scientific literature suggests that individuals with a history or current diagnosis of conduct disorder (CD) may be more likely to demonstrate reckless and aggressive driving. Much of the limited research in this field examines the impact of childhood CD on driver behaviour and collision risk in young adults. Few if any, studies assess the impact of this disorder on driver behaviour beyond age 21 years. The current research is a population-based study of the impact of CD symptoms during childhood on the risk of engaging in driver aggression during adulthood.Methods
Data are based on telephone interviews with 5230 respondents who reported having driven in the past year. Data are derived from the 2011–2013 cycles of the CAMH Monitor, an ongoing cross-sectional survey of adults in Ontario, Canada aged 18 years and older. A binary logistic regression analysis of self-reported driver aggression in the previous 12 months was conducted, consisting of measures of demographic characteristics, driving exposure, problem substance use, alcohol- and drug-impaired driving, symptoms of attention deficit hyperactivity disorder, and childhood (before age 15) symptoms of CD.Results
When entered with demographic characteristics, driving exposure, and other potential confounders, childhood symptoms of CD increased the odds of reporting driver aggression more than two-fold (adjusted OR = 2.12). Exploratory analyses of the interaction between childhood symptoms of CD and age was not a significant predictor of driver aggression.Conclusions
Results suggest that symptoms of CD during childhood are associated with significantly increased odds of self-reported driver aggression during adulthood. Limitations and future directions of the research are discussed. 相似文献99.
Visualization Approaches for Evaluating Ridge Regression Estimators in Mixture and Mixture‐Process Experiments 下载免费PDF全文
Dae‐Heung Jang Christine M. Anderson‐Cook 《Quality and Reliability Engineering International》2015,31(8):1483-1494
When the component proportions in mixture experiments are restricted by lower and upper bounds, the input space of a designed experiment space can become an irregular region that can induce multicollinearity problems when estimating the component proportion parameters. Thus, ridge regression provides a beneficial means of stabilizing the coefficient estimates in the fitted model. Previous research has focused on using prediction variance as a metric for determining an appropriate value of the ridge constant, k. We use visualization techniques to illustrate and evaluate ridge regression estimators and the robustness of estimation with respect to the variance and the bias. The addition of bias allows better balancing between the stability of the estimators and minimally changing the estimates. We illustrate the graphical methods with mixture and mixture‐process examples from the literature. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
100.
Nick Blismas Christine Pasquire Alistair Gibb 《Construction Management & Economics》2013,31(2):121-130
Evaluating to what extent a component or building system should be produced off‐site is inadequate within the industry. The potential benefits of off‐site production (OSP) are commonly cited when justifying an OSP approach, yet holistic and methodical assessments of the applicability and overall benefit of these solutions, to a particular project, have been found to be deficient. Common methods of evaluation simply take material, labour and transportation costs into account when comparing various options, often disregarding other cost‐related items such as site facilities, crane use and rectification of works. These cost factors are usually buried within the nebulous preliminaries figure, with little reference to the building approach taken. Further, softer issues such as health and safety, effects on management and process benefits are either implicit or disregarded within these comparison exercises. Yet it is demonstrated that these issues are some of the most significant benefits of OSP. A series of case studies demonstrated that evaluation focus is almost solely on direct material and labour costs of components, without explicit regard for the wider cost or soft issue implications of OSP on a project. The paper argues that until evaluation is more holistic and value‐based rather than cost‐based, OSP uptake in construction will be slow. 相似文献