Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery

Although gas-filled microbubbles with high echogenicity are widely applied inclinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors,which are accessible to objects less than several hundred nanometers. We herein propose an unusual approach involving apH-induced core–shell micelle-to-vesicle transition to prepare ultrasound-sensitive polymeric nanospheres (polymersomes in structure) possessing multiple features, including nanosize, monodispersity, and incorporation of a phase-transitional imaging agent into the aqueous lumen. These features are not achievable via the conventional double-emulsion method for polymersome preparation. The nanospheres were constructed based on a novel triblock copolymer with dual pH sensitivity. The liquid-to-gas phase transition of the imaging agent induced by external low-frequency ultrasound may destroy the nanospheres for a rapid drug release, with simultaneous tissue-penetrating drug delivery inside a tumor. These effects may provide new opportunities for the development of an effective cancer therapy with few adverse effects.

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美国一流大学计算机组成与系统结构实验课程研究

文章针对美国一流大学的计算机组成与系统结构实验课程进行研究,重点介绍UC Berkeley,MIT,Stanford University,CMU相关实验课程的内容和特色,为我国大学计算机组成与系统结构实验课程今后的改革与发展提供参考。     

平均保障延误时间（MLDT）建模方法研究

针对现代装备系统的精确化保障要求,对装备保障的主要参数指标MLDT进行了建模分析,主要分析了三种计算方法：图估法、解析法和基于排队论的MLDT建模理论,解决了评估MLDT指标时的定量计算问题。     

Salient structural elements based texture synthesis

Salient structural elements are ubiquitous in natural textures, and their distribution exhibits some stochastic distribution features. Current texture synthesis algorithms can neither preserve the integrity of the elements nor capture this distributive information. We present an algorithm to treat this high-level visual information. Here, we address the issue by taking specific care of the structural elements. Our texture synthesis process grows the target texture one structural element at a time. A Markov ...     

Optimized element positions for prescribed radar cross section pattern of linear dipole arrays

Approximate closed‐form expression is derived for the scattering from dipole arrays based on the equivalent circuit theory. Then, a method is proposed for synthesis of dipole arrays to produce desired scattering pattern using genetic algorithm (GA). In the synthesis method, the element positions in an array are considered as the optimization parameter and the derived expression is used to evaluate the fitness function of GA. To assess the validity and efficiency of the proposed method, several linear dipole arrays are designed to obtain scattering pattern with low sidelobe level (SLL). A good agreement between the patterns calculated using the expression and simulated by FEKO validates the accuracy of the presented expression. In addition, the numerical results show that the maximum SLL of the scattering pattern is considerably reduced by optimization. © 2011 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2011.     

A tree-based particle swarm optimization for multicast routing

QoS multicast routing is a non-linear combinatorial optimization problem. It tries to find a multicast routing tree with minimal cost that can satisfy constraints such as bandwidth, delay, and delay jitter. This problem is NP-complete. The solution to such problems is often to search first for paths from the source node to each destination node and then integrate these paths into a multicast tree. Such a method, however, is slow and complex. To overcome these shortcomings, we propose a new method for tree-based optimization. Our algorithm optimizes the multicast tree directly, unlike the conventional solutions to finding paths and integrating them to generate a multicast tree. Our algorithm also applies particle swarm optimization to the solution to control the optimization orientation of the tree shape. Simulation results show that our algorithm performs well in searching, converging speed and adaptability scale.     

北斗2代卫星导航电文纠错校验设计与仿真

提出了一种制表映射的BCH纠错解码和校验方法,通过对RNSS-ICD文档北斗导航电文BCH编码的深入理解,设计出了一种占用CPU资源少、实现简单方便的制表映射的编码和纠错解码算法,减小了算法在实现时对CPU和内存资源的占用;给出了一种再编码校验的校验方法仿真验证了该算法的准确性和可靠性,保证导航电文的可靠性;对提高接收机的性能具有很强的工程适用价值.     

软件测试课程建设的几点措施

分析软件测试课程的教学背景,从教学内容、教学资源、教学方法、实践方法、师资建设等方面对软件测试课程的教学改革进行探讨,提出课程建设的具体措施,以期对高校软件测试课程建设具有参考意义。     

Evaluating the influence of E-marketing on hotel performance by DEA and grey entropy

This study evaluated the hotels’ websites in Taiwan from an Internet marketing perspective. Content analysis was used to analyze and compare the marketing practice on Internet. DEA and grey entropy were used to analyze the impact of Internet marketing on hotel performance. The result showed that Internet marketing can affect the operating performance of tourist hotels. Hoteliers should adopt a more strategic Internet approach to increase business success.