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21.
Renato Bacchetta Paolo Tremolada Cristiano Di Benedetto Nadia Santo Umberto Fascio Giuseppe Chirico Anita Colombo Marina Camatini Paride Mantecca 《Carbon》2012,50(12):4607-4618
Lethal and teratogenic potentials of carbon nanoparticles (CNPs) in their amorphous form were investigated by the standardized Frog Embryo Teratogenesis Assay-Xenopus (FETAX), a 96-h in vitro whole-embryo toxicity test based on the amphibian Xenopus laevis. Embryos were acutely exposed to 1, 10, 100 and 500 mg/L CNP suspensions and evaluated for lethality, malformations and growth inhibition. Larvae were processed for histological and ultrastructural analyses to detect the main affected organs, to look for specific lesions at the subcellular level and to image and track CNPs into tissues. Only the highest CNP suspension resulted in being embryolethal for X. laevis larvae, while malformed larva percentages significantly differed from controls starting from 100 mg/L. The stomach and gut were the preferential CNP accumulation sites, on the contrary, the digestive epithelium remained intact. The analyses showed the presence of isolated nanoparticles and/or aggregates in different secondary target organs. CNPs were found in circulating erythrocytes. The research confirms the good tolerance of X. laevis towards pure elemental carbon in its nanoparticulate amorphous form, but highlights the possibility of CNP transfer toward all body areas. 相似文献
22.
Sorption of propylene and propane in polyurethane membranes containing silver nanoparticles
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Carolina Guedes Fioravante Rezende Cristiano Piacsek Borges Alberto Claudio Habert 《应用聚合物科学杂志》2016,133(4)
The preparation of a facilitated transport membrane of polyurethane (PU) containing silver nanoparticles is reported. The propylene and propane sorption was investigated aiming at the selective separation from C3s mixtures. The silver particles were photogenerated in situ into the polyurethane matrix using UV light radiation and silver triflate (AgCF3SO3) as precursor. The morphological properties of these membranes (PUAg) reveled great dispersion of silver particles, which size was smaller than 110 nm. The propylene solubility in PUAg resulted more than four times superior to the one for the pure PU membrane, revealing the high affinity between silver and propylene. Flory–Huggins theory was more accurate to describe the propylene sorption behavior in PUAg than Henry's model. The ideal solubility selectivity of PUAg membrane resulted 24.4, indicating that there is a good potential for an industrial application aiming at the separation of propylene/propane. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 42916. 相似文献
23.
Dr. Nicola d'Avanzo Dr. Maria Chiara Cristiano Prof. Luisa Di Marzio Maria Chiara Bruno Prof. Donatella Paolino Prof. Christian Celia Prof. Massimo Fresta 《ChemMedChem》2022,17(9):e202200067
The use of proper nanocarriers for dermal and transdermal delivery of anti-inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate-based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co-loaded aspasomes for the development of an effective anti-inflammatory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co-loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn® gel, with a rapid decrease of chemical-induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti-inflammatory therapy. 相似文献
24.
Jose Daniel B. de Mello Karyne C. Juste Philippe Kapsa Cristiano Binder Aloisio N. Klein 《摩擦学汇刊》2018,61(3):560-568
Recently, we presented the tribological evaluation of self-lubricating sintered steels produced by taking advantage of the powder injection molding process, the recently introduced plasma-assisted debinding and sintering process, and the in situ formation of solid lubricant particles. This new processing route promotes the in situ generation of nanostructured turbostratic graphite particles during silicon carbide dissociation. In this work, we present the influence of surface finishing on the tribological behavior of self-lubricating composites sintered at 1150°C with (3 and 5 wt%) and without SiC additions. We discuss the effects of the surface topography (Ra) on the friction coefficient and wear rates of specimens and counterbodies. The tribological behavior was analyzed using linear reciprocating sliding tests (constant load of 7 N, 60-min duration). It was shown that the reduction in surface roughness increased both the friction coefficients and wear rates of specimens and counterbodies, probably due to plastic deformation and consequent graphite reservoir sealing. Chemical analyses of the wear scars using scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis showed a tribolayer that was composed predominantly of carbon and oxygen. Analyses of the wear scars showed traces of plastic deformation on both samples and counterbodies and the predominance of abrasion as the main wear mechanism. 相似文献
25.
Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3–36)
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Dr. Kelly E. Henry Dr. Deborah J. Kerwood Dr. Damian G. Allis Jayme L. Workinger Ron L. Bonaccorso Prof. George G. Holz Prof. Christian L. Roth Prof. Jon Zubieta Prof. Robert P. Doyle 《ChemMedChem》2016,11(9):1015-1021
Vitamin B12–peptide conjugates have considerable therapeutic potential through improved pharmacokinetic and/or pharmacodynamic properties imparted on the peptide upon covalent attachment to vitamin B12 (B12). There remains a lack of structural studies investigating the effects of B12 conjugation on peptide secondary structure. Determining the solution structure of a B12–peptide conjugate or conjugates and measuring functions of the conjugate(s) at the target peptide receptor may offer considerable insight concerning the future design of fully optimized conjugates. This methodology is especially useful in tandem with constrained molecular dynamics (MD) studies, such that predictions may be made about conjugates not yet synthesized. Focusing on two B12 conjugates of the anorectic peptide PYY(3–36), one of which was previously demonstrated to have improved food intake reduction compared with PYY(3–36), we performed NMR structural analyses and used the information to conduct MD simulations. The study provides rare structural insight into vitamin B12 conjugates and validates the fact that B12 can be conjugated to a peptide without markedly affecting peptide secondary structure. 相似文献
26.
27.
Zusammenfassung Faserige Holozellulose aus Rotbuchenholz liefert Blattgefüge von derart beachtlichen Festigkeitseigenschaften (Rei?l?nge bis
zu 8500, Falzzahl bis etwa 1100, Berstfestigkeit bis 4,8 kg/cm2), da? ihre Verwendbarkeit in der Papierherstellung als gesichert angesehen werden kann.
Die nicht mehr als 2,1 % Lignin enthaltende Holozellulosefaser ist vorl?ufig in einer Ausbeute von 67 bis 79 %, auf Buchenholzgewicht
gerechnet, erh?ltlich, so da? sich bei einer wirtschaftlichen Darstellungsweise eine Erh?hung der Ausbeute von 60 bis 100
% gegenüber der seither in der Technik erreichten erzielen lassen dürfte.
Die Untersuchung wird in verschiedenen, an betreffender Stelle n?her gekennzeichneten Richtungen fortgesetzt, wobei die Gestaltung
der Herstellungsweise zu einer wirtschaftlich durchführbaren als vordringliche Aufgabe angesehen wird.
Mitteilung aus der Holzforschungsstelle im Institut für Zellulosechemie der Technischen Hochschule Darmstadt.
Die Untersuchung wurde mit Mitteln ausgeführt, die auf Veranlassung von Herrn Landesforstmeister Staatsrat Dr. h. c. Hesse
vom Herrn Reichsforstmeister zur Verfügung gestellt waren; beiden gebührt unser verbindlichster Dank. 相似文献
28.
Maurício L. Sforça Inez V. P. Yoshida Cristiano P. Borges Suzana P. Nunes 《应用聚合物科学杂志》2001,82(1):178-185
Hybrid materials were prepared incorporating silica networks by the sol–gel process into the poly(amide-b-polyether) block copolymer PEBAX®. PEBAX®/silica hybrids were characterized by transmission electron microscopy, atomic force microscopy, differential scanning calorimetry, and X-ray diffraction. The pervaporation of phenol from dilute aqueous solutions through hybrid membranes was investigated. Films prepared with lower silica contents showed better dispersed inorganic networks and were more selective in the pervaporation of phenol/water solutions. Films prepared with higher silica contents had a clear phase-separated morphology with lower performance in pervaporation. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 178–185, 2001 相似文献
29.
30.
In [V.I. Voloshin, On the upper chromatic number of a hypergraph, Australas. J. Combin. 11 (1995) 25-45], Voloshin proposed the following generalization of the Helly property. Let p?1, q?0 and s?0. A hypergraph H is (p,q)-intersecting when every partial hypergraph H′⊆H formed by p or less hyperedges has intersection of cardinality at least q. A hypergraph H is (p,q,s)-Helly when every partial (p,q)-intersecting hypergraph H′⊆H has intersection of cardinality at least s. In this work, we study the complexity of determining whether H is (p,q,s)-Helly. 相似文献