Experience with a Hybrid Processor: K-Means Clustering

We discuss hardware/software co-processing on a hybrid processor for a compute- and data-intensive multispectral imaging algorithm, k-means clustering. The experiments are performed on two models of the Altera Excalibur board, the first using the soft IP core 32-bit NIOS 1.1 RISC processor, and the second with the hard IP core ARM processor. In our experiments, we compare performance of the sequential k-means algorithm with three different accelerated versions. We consider granularity and synchronization issues when mapping an algorithm to a hybrid processor. Our results show that speedup of 11.8X is achieved by migrating computation to the Excalibur ARM hardware/software as compared to software only on a Gigahertz Pentium III. Speedup on the Excalibur NIOS is limited by the communication cost of transferring data from external memory through the processor to the customized circuits. This limitation is overcome on the Excalibur ARM, in which dual-port memories, accessible to both the processor and configurable logic, have the biggest performance impact of all the techniques studied.     

三相异步电机新模型及其仿真与实验

介绍了三相异步电机的一个新模型。新模型由原始的相轴线模型经过变换得到。该模型可应用在电机定子三相参数不对称的状态。计算机仿真和电机模拟实验表明：在派克方程适用范围，新模型与PARK模型的响应完全一致：当电机定子三相参数不对称时，此时已超出PARK模型的适用范围，新模型的仿真计算结果与电机的实验数据相当吻合。新模型具有比PARK模型更广的适用范围。该模型在三相异步电机的监测及控制方面有广泛的应用前景。     

Metallic Conductive Nanowires Elaborated by PVD Metal Deposition on Suspended DNA Bundles

Metallic conductive nanowires (NWs) with DNA bundle core are achieved, thanks to an original process relying on double‐stranded DNA alignment and physical vapor deposition (PVD) metallization steps involving a silicon substrate. First, bundles of DNA are suspended with a repeatable process between 2 µm high parallel electrodes with separating gaps ranging from 800 nm to 2 µm. The process consists in the drop deposition of a DNA lambda‐phage solution on the electrodes followed by a naturally evaporation step. The deposition process is controlled by the DNA concentration within the buffer solution, the drop volume, and the electrode hydrophobicity. The suspended bundles are finally metallized with various thicknesses of titanium and gold by a PVD e‐beam evaporation process. The achieved NWs have a width ranging from a few nanometers up to 100 nm. The electrical behavior of the achieved 60 and 80 nm width metallic NWs is shown to be Ohmic and their intrinsic resistance is estimated according to different geometrical models of the NW section area. For the 80 nm width NWs, a resistance of about few ohms is established, opening exploration fields for applications in microelectronics.     

A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease,Frontotemporal Dementia,and Subjective Cognitive Decline,and the Evaluation of Candidate Proteins for Immunoassay Calibration

Neurofilament light chain (Nf-L) is a well-known biomarker for axonal damage; however, the corresponding circulating Nf-L analyte in cerebrospinal fluid (CSF) is poorly characterized. We therefore isolated new monoclonal antibodies against synthetic peptides, and these monoclonals were characterized for their specificity on brain-specific intermediate filament proteins. Two highly specific antibodies, ADx206 and ADx209, were analytically validated for CSF applications according to well-established criteria. Interestingly, using three different sources of purified Nf-L proteins, a significant impact on interpolated concentrations was observed. With a lower limit of analytical sensitivity of 100 pg/mL using bovine Nf-L as the calibrator, we were able to quantify the Nf-L analyte in each sample, and these Nf-L concentrations were highly correlated to the Uman diagnostics assay (Spearman rho = 0.97, p < 0.001). In the clinical diagnostic groups, the new Nf-L ELISA could discriminate patients with Alzheimer’s disease (AD, n = 20) from those with frontotemporal lobe dementia (FTD, n = 20) and control samples with subjective cognitive decline (SCD, n = 20). Henceforth, this novel Nf-L ELISA with well-defined specificity and epitopes can be used to enhance our understanding of harmonizing the use of Nf-L as a clinically relevant marker for neurodegeneration in CSF.     

Introduction to the Special Issue on Meta-Learning

Recent advances in meta-learning are providing the foundations to construct meta-learning assistants and task-adaptive learners. The goal of this special issue is to foster an interest in meta-learning by compiling representative work in the field. The contributions to this special issue provide strong insights into the construction of future meta-learning tools. In this introduction we present a common frame of reference to address work in meta-learning through the concept of meta-knowledge. We show how meta-learning can be simply defined as the process of exploiting knowledge about learning that enables us to understand and improve the performance of learning algorithms.     

Chelating Polymers for Targeted Decontamination of Actinides: Application of PEI-MP to Hydroxyapatite-Th(IV)

In case of an incident in the nuclear industry or an act of war or terrorism, the dissemination of plutonium could contaminate the environment and, hence, humans. Human contamination mainly occurs via inhalation and/or wounding (and, less likely, ingestion). In such cases, plutonium, if soluble, reaches circulation, whereas the poorly soluble fraction (such as small colloids) is trapped in alveolar macrophages or remains at the site of wounding. Once in the blood, the plutonium is delivered to the liver and/or to the bone, particularly into its mineral part, mostly composed of hydroxyapatite. Countermeasures against plutonium exist and consist of intravenous injections or inhalation of diethylenetetraminepentaacetate salts. Their effectiveness is, however, mainly confined to the circulating soluble forms of plutonium. Furthermore, the short bioavailability of diethylenetetraminepentaacetate results in its rapid elimination. To overcome these limitations and to provide a complementary approach to this common therapy, we developed polymeric analogs to indirectly target the problematic retention sites. We present herein a first study regarding the decontamination abilities of polyethyleneimine methylcarboxylate (structural diethylenetetraminepentaacetate polymer analog) and polyethyleneimine methylphosphonate (phosphonate polymeric analog) directed against Th(IV), used here as a Pu(IV) surrogate, which was incorporated into hydroxyapatite used as a bone model. Our results suggest that polyethylenimine methylphosphonate could be a good candidate for powerful bone decontamination action.     

Compressive and Tensile Behaviours of PLLA Matrix Composites Reinforced with Randomly Dispersed Flax Fibres

Nowadays, the ecological footprint of a material is becoming tremendously important. The Poly l-Lactide Acid (PLLA) matrix composites reinforced by randomly scattered flax fibres have mechanical properties similar to polyester/glass composites [1], lower environmental impacts and can be compost at the end of their lives. In this study, the mechanical characterization of biocomposites has been pushed further with the determination of the compressive and tensile properties. Furthermore, the mechanical properties of single flax fibres have been measured and implemented in a micro-mechanical estimation of the composite elastic modulus. Tensile and compressive stiffness determined by the mechanical analyses show very good correlations with the mathematical estimation.     

Multiproject lineage management: Bridging project management and design-based innovation strategy

Innovation-based strategies are widely recognized as key drivers to maintain competitive advantage. The design and strategic literature underline the possibility of triggering a multiproduct value-expansion dynamic based on the creation of new concepts dynamically twinned with corporate strategy. However, the multiproject-management literature—portfolio, program, and platform—lags behind and remains focused on ex ante coordination, resource allocation and selectionism. Thus, there are still few indications of the processes that stimulate and orient continuous, profitable multiproject creative expansion. Bridging the multiproject-management literature and design theory, we propose a model of multiproject lineage management (MPLM), which focuses on the key processes that drive exploration efforts and shape innovation trajectory. We conduct a multiple longitudinal case analysis in the automobile sector. Based on this analysis, we expose the principles of MPLM, mapping the roles of corporate, program and project management within a global expansion project. Finally, we highlight our contributions to managerial practices and the related literature.