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21.
Jens Hauslage Medea Abbrecht Lars Hanke Ruth Hemmersbach Claudia Koch Wolfgang Hanke Florian P. M. Kohn 《Microgravity science and technology》2016,28(6):633-638
All life on earth has been established under conditions of stable gravity of 1g. Nevertheless, in numerous experiments the direct gravity dependence of biological processes has been shown on all levels of organization, from single molecules to humans. To study the effects especially of microgravity on biological systems, a variety of platforms are available, from drop towers to the ISS. Due to the costs of these platforms and their limited availability, as an alternative, numerous simulators have been developed for so called “simulated” microgravity. A classical systems is a clinostat, basically rotating a sample around one axis, and by integration of the gravity vector for 360° arguing that thus the effects of gravity are depleted. Indeed, a variety of studies has shown that taking out the direction of gravity from a biological system often results in consequences similar to the exposure of the system to real microgravity. Nevertheless, the opposite has been shown, too, and as a consequence the relevance of clinostats in microgravity research is still under discussion. To get some more insight into this problem we have constructed a small fluorescence clinostat and have studied the effects of clinorotation on the cytosolic calcium concentration of neuroglioma cells. The results have been compared to experiments with identical cells in real microgravity, utilizing parabolic flight missions. Our results show that in case of a cell suspension used in a small florescence clinostat within a tube diameter of 2mm, the effects of clinorotation are comparable to those under real microgravity, both showing a significant increase in intracellular calcium concentration. 相似文献
22.
Merle Schmahl Cecilia Müller Reinhard Meinke Erika G. Alves Alcantara Ude D. Hangen Claudia Fleck 《Advanced Engineering Materials》2023,25(10):2201676
Cyclic nanoindentation allows characterizing the influence of single phases and their interactions on fatigue mechanisms. Herein, a method for high cycle fatigue testing by nanoindentation is presented. By combining high- and low-frequency indentation modes, high cycle numbers are achieved while obtaining sufficient data points to reconstruct force–displacement hysteresis loops. A challenge is the stochastic course of thermal drift which is addressed by measuring drift rate in regular low-force holding segments. Drift rates are used to correct the displacement values, yielding reproducible cyclic deformation data as it is shown for two very different materials, a ductile metal and a brittle ceramic. 相似文献
23.
24.
Claudia Archetti Dominique Feillet Alain Hertz M. Grazia Speranza 《Computers & Operations Research》2010,37(11):1860-1869
A profit and a demand are associated with each edge of a set of profitable edges of a given graph. A travel time is associated with each edge of the graph. A fleet of capacitated vehicles is given to serve the profitable edges. A maximum duration of the route of each vehicle is also given. The profit of an edge can be collected by one vehicle only that also serves the demand of the edge. The objective of this problem, which is called the undirected capacitated arc routing problem with profits (UCARPP), is to find a set of routes that satisfy the constraints on the duration of the route and on the capacity of the vehicle and maximize the total collected profit. We propose a branch-and-price algorithm and several heuristics. We can solve exactly instances with up to 97 profitable edges. The best heuristics find the optimal solution on most of instances where it is available. 相似文献
25.
Øyvind Hauge Claudia Ayala Reidar Conradi 《Information and Software Technology》2010,52(11):1133-1154
ContextOpen source software (OSS) is changing the way organizations develop, acquire, use, and commercialize software.ObjectiveThis paper seeks to identify how organizations adopt OSS, classify the literature according to these ways of adopting OSS, and with a focus on software development evaluate the research on adoption of OSS in organizations.MethodBased on the systematic literature review method we reviewed publications from 24 journals and seven conference and workshop proceedings, published between 1998 and 2008. From a population of 24,289 papers, we identified 112 papers that provide empirical evidence on how organizations actually adopt OSS.ResultsWe show that adopting OSS involves more than simply using OSS products. We moreover provide a classification framework consisting of six distinctly different ways in which organizations adopt OSS. This framework is used to illustrate some of the opportunities and challenges organizations meet when approaching OSS, to show that OSS can be adopted successfully in different ways, and to organize and review existing research. We find that existing research on OSS adoption does not sufficiently describe the context of the organizations studied, and it fails to benefit fully from related research fields. While existing research covers a large number of topics, it contains very few closely related studies. To aid this situation, we offer directions for future research.ConclusionThe implications of our findings are twofold. On the one hand, practitioners should embrace the many opportunities OSS offers, but consciously evaluate the consequences of adopting it in their own context. They may use our framework and the success stories provided by the literature in their own evaluations. On the other hand, researchers should align their work, and perform more empirical research on topics that are important to organizations. Our framework may be used to position this research and to describe the context of the organization they are studying. 相似文献
26.
Claudia Archetti Luca Bertazzi Giuseppe Paletta M. Grazia Speranza 《Computers & Operations Research》2011
We consider a production-distribution system, where a facility produces one commodity which is distributed to a set of retailers by a fleet of vehicles. Each retailer defines a maximum level of the inventory. The production policy, the retailers replenishment policies and the transportation policy have to be determined so as to minimize the total system cost. The overall cost is composed by fixed and variable production costs at the facility, inventory costs at both facility and retailers and routing costs. We study two different types of replenishment policies. The well-known order-up to level (OU) policy, where the quantity shipped to each retailer is such that the level of its inventory reaches the maximum level, and the maximum level (ML) policy, where the quantity shipped to each retailer is such that the inventory is not greater than the maximum level. We first show that when the transportation is outsourced, the problem with OU policy is NP-hard, whereas there exists a class of instances where the problem with ML policy can be solved in polynomial time. We also show the worst-case performance of the OU policy with respect to the more flexible ML policy. Then, we focus on the ML policy and the design of a hybrid heuristic. We also present an exact algorithm for the solution of the problem with one vehicle. Results of computational experiments carried out on small size instances show that the heuristic can produce high quality solutions in a very short amount of time. Results obtained on a large set of randomly generated problem instances are also shown, aimed at comparing the two policies. 相似文献
27.
Alejandro Rago Claudia Marcos J. Andres Diaz-Pace 《Automated Software Engineering》2016,23(2):219-252
Textual requirements are very common in software projects. However, this format of requirements often keeps relevant concerns (e.g., performance, synchronization, data access, etc.) from the analyst’s view because their semantics are implicit in the text. Thus, analysts must carefully review requirements documents in order to identify key concerns and their effects. Concern mining tools based on NLP techniques can help in this activity. Nonetheless, existing tools cannot always detect all the crosscutting effects of a given concern on different requirements sections, as this detection requires a semantic analysis of the text. In this work, we describe an automated tool called REAssistant that supports the extraction of semantic information from textual use cases in order to reveal latent crosscutting concerns. To enable the analysis of use cases, we apply a tandem of advanced NLP techniques (e.g, dependency parsing, semantic role labeling, and domain actions) built on the UIMA framework, which generates different annotations for the use cases. Then, REAssistant allows analysts to query these annotations via concern-specific rules in order to identify all the effects of a given concern. The REAssistant tool has been evaluated with several case-studies, showing good results when compared to a manual identification of concerns and a third-party tool. In particular, the tool achieved a remarkable recall regarding the detection of crosscutting concern effects. 相似文献
28.
Claudia RusuAuthor Vitae Lorena AnghelAuthor Vitae 《Microprocessors and Microsystems》2011,35(7):613-631
Existing routing algorithms for 3D deal with regular mesh/torus 3D topologies. Today 3D NoCs are quite irregular, especially those with heterogeneous layers. In this paper, we present a routing algorithm targeting 3D networks-on-chip (NoCs) with incomplete sets of vertical links between adjacent layers. The routing algorithm tolerates multiple link and node failures, in the case of absence of NoC partitioning. In addition, it deals with congestion. The routing algorithm for 3D NoCs preserves the deadlock-free propriety of the chosen 2D routing algorithms. It is also scalable and supports a local reconfiguration that complements the reconfiguration of the 2D routing algorithms in case of failures of nodes or links. The algorithm incurs a small overhead in terms of exchanged messages for reconfiguration and does not introduce significant additional complexity in the routers. Theoretical analysis of the 3D routing algorithm is provided and validated by simulations for different traffic loads and failure rates. 相似文献
29.
Machine Translation of arbitrary input is difficult,but the output quality can be improved significantlyif writers create documents with MT in mind. Thisarticle deals with ``MTranslatability' – translatabilityof texts by MT systems. It identifies characteristics oftext that decrease MTranslatability and suggests waysto improve them. It also illustrates the effect of writingfor MTranslatability by showing before-and-after picturesof output from various commercially available MT systems,and gives an overview of tools that help identify and correctthe problems. 相似文献
30.