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41.
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Silvia Pomella Antonella Porrazzo Matteo Cassandri Simona Camero Silvia Codenotti Luisa Milazzo Francesca Vulcano Giovanni Barillari Giovanni Cenci Cinzia Marchese Alessandro Fanzani Francesca Megiorni Rossella Rota Francesco Marampon 《International journal of molecular sciences》2022,23(21)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence that includes FP-RMS, harboring the fusion oncoprotein PAX3/7-FOXO1 and FN-RMS, often mutant in the RAS pathway. Risk stratifications of RMS patients determine different prognostic groups and related therapeutic treatment. Current multimodal therapeutic strategies involve surgery, chemotherapy (CHT) and radiotherapy (RT), but despite the deeper knowledge of response mechanisms underpinning CHT treatment and the technological improvements that characterize RT, local failures and recurrence frequently occur. This review sums up the RMS classification and the management of RMS patients, with special attention to RT treatment and possible radiosensitizing strategies for RMS tumors. Indeed, RMS radioresistance is a clinical problem and further studies aimed at dissecting radioresistant molecular mechanisms are needed to identify specific targets to hit, thus improving RT-induced cytotoxicity. 相似文献
43.
Robertina Giacconi Patrizia DAquila Marta Balietti Cinzia Giuli Marco Malavolta Francesco Piacenza Laura Costarelli Demetrio Postacchini Giuseppe Passarino Dina Bellizzi Mauro Provinciali 《International journal of molecular sciences》2023,24(1)
Microbial dysbiosis (MD) provokes gut barrier alterations and bacterial translocation in the bloodstream. The increased blood bacterial DNA (BB-DNA) may promote peripheral- and neuro-inflammation, contributing to cognitive impairment. MD also influences brain-derived neurotrophic factor (BDNF) production, whose alterations contribute to the etiopathogenesis of Alzheimer’s disease (AD). The purpose of this study is to measure BB-DNA in healthy elderly controls (EC), and in patients with mild cognitive impairment (MCI) and AD to explore the effect on plasma BDNF levels (pBDNF), the inflammatory response, and the association with cognitive decline during a two-year follow-up. Baseline BB-DNA and pBDNF were significantly higher in MCI and AD than in EC. BB-DNA was positively correlated with pBDNF in AD, plasma Tumor necrosis factor-alpha (TNF-α), and Interleukin-10 (IL-10) levels in MCI. AD patients with BB-DNA values above the 50th percentile had lower baseline Mini-Mental State Examination (MMSE). After a two-year follow-up, AD patients with the highest BB-DNA tertile had a worse cognitive decline, while higher BB-DNA levels were associated with higher TNF-α and lower IL-10 in MCI. Our study demonstrates that, in early AD, the higher the BB-DNA levels, the higher the pBDNF levels, suggesting a defensive attempt; BB-DNA seems to play a role in the AD severity/progression; in MCI, higher BB-DNA may trigger an increased inflammatory response. 相似文献
44.
Summary In a Bayesian analysis, suppose that probability measures may be specified over the subsets partitioning the parameter space
Ω, in such a way that they can be combined to form a unique prior measure, defined over all Ω, according to some weights.
Should the weights be uncertain, then the class Г of all the probability measures compatible with such uncertainty is specified
instead. Situations in which such a class Г is justified are presented and, in these cases, established and quite recent techniques
in the field of robust Bayesian analysis are applied to Г. Bounds on posterior expectations are computed, as the prior measure
varies in Г, whilst concentration functions and coefficients of divergence are considered when interest lies with comparing
functional forms of measures in Г. 相似文献
45.
Iole Pitino Cinzia Lucia Randazzo Giuseppina Mandalari Alberto Lo Curto Richard Martin Faulks Yvan Le Marc Carlo Bisignano Cinzia Caggia Martin Sean John Wickham 《Food microbiology》2010
In the present study six probiotic Lactobacillus rhamnosus strains were investigated for their ability to survive in the human upper gastrointestinal tract through a dynamic gastric model of digestion. MRS broth was used as delivery vehicle and survival was investigated during in vitro gastric and gastric plus duodenal digestion. Results highlighted that all tested strains showed good survival rate during both gastric and duodenal digestion. In particular, three strains exhibited a great survival showing a recovery percentage in the range between 117 and 276%. In agreement with survival data, high lactic acid production was detected for all strains, confirming their metabolic activity during digestion. 相似文献
46.
Carlo Giorgio Visconti Enrico Tronconi Luca Lietti Gianpiero Groppi Pio Forzatti Cinzia Cristiani Roberto Zennaro Stefano Rossini 《Applied Catalysis A: General》2009,370(1-2):93-101
In principle, the application of monolithic catalysts to the Fischer–Tropsch synthesis can solve many of the problems related to the classical Fischer–Tropsch reactors, in particular concerning the necessity to operate with short diffusion distances and low pressure drops, preferably according to the ideal plug-flow behavior, while still maintaining a reasonable inventory of catalytic material in the reactor volume.The preparation of prototype cobalt-based catalysts, washcoated onto metallic structured supports with different geometries, is described herein, together with the evaluation of the catalytic properties of such systems in the Fischer–Tropsch synthesis at industrially relevant process conditions (220–235 °C, 20 bar, 2.1 molH2/molCO, 5000 cm3(STP)CO+H2/h/gcat). Comparative tests with the same catalyst in the powdered form were also carried out at the same process conditions.It was found that the structured catalysts maintained the activity and the selectivity of the original powdered catalyst, provided that the washcoat thickness is sufficiently thin. 相似文献
47.
Chiara Guglielmi Rosa Scarpitta Gaetana Gambino Eleonora Conti Francesca Bell Mariella Tancredi Tiziana Cervelli Elisabetta Falaschi Cinzia Cosini Paolo Aretini Caterina Congregati Marco Marino Margherita Patruno Brunella Pilato Francesca Spina Luisa Balestrino Elena Tenedini Ileana Carnevali Laura Cortesi Enrico Tagliafico Maria Grazia Tibiletti Stefania Tommasi Matteo Ghilli Caterina Vivanet Alvaro Galli Maria Adelaide Caligo 《International journal of molecular sciences》2021,22(14)
With the progress of sequencing technologies, an ever-increasing number of variants of unknown functional and clinical significance (VUS) have been identified in both coding and non-coding regions of the main Breast Cancer (BC) predisposition genes. The aim of this study is to identify a mutational profile of coding and intron-exon junction regions of 12 moderate penetrance genes (ATM, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53) in a cohort of 450 Italian patients with Hereditary Breast/Ovarian Cancer Syndrome, wild type for germline mutation in BRCA1/2 genes. The analysis was extended to 5′UTR and 3′UTR of all the genes listed above and to the BRCA1 and BRCA2 known regulatory regions in a subset of 120 patients. The screening was performed through NGS target resequencing on the Illumina platform MiSeq. 8.7% of the patients analyzed is carriers of class 5/4 coding variants in the ATM (3.6%), BRIP1 (1.6%), CHEK2 (1.8%), PALB2 (0.7%), RAD51C (0.4%), RAD51D (0.4%), and TP53 (0.2%) genes, while variants of uncertain pathological significance (VUSs)/class 3 were identified in 9.1% of the samples. In intron-exon junctions and in regulatory regions, variants were detected respectively in 5.1% and in 32.5% of the cases analyzed. The average age of disease onset of 44.4 in non-coding variant carriers is absolutely similar to the average age of disease onset in coding variant carriers for each proband’s group with the same cancer type. Furthermore, there is not a statistically significant difference in the proportion of cases with a tumor onset under age of 40 between the two groups, but the presence of multiple non-coding variants in the same patient may affect the aggressiveness of the tumor and it is worth underlining that 25% of patients with an aggressive tumor are carriers of a PTEN 3′UTR-variant. This data provides initial information on how important it might be to extend mutational screening to the regulatory regions in clinical practice. 相似文献
48.
The multi element profile of milk from 12 cows and 6 water buffaloes was investigated, to establish whether dairy products derived from the two species could be distinguished. Multi-element data were obtained using ICP-MS. Following assessment against the team’s QA/QC criteria, or where the levels were below the LOD for the procedure, 16 elements (P, S, K, Ca, V, Cr, Mn, Fe, Co, Zn, Ga, Rb, Sr, Mo, Cs and Ba) were submitted for statistical analysis. Using linear discriminant analysis (LDA) it was possible to differentiate between milk from the two species, produced under identical environmental and animal husbandry conditions, on one farm. The sources of food and water available for consumption by the animals were also analysed and the results showed that there was no correlation between the elemental composition of the dietary components and the profiles observed in the milk. 相似文献
49.
50.
Moschini Ugo Fenialdi Elena Daraio Cinzia Ruocco Giancarlo Molinari Elisa 《Scientometrics》2020,125(2):1145-1158
Scientometrics - In this paper, we compare the distribution of Elsevier Scopus subject areas of authors’ documents, their bibliographical references and their citing documents. We compute the... 相似文献