全文获取类型
收费全文 | 3392篇 |
免费 | 237篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 18篇 |
综合类 | 2篇 |
化学工业 | 1245篇 |
金属工艺 | 36篇 |
机械仪表 | 89篇 |
建筑科学 | 108篇 |
矿业工程 | 1篇 |
能源动力 | 84篇 |
轻工业 | 1006篇 |
水利工程 | 15篇 |
石油天然气 | 16篇 |
无线电 | 122篇 |
一般工业技术 | 407篇 |
冶金工业 | 127篇 |
原子能技术 | 4篇 |
自动化技术 | 352篇 |
出版年
2024年 | 10篇 |
2023年 | 51篇 |
2022年 | 237篇 |
2021年 | 259篇 |
2020年 | 123篇 |
2019年 | 125篇 |
2018年 | 142篇 |
2017年 | 151篇 |
2016年 | 136篇 |
2015年 | 110篇 |
2014年 | 185篇 |
2013年 | 270篇 |
2012年 | 253篇 |
2011年 | 246篇 |
2010年 | 165篇 |
2009年 | 181篇 |
2008年 | 170篇 |
2007年 | 161篇 |
2006年 | 101篇 |
2005年 | 95篇 |
2004年 | 72篇 |
2003年 | 63篇 |
2002年 | 47篇 |
2001年 | 28篇 |
2000年 | 33篇 |
1999年 | 26篇 |
1998年 | 41篇 |
1997年 | 41篇 |
1996年 | 27篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 1篇 |
1989年 | 6篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有3632条查询结果,搜索用时 15 毫秒
41.
Cristina Pignotti 《Systems & Control Letters》2012,61(1):92-97
In this paper, we consider the wave equation with internal distributed time delay and local damping in a bounded and smooth domain Ω⊂Rn. When the local damping acts on a neighborhood of a suitable part of the boundary of Ω, we show that an exponential stability result holds if the coefficient of the delay term is sufficiently small. 相似文献
42.
Lorella Fatone Marco Giacinti Francesca Mariani Maria Cristina Recchioni Francesco Zirilli 《The Journal of supercomputing》2012,62(3):1480-1501
This paper shows two examples of how the analysis of option pricing problems can lead to computational methods efficiently implemented in parallel. These computational methods outperform ??general purpose?? methods (i.e., for example, Monte Carlo, finite differences methods). The GPU implementation of two numerical algorithms to price two specific derivatives (continuous barrier options and realized variance options) is presented. These algorithms are implemented in CUDA subroutines ready to run on Graphics Processing Units (GPUs) and their performance is studied. The realization of these subroutines is motivated by the extensive use of the derivatives considered in the financial markets to hedge or to take risk and by the interest of financial institutions in the use of state of the art hardware and software to speed up the decision process. The performance of these algorithms is measured using the (CPU/GPU) speed up factor, that is using the ratio between the (wall clock) times required to execute the code on a CPU and on a GPU. The choice of the reference CPU and GPU used to evaluate the speed up factors presented is stated. The outstanding performance of the algorithms developed is due to the mathematical properties of the pricing formulae used and to the ad hoc software implementation. In the case of realized variance options when the computation is done in single precision the comparisons between CPU and GPU execution times gives speed up factors of the order of a few hundreds. For barrier options, the corresponding speed up factors are of about fifteen, twenty. The CUDA subroutines to price barrier options and realized variance options can be downloaded from the website http://www.econ.univpm.it/recchioni/finance/w13. A?more general reference to the work in mathematical finance of some of the authors and of their coauthors is the website http://www.econ.univpm.it/recchioni/finance/. 相似文献
43.
A survey of QoS architectures 总被引:14,自引:0,他引:14
Over the past several years there has been a considerable amount of research within the field of quality-of-service (QoS)
support for distributed multimedia systems. To date, most of the work has been within the context of individual architectural
layers such as the distributed system platform, operating system, transport subsystem and network layers. Much less progress
has been made in addressing the issue of overall end-to-end support for multimedia communications. In recognition of this,
a number of research teams have proposed the development of QoS architectures which incorporate QoS-configurable interfaces
and QoS driven control and management mechanisms across all architectural layers. This paper examines the state-of-the-art
in the development of QoS architectures. The approach taken is to present QoS terminology and a generalized QoS framework
for understanding and discussing QoS in the context of distributed multimedia systems. Following this, we evaluate a number
of QoS architectures that have emerged in the literature. 相似文献
44.
A Peer-to-Peer Approach to Web Service Discovery 总被引:9,自引:0,他引:9
Web Services are emerging as a dominant paradigm for constructing and composing distributed business applications and enabling enterprise-wide interoperability. A critical factor to the overall utility of Web Services is a scalable, flexible and robust discovery mechanism. This paper presents a Peer-to-Peer (P2P) indexing system and associated P2P storage that supports large-scale, decentralized, real-time search capabilities. The presented system supports complex queries containing partial keywords and wildcards. Furthermore, it guarantees that all existing data elements matching a query will be found with bounded costs in terms of number of messages and number of nodes involved. The key innovation is a dimension reducing indexing scheme that effectively maps the multidimensional information space to physical peers. The design and an experimental evaluation of the system are presented. 相似文献
45.
Freitas SP Gonçalves TC Serrão JE Santos-Mallet JR 《Microscopy research and technique》2007,70(4):355-360
Male of Triatoma rubrofasciata has four elongated sac-like reproductive mesodermic accessory glands, lined by an inner single layer of secretory cells, with basal plasma membrane infolds and short apical microvilli, and externally enveloped by a thin visceral muscle layer. The secretory cells have a well-developed rough endoplasmic reticulum, Golgi complex, mitochondria, and secretory granules. In one day old adult the gland cells are poorly developed, presenting small, electron-transparent secretory granules scattered among the rough endoplasmatic reticulum, whereas in three days old adult these cells have the cisternae of the rough endoplasmatic reticulum varing size degree, filled with granular electrondense content. In five days old males the secretory granules increase in diameter, being released to the gland lumen. Therefore, there is an increase of the secretory activity according to male maturation. 相似文献
46.
Veronica Dimuccio Linda Bellucci Marianna Genta Cristina Grange Maria Felice Brizzi Maddalena Gili Sara Gallo Maria Laura Centomo Federica Collino Benedetta Bussolati 《International journal of molecular sciences》2022,23(20)
Simple SummaryDiabetic nephropathy is one of the most frequent complications of diabetes, resulting from diffuse damage to different kidney cells. The identification of subjects at risk is mandatory to prevent its development and provide appropriate therapies reducing the unmanageable evolution towards end-stage kidney disease. The aim of this work was to identify urinary-derived extracellular vesicles (EVs) miRNA cargo to be used as biomarker of kidney damage in diabetic patients. The miRNA profile was then correlated with the molecular mechanism associated with the glomerular and tubular damage using a diabetic-like model. In patients, miR145 and miR126 in urinary EVs increased together with albuminuria. MiR145 and miR126 increased in parallel in EVs from renal epithelial cells undergoing transition to a fibrotic mesenchymal phenotype. These data unveiled a role for miR126 and miR145 as the biomarkers of damage progression and proteinuria development in diabetic nephropathy. AbstractDiabetic nephropathy (DN) is a severe kidney-related complication of type 1 and type 2 diabetes and the most frequent cause of end-stage kidney disease. Extracellular vesicles (EVs) present in the urine mainly derive from the cells of the nephron, thus representing an interesting tool mirroring the kidney’s physiological state. In search of the biomarkers of disease progression, we here assessed a panel of urinary EV miRNAs previously related to DN in type 2 diabetic patients stratified based on proteinuria levels. We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. In vitro, miRNA modulation was assessed in a model of TGF-β1-induced glomerular damage within a three-dimensional perfusion system, as well as in a model of tubular damage induced by albumin and glucose overload. Both renal tubular cells and podocytes undergoing epithelial to mesenchymal transition released EVs containing increased miR145 and miR126 levels. At the same time, miR126 levels were reduced in EVs released by glomerular endothelial cells. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition. 相似文献
47.
Ana Sofia Ferreira Ana Margarida Silva Diana Pinto Manuela M. Moreira Ricardo Ferraz Jaroslava varc-Gaji Paulo C. Costa Cristina Delerue-Matos Francisca Rodrigues 《International journal of molecular sciences》2022,23(23)
Oral mucositis (OM), a common side effect of oncological treatment, is an oral mucosal disorder characterized by painful ulcerations and increased risk of infection. The use of natural antioxidants to suppress the redox imbalance responsible for the OM condition has emerged as an interesting approach to prevent/treat OM. This study aims to explore the chestnut (Castana sativa) shells as potential active ingredient against OM. Therefore, chestnut shells were extracted at different temperatures (110–180 °C) by Subcritical Water Extraction (SWE), aiming to recover antioxidants. The extracts were also evaluated against microorganisms present in the oral cavity as well as on human oral cell lines (TR146 and HSC3). The highest phenolic content was obtained with the extraction temperature of 110 °C, exhibiting the best antioxidant/antiradical activities and scavenging efficiencies against HOCl (IC50 = 4.47 μg/mL) and ROO• (0.73 μmol TE/mg DW). High concentrations of phenolic acids (e.g., gallic and protocatechuic acids) and flavanoids (catechin, epicatechin and rutin) characterized the phenolic profile. The antimicrobial activity against several oral microorganisms present in the oral cavity during OM, such as Streptococcus, Staphylococcus, Enterococcus, and Escherichia, was demonstrated. Finally, the effects on HSC3 and TR146 cell lines revealed that the extract prepared at 110 °C had the lowest IC50 (1325.03 and 468.15 µg/mL, respectively). This study highlights the potential effects of chestnut shells on OM. 相似文献
48.
Chiara Bellomo Cristina Pavan Gianluca Fiore Guillermo Escolano-Casado Lorenzo Mino Francesco Turci 《International journal of molecular sciences》2022,23(23)
Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the overall toxicity of quartz is still largely unexplored, primarily because of the strong electrostatic adhesion forces that prevent isolation of the nanofraction. Furthermore, fractured silica dust exhibits special surface features, namely nearly free silanols (NFS), which impart a membranolytic activity to quartz. Nanoquartz can be synthetized via bottom-up methods, but the surface chemistry of such crystals strongly differs from that of nanoparticles resulting from fracturing. Here, we report a top-down milling procedure to obtain a nanometric quartz that shares the key surface properties relevant to toxicity with fractured quartz. The ball milling was optimized by coupling the dry and wet milling steps, using water as a dispersing agent, and varying the milling times and rotational speeds. Nanoquartz with a strong tendency to form submicrometric agglomerates was obtained. The deagglomeration with surfactants or simulated body fluids was negligible. Partial lattice amorphization and a bimodal crystallite domain size were observed. A moderate membranolytic activity, which correlated with the number of NFS, signaled coherence with the previous toxicological data. A membranolytic nanoquartz for toxicological investigations was obtained. 相似文献
49.
Diana Loureno Raquel Lopes Carolina Pestana Ana C. Queirs Cristina Joo Emilie Arnault Carneiro 《International journal of molecular sciences》2022,23(21)
Despite the wide variety of existing therapies, multiple myeloma (MM) remains a disease with dismal prognosis. Choosing the right treatment for each patient remains one of the major challenges. A new approach being explored is the use of ex vivo models for personalized medicine. Two-dimensional culture or animal models often fail to predict clinical outcomes. Three-dimensional ex vivo models using patients’ bone marrow (BM) cells may better reproduce the complexity and heterogeneity of the BM microenvironment. Here, we review the strengths and limitations of currently existing patient-derived ex vivo three-dimensional MM models. We analyze their biochemical and biophysical properties, molecular and cellular characteristics, as well as their potential for drug testing and identification of disease biomarkers. Furthermore, we discuss the remaining challenges and give some insight on how to achieve a more biomimetic and accurate MM BM model. Overall, there is still a need for standardized culture methods and refined readout techniques. Including both myeloma and other cells of the BM microenvironment in a simple and reproducible three-dimensional scaffold is the key to faithfully mapping and examining the relationship between these players in MM. This will allow a patient-personalized profile, providing a powerful tool for clinical and research applications. 相似文献
50.
Cosmin Vasilica Pricope Bogdan Ionel Tamba Gabriela Dumitrita Stanciu Magdalena Cuciureanu Anca Narcisa Neagu Ioana Creanga-Murariu Bogdan-Ionut Dobrovat Cristina Mariana Uritu Silviu Iulian Filipiuc Bianca-Mariana Pricope Teodora Alexa-Stratulat 《International journal of molecular sciences》2022,23(21)
Chronic neuropathic pain (CNP) affects around 10% of the general population and has a significant social, emotional, and economic impact. Current diagnosis techniques rely mainly on patient-reported outcomes and symptoms, which leads to significant diagnostic heterogeneity and subsequent challenges in management and assessment of outcomes. As such, it is necessary to review the approach to a pathology that occurs so frequently, with such burdensome and complex implications. Recent research has shown that imaging methods can detect subtle neuroplastic changes in the central and peripheral nervous system, which can be correlated with neuropathic symptoms and may serve as potential markers. The aim of this paper is to review available imaging methods used for diagnosing and assessing therapeutic efficacy in CNP for both the preclinical and clinical setting. Of course, further research is required to standardize and improve detection accuracy, but available data indicate that imaging is a valuable tool that can impact the management of CNP. 相似文献