Magic structures of h-passivated 110 silicon nanowires

We report a genetic algorithm approach combined with ab initio calculations to determine the structure of hydrogenated 110 Si nanowires. As the number of atoms per length increases, we find that the cross section of the nanowire evolves from chains of six-atom rings to fused pairs of such chains to hexagons bounded by {001} and {111} facets. Our calculations predict that hexagonal wires become stable starting at about 1.2 nm diameter, which is consistent with recent experimental reports of nanowires with diameters of about 3 nm.     

Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for neurodegenerative diseases and cancer. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we herein describe the radiosynthesis of cis-[¹⁸F]1-(4-fluorobutyl-N-((1s,4s)-4-methylcyclohexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide ([¹⁸F]LU14) starting from the corresponding mesylate precursor. The first biological evaluation revealed that [¹⁸F]LU14 is a highly affine CB2R radioligand with >80% intact tracer in the brain at 30 min p.i. Its further evaluation by PET in a well-established rat model of CB2R overexpression demonstrated its ability to selectively image the CB2R in the brain and its potential as a tracer to further investigate disease-related changes in CB2R expression.     

Phosphate removal from synthetic and real wastewater using steel slags produced in Europe

Electric arc furnace steel slags (EAF-slags) and basic oxygen furnace steel slags (BOF-slags) were used to remove phosphate from synthetic solutions and real wastewater. The main objective of this study was to establish an overview of the phosphate removal capacities of steel slags produced in Europe. The influences of parameters, including pH, and initial phosphate and calcium concentrations, on phosphate removal were studied in a series of batch experiments. Phosphate removal mechanisms were also investigated via an in-depth study. The maximum capacities of phosphate removal from synthetic solutions ranged from 0.13 to 0.28 mg P/g using EAF-slags and from 1.14 to 2.49 mg P/g using BOF-slags. Phosphate removal occurred predominantly via the precipitation of Ca-phosphate complexes (most probably hydroxyapatite) according to two consecutive reactive phases: first, dissolution of CaO-slag produced an increase in Ca²⁺ and OH⁻ ion concentrations; then the Ca²⁺ and OH⁻ ions reacted with the phosphates to form hydroxyapatite. It was found that the release of Ca²⁺ from slag was not always enough to enable hydroxyapatite precipitation. However, our results indicated that the Ca²⁺ content of wastewater represented a further source of Ca²⁺ ions that were available for hydroxyapatite precipitation, thus leading to an increase in phosphate removal efficiencies.     

Proteomic Analysis Reveals Differential Expression Profiles in Idiopathic Pulmonary Fibrosis Cell Lines

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible lung disorder of unknown cause. This disease is characterized by profibrotic activation of resident pulmonary fibroblasts resulting in aberrant deposition of extracellular matrix (ECM) proteins. However, although much is known about the pathophysiology of IPF, the cellular and molecular processes that occur and allow aberrant fibroblast activation remain an unmet need. To explore the differentially expressed proteins (DEPs) associated with aberrant activation of these fibroblasts, we used the IPF lung fibroblast cell lines LL97A (IPF-1) and LL29 (IPF-2), compared to the normal lung fibroblast cell line CCD19Lu (NL-1). Protein samples were quantified and identified using a label-free quantitative proteomic analysis approach by liquid chromatography-tandem mass spectrometry (LC-MS/MS). DEPs were identified after pairwise comparison, including all experimental groups. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein–Protein Interaction (PPI) network construction were used to interpret the proteomic data. Eighty proteins expressed exclusively in the IPF-1 and IPF-2 clusters were identified. In addition, 19 proteins were identified up-regulated in IPF-1 and 10 in IPF-2; 10 proteins were down-regulated in IPF-1 and 2 in IPF-2 when compared to the NL-1 proteome. Using the search tool for retrieval of interacting genes/proteins (STRING) software, a PPI network was constructed between the DEPs and the 80 proteins expressed exclusively in the IPF-2 and IPF-1 clusters, containing 115 nodes and 136 edges. The 10 hub proteins present in the IPP network were identified using the CytoHubba plugin of the Cytoscape software. GO and KEGG pathway analyses showed that the hub proteins were mainly related to cell adhesion, integrin binding, and hematopoietic cell lineage. Our results provide relevant information on DEPs present in IPF lung fibroblast cell lines when compared to the normal lung fibroblast cell line that could play a key role during IPF pathogenesis.     

Insight into the structural,electrical and photoresponse properties of individual Fe:SrTiO3 nanotubes

Titanates are suitable for many applications such as oxygen sensing and tunable HTS (high temperature superconducting) microwave filters. The potential advantages of the nanostructured forms have been however scarcely explored compared to other oxides. In this work, the structural and electrical properties of individual iron-doped strontium titanate nanotubes (Fe:SrTiO₃) grown by electrophoretic deposition (EPD) were assessed for the first time, showing high stability and reproducibility. This result paves the way to further development of more complex titanate-based devices, as for instance nanostructured oxygen STFO sensors. From experimental data, it was concluded that the polycrystalline form of Fe:SrTiO₃ nanotubes is the major limitation to attain high photoconductivity gains when exposed to UV-light.     

Corrections to facilitate planar imaging of particle concentration in particle-laden flows using Mie scattering, part 1: collimated laser sheets

Planar nephelometry is a laser-based technique of imaging the light scattered from particles to provide information about the local number density of these particles. In many seeded flows of practical interest, such as pulverized coal flames, particle loadings are sufficiently high for the incident laser beam to be severely attenuated. Measurements in these flows are therefore difficult, and limited data are available under these conditions. Laser attenuation experiments were conducted in suspensions of spherical particles in water at various concentrations. This is used to formulate a calibration for the effects of diffuse scattering and laser sheet extinction. A model for the distribution of light through a heavily seeded, light-scattering medium is also developed and is compared with experimental results. It is demonstrated that the scattered signal may be considered proportional to the local particle concentration multiplied by the incident laser power. The incident laser power varies as a function of the attenuation by obscurement. This correction for planar nephelometry images thus extends the technique to provide pseudoquantitative data for instantaneous particle concentration measurements.     

Nematic-to-Isotropic Phase Transition in Poly(L-Lactide) with Addition of Cyclodextrin during Abiotic Degradation Study

Poly(L-lactide) is capable of self-assembly into a nematic mesophase under the influence of temperature and mechanical stresses. Therefore, subsequent poly(L-lactide) films were obtained and characterized, showing nematic liquid crystal properties both before and after degradation. Herein, we present that, by introducing β-cyclodextrin into the polymer matrix, it is possible to obtain a chiral nematic mesophase during pressing, regardless of temperature and time. The obtained poly(L-lactide) films exhibiting liquid crystal properties were subjected to degradation tests and the influence of degradation on these properties was determined. Thermotropic phase behavior was investigated using polarized optical microscopy, X-ray diffraction, and differential scanning calorimetry. The degradation process demonstrated an influence on the liquid crystal properties of pressed polymer films. The colored planar texture of the chiral nematic mesophase, which was not observed prior to degradation in films without the addition of β-cyclodextrin, appeared after incubation in water as a result of the entrapment of degradation products in the polymer matrix. These unusual tailor-made properties, obtained in liquid crystals in (bio)degradable polymers using a simple method, demonstrate the potential for advanced photonic applications.     

Inclusion Body Myositis and Neoplasia: A Narrative Review

Inclusion body myositis (IBM) is an acquired, late-onset inflammatory myopathy, with both inflammatory and degenerative pathogenesis. Although idiopathic inflammatory myopathies may be associated with malignancies, IBM is generally not considered paraneoplastic. Many studies of malignancy in inflammatory myopathies did not include IBM patients. Indeed, IBM is often diagnosed only after around 5 years from onset, while paraneoplastic myositis is generally defined as the co-occurrence of malignancy and myopathy within 1 to 3 years of each other. Nevertheless, a significant association with large granular lymphocyte leukemia has been recently described in IBM, and there are reports of cancer-associated IBM. We review the pathogenic mechanisms supposed to be involved in IBM and outline the common mechanisms in IBM and malignancy, as well as the therapeutic perspectives. The terminally differentiated, CD8+ highly cytotoxic T cells expressing NK features are central in the pathogenesis of IBM and, paradoxically, play a role in some cancers as well. Interferon gamma plays a central role, mostly during the early stages of the disease. The secondary mitochondrial dysfunction, the autophagy and cell cycle dysregulation, and the crosstalk between metabolic and mitogenic pathways could be shared by IBM and cancer. There are intermingled subcellular mechanisms in IBM and neoplasia, and probably their co-existence is underestimated. The link between IBM and cancers deserves further interest, in order to search for efficient therapies in IBM and to improve muscle function, life quality, and survival in both diseases.     

Fail-Awareness: An Approach to Construct Fail-Safe Systems

We present a framework for building fail-safe hard real-time applications in timed asynchronous distributed systems subject to communication partitions and performance, omission, and crash failures. Most distributed systems built from commercial-off-the-shelf (COTS) processor and communication services are subject to such partitions because their COTS components do not provide hard real-time guarantees. Also custom designed systems can be subject to partitions due to unmaskable link or router failures. The basic assumption behind our approach is that each processor has a local hardware clock that proceeds within a linear envelope of real-time. This allows one to compute an upper bound on the actual delays incurred by a particular processing sequence or message transmission. Services and applications can use these computed bounds to detect when they cannot guarantee all their standard properties because of excessive delays. This allows an application to be fail-aware, that is, to detect when it cannot guarantee all its safety properties and in particular, to detect when to switch to a fail-safe mode.     

Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential

Diffuse large B cell lymphoma (DLBCL) is an aggressive B cell lymphoma characterized by a heterogeneous behavior and in need of more accurate biological characterization monitoring and prognostic tools. Extracellular vesicles are secreted by all cell types and are currently established to some extent as representatives of the cell of origin. The present study characterized and evaluated the diagnostic and prognostic potential of plasma extracellular vesicles (EVs) proteome in DLBCL by using state-of-the-art mass spectrometry. The EV proteome is strongly affected by DLBCL status, with multiple proteins uniquely identified in the plasma of DLBCL. A proof-of-concept classifier resulted in highly accurate classification with a sensitivity and specificity of 1 when tested on the holdout test data set. On the other hand, no proteins were identified to correlate with non-germinal center B-cell like (non-GCB) or GCB subtypes to a significant degree after correction for multiple testing. However, functional analysis suggested that antigen binding is regulated when comparing non-GCB and GCB. Survival analysis based on protein quantitative values and clinical parameters identified multiple EV proteins as significantly correlated to survival. In conclusion, the plasma extracellular vesicle proteome identifies DLBCL cancer patients from healthy donors and contains potential EV protein markers for prediction of survival.