全文获取类型
收费全文 | 3229篇 |
免费 | 282篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 18篇 |
综合类 | 2篇 |
化学工业 | 1232篇 |
金属工艺 | 30篇 |
机械仪表 | 85篇 |
建筑科学 | 108篇 |
矿业工程 | 1篇 |
能源动力 | 83篇 |
轻工业 | 998篇 |
水利工程 | 14篇 |
石油天然气 | 16篇 |
无线电 | 98篇 |
一般工业技术 | 402篇 |
冶金工业 | 79篇 |
原子能技术 | 4篇 |
自动化技术 | 344篇 |
出版年
2024年 | 10篇 |
2023年 | 49篇 |
2022年 | 238篇 |
2021年 | 258篇 |
2020年 | 123篇 |
2019年 | 122篇 |
2018年 | 141篇 |
2017年 | 147篇 |
2016年 | 137篇 |
2015年 | 113篇 |
2014年 | 178篇 |
2013年 | 271篇 |
2012年 | 252篇 |
2011年 | 244篇 |
2010年 | 159篇 |
2009年 | 172篇 |
2008年 | 163篇 |
2007年 | 161篇 |
2006年 | 94篇 |
2005年 | 93篇 |
2004年 | 71篇 |
2003年 | 60篇 |
2002年 | 43篇 |
2001年 | 28篇 |
2000年 | 29篇 |
1999年 | 20篇 |
1998年 | 23篇 |
1997年 | 24篇 |
1996年 | 25篇 |
1995年 | 12篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 1篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1985年 | 3篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有3514条查询结果,搜索用时 15 毫秒
51.
Computer simulations of signal transduction mechanism in {alpha}1B-adrenergic and m3-muscarinic receptors 总被引:2,自引:0,他引:2
Fanelli Franceses; Menziani M.Cristina; de Benedetti Pier G. 《Protein engineering, design & selection : PEDS》1995,8(6):557-564
Molecular dynamices simulations of the hamster 1Badrenergicand the rat m3-muscarinic seven-helix bundle receptor modelshave been carried out. The free, agonist-bound and antagonist-boundforms have been considered. Moreover, three mutant forms ofthe m3-muscarinic recep-tor (N507A, N507D and N507S) have alsobeen simulated; among these, the N507S mutant shows a constitutiveactivity. A comparative structural/dynamics analysis has beenperformed to elucidate (i) the perturbations induced by thefunctionally different ligands upon binding to their targetreceptor, (ii) the features of the three single-point mutantswith respect to the receptor wild type and (iii) the propertiesshared by the agonist-boundforms of the 1B-adrenergic receptorand the m3-muscarinic receptor and by the constitutively activemutant N507S. The consistency obtained between the structuralrearrangement of the transmembrane seven-helix bundle modelsconsidered, and the experimental pharmacological efficaciesof the ligands and of the mutants, constitute an important validationof the 3-D models obtained and allow the inference of the mechanismof ligand- or mutation-induced receptor activation at the molecularlevel. 相似文献
52.
Patricia Bondia Rocío Jurado Santiago Casado José M. Domínguez‐Vera Natividad Gálvez Cristina Flors 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(17)
The combination of complementary techniques to characterize materials at the nanoscale is crucial to gain a more complete picture of their structure, a key step to design and fabricate new materials with improved properties and diverse functions. Here it is shown that correlative atomic force microscopy (AFM) and localization‐based super‐resolution microscopy is a useful tool that provides insight into the structure and emissive properties of fluorescent β‐lactoglobulin (βLG) amyloid‐like fibrils. These hybrid materials are made by functionalization of βLG with organic fluorophores and quantum dots, the latter being relevant for the production of 1D inorganic nanostructures templated by self‐assembling peptides. Simultaneous functionalization of βLG fibers by QD655 and QD525 allows for correlative AFM and two‐color super‐resolution fluorescence imaging of these hybrid materials. These experiments allow the combination of information about the topography and number of filaments that compose a fibril, as well as the emissive properties and nanoscale spatial distribution of the attached fluorophores. This study represents an important step forward in the characterization of multifunctionalized hybrid materials, a key challenge in nanoscience. 相似文献
53.
54.
55.
56.
Amir Yair Danilov Claudiu Dolev Danny Kirsch Jonathan Lane John Nita-Rotaru Cristina Olsen Josh Zage David 《Dependable and Secure Computing, IEEE Transactions on》2010,7(1):80-93
This paper presents the first hierarchical Byzantine fault-tolerant replication architecture suitable to systems that span multiple wide-area sites. The architecture confines the effects of any malicious replica to its local site, reduces message complexity of wide-area communication, and allows read-only queries to be performed locally within a site for the price of additional standard hardware. We present proofs that our algorithm provides safety and liveness properties. A prototype implementation is evaluated over several network topologies and is compared with a flat Byzantine fault-tolerant approach. The experimental results show considerable improvement over flat Byzantine replication algorithms, bringing the performance of Byzantine replication closer to existing benign fault-tolerant replication techniques over wide area networks. 相似文献
57.
Cristina Teixeira José Covas Thomas Stützle A. Gaspar‐Cunha 《International Transactions in Operational Research》2011,18(2):271-291
The twin‐screw configuration problem arises during polymer extrusion and compounding. It consists in defining the location of a set of pre‐defined screw elements along the screw axis in order to optimize different, typically conflicting objectives. In this paper, we present a simple yet effective stochastic local search (SLS) algorithm for this problem. Our algorithm is based on efficient single‐objective iterative improvement algorithms, which have been developed by studying different neighborhood structures, neighborhood search strategies, and neighborhood restrictions. These algorithms are embedded into a variation of the two‐phase local search framework to tackle various bi‐objective versions of this problem. An experimental comparison with a previously proposed multi‐objective evolutionary algorithm shows that a main advantage of our SLS algorithm is that it converges faster to a high‐quality approximation to the Pareto front. 相似文献
58.
Caio César Mori Carélo Ives Renê Venturini Pola Ricardo Rodrigues Ciferri Agma Juci Machado Traina Caetano Traina Jr Cristina Dutra de Aguiar Ciferri 《Information Systems》2011
Searching in a dataset for elements that are similar to a given query element is a core problem in applications that manage complex data, and has been aided by metric access methods (MAMs). A growing number of applications require indices that must be built faster and repeatedly, also providing faster response for similarity queries. The increase in the main memory capacity and its lowering costs also motivate using memory-based MAMs. In this paper, we propose the Onion-tree, a new and robust dynamic memory-based MAM that slices the metric space into disjoint subspaces to provide quick indexing of complex data. It introduces three major characteristics: (i) a partitioning method that controls the number of disjoint subspaces generated at each node; (ii) a replacement technique that can change the leaf node pivots in insertion operations; and (iii) range and k-NN extended query algorithms to support the new partitioning method, including a new visit order of the subspaces in k-NN queries. Performance tests with both real-world and synthetic datasets showed that the Onion-tree is very compact. Comparisons of the Onion-tree with the MM-tree and a memory-based version of the Slim-tree showed that the Onion-tree was always faster to build the index. The experiments also showed that the Onion-tree significantly improved range and k-NN query processing performance and was the most efficient MAM, followed by the MM-tree, which in turn outperformed the Slim-tree in almost all the tests. 相似文献
59.
Adriana S. Vivacqua Ana Cristina B. Garcia Angela Gomes 《Expert systems with applications》2011,38(2):1139-1147
Facilitating meetings is not an easy task. To assist the facilitator, we have been designing intelligent support systems, which can help contextual sensemaking, decision making and action. However, these systems are constructed based on behavioral models that provide guidelines to understand participant behaviors. This paper presents an ontology to describe participants’ behaviors in collaborative design meetings and rules that correlate them with the group’s acceptance of the final product. This ontology describes the group dynamics at collocated meetings, using verbal and non-verbal cues of attention shifts and attention maintenance as its basic constructs. The objective of creating this ontology was to better understand face-to-face meetings to eventually help meeting facilitators identify issues that may lead to dissatisfaction with the final product through behavioral cues. The ontology was derived through extensive analysis of a series of engineering design session videos. The design group was composed of experts with similar backgrounds, but working in different divisions of the same company. Different points of view were argued and decisions were made at the end of each meeting. After each meeting, participants were asked to asynchronously commit to the decisions made in the group. Our ontology can be used to identify the factors that lead to an undesired outcome, and now serves as a basis for a new project, which uses rules to support design meetings, improve final artifact acceptance and reduce rework. Our conclusions point out correlations between designers’ behaviors and future artifact acceptance and actions that interrupt or bring back group attention. The ontology was validated through application to other meeting situations. These findings may guide software developers in the creation of tools to support group design, and may be applied by an intelligent system. 相似文献
60.
Otávio Augusto Lazzarini Lemos Sushil Bajracharya Cristina Lopes 《Information and Software Technology》2011,53(4):294-306