A Simon Effect in Pigeons.

Pigeons pecked left versus right keys contingent upon the color presented at 1 of those locations. Spatial-response latencies were shorter when the color appeared at the same location as the required response than at the opposite location. This Simon effect occurred when the stimulus on the alternative key was constant, varied from trial to trial, or changed when the color cue appeared and when the reinforcement probability for correct responses was the same on corresponding as on noncorresponding trials. Humans performing the same task by touching the keys also showed the Simon effect. These findings demonstrate that for pigeons, too, a relevant symbolic cue activates a spatial code that produces faster responses at the location corresponding with the activated code. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Determinants of right–left and top–bottom prevalence for two-dimensional spatial compatibility.

When stimulus and response sets vary along horizontal and vertical dimensions, the horizontal dimension is more dominant than the vertical one, an effect called right–left prevalence. Three accounts have been proposed that attribute the effect to a reduced ability to code vertical locations when horizontal codes are also present, the use of right–left effectors, or a difference in salience of the 2 dimensions. The accounts differ in terms of whether the ability to code and process the 2 dimensions is of limited capacity and whether the prevalence effect is a consequence of the effectors used for responding. The authors report 4 experiments that evaluated these issues. Results indicate that use of right–left effectors is important to the right–left prevalence effect because it increases the salience of the horizontal dimension. However, a top–bottom prevalence effect can be obtained if the vertical dimension is made more salient. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

压缩系统对温度突升响应的动态分析

基于时间滞后概念,建立了压缩系统动态响应分析的通用模型,并对温度突升条件下多级轴流压缩系统的动态响应及气动稳定性进行了详细的数值分析。对两个算例的分析,结果表明了本文新模型的可行性。     

Efficient and accurate multilayer solid‐shell element: non‐linear materials at finite strain

We present in this paper an efficient and accurate low‐order solid‐shell element formulation for analyses of large deformable multilayer shell structures with non‐linear materials. The element has only displacement degrees of freedom (dofs), and an optimal number of enhancing assumed strain (EAS) parameters to pass the patch tests (both membrane and out‐of‐plane bending) and to remedy volumetric locking. Based on the mixed Fraeijs de Veubeke‐Hu‐Washizu (FHW) variational principle, the in‐plane and out‐of‐plane bending behaviours are improved and the locking associated with (nearly) incompressible materials is avoided via a new efficient enhancement of strain tensor. Shear locking and curvature thickness locking are resolved effectively by using the assumed natural strain (ANS) method. Two non‐linear 3‐D constitutive models (Mooney–Rivlin material and hyperelastoplastic material at finite strain) are applied directly without requiring the enforcement of the plane‐stress assumption. In particular, we give a simple derivation for the hyperelastoplastic model using spectral representations. In addition, the present element has a well‐defined lumped mass matrix, and provides double‐side contact surfaces for shell contact problems. With the dynamics referred to a fixed inertial frame, the present element can be used to analyse multilayer shell structures undergoing large overall motion. Numerical examples involving static analyses and implicit/explicit dynamic analyses of multilayer shell structures with both material and geometric non‐linearities are presented, and compared with existing results obtained from other shell elements and from a meshless method. It is shown that elements that did not pass the out‐of‐plane bending patch test could not provide accurate results, as compared to the present element formulation, which passed the out‐of‐plane bending patch test. The present element proves to be versatile and efficient in the modelling and analyses of general non‐linear composite multilayer shell structures. Copyright © 2005 John Wiley & Sons, Ltd.     

The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations

Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of drug molecules. The impact of excipients on the stability of olanzapine confirms that levels of impurities and degradants are limiting parameters and are therefore used for stability evaluation. The major degradation product of olanzapine was identified as 2-methyl-5,10-dihydro-4H-thieno[2,3-b][1,5]benzodiazepine-4-one (III). The structure of III was determined by using LC-MS, IR and NMR. Compatibility and stress stability results demonstrated that tablet formulations of olanzapine are sensitive to temperature and moisture. In samples protected from moisture, the increase in concentration of III was shown to be highly temperature dependent and the degradation followed zero-order kinetics. In addition, studies of olanzapine with excipients and in formulated tablets revealed polymorphic phase changes in some samples, influenced by a combination of stress temperature and humidity conditions. Polymorphic transitions were monitored using x-ray powder diffraction (XRPD) analysis and exhibited no correlation between the phase change (appearance of a new polymorph) and the degradation process.     

A four‐node corotational quadrilateral elastoplastic shell element using vectorial rotational variables

A four‐node corotational quadrilateral elastoplastic shell element is presented. The local coordinate system of the element is defined by the two bisectors of the diagonal vectors generated from the four corner nodes and their cross product. This local coordinate system rotates rigidly with the element but does not deform with the element. As a result, the element rigid‐body rotations are excluded in calculating the local nodal variables from the global nodal variables. The two smallest components of each nodal orientation vector are defined as rotational variables, leading to the desired additive property for all nodal variables in a nonlinear incremental solution procedure. Different from other existing corotational finite‐element formulations, the resulting element tangent stiffness matrix is symmetric owing to the commutativity of the local nodal variables in calculating the second derivative of strains with respect to these variables. For elastoplastic analyses, the Maxwell–Huber–Hencky–von Mises yield criterion is employed, together with the backward‐Euler return‐mapping method, for the evaluation of the elastoplastic stress state; the consistent tangent modulus matrix is derived. To eliminate locking problems, we use the assumed strain method. Several elastic patch tests and elastoplastic plate/shell problems undergoing large deformation are solved to demonstrate the computational efficiency and accuracy of the proposed formulation. Copyright © 2013 John Wiley & Sons, Ltd.     

Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis

Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this pharmacomodulation and obtained nanomolar active molecules (EC₅₀) against this pathogen. This gain in activity prompted us to evaluate the antibacterial activity of this family of molecules against other pathogenic bacteria, such as Neisseria gonorrhoeae and bacteria from the ESKAPE group. The results show that the novel molecules have selectively improved activity against C. trachomatis and demonstrate how the antichlamydial effect of fluoroquinolones can be enhanced.     

Perspectives on crowdsourcing annotations for natural language processing

Crowdsourcing has emerged as a new method for obtaining annotations for training models for machine learning. While many variants of this process exist, they largely differ in their methods of motivating subjects to contribute and the scale of their applications. To date, there has yet to be a study that helps the practitioner to decide what form an annotation application should take to best reach its objectives within the constraints of a project. To fill this gap, we provide a faceted analysis of crowdsourcing from a practitioner’s perspective, and show how our facets apply to existing published crowdsourced annotation applications. We then summarize how the major crowdsourcing genres fill different parts of this multi-dimensional space, which leads to our recommendations on the potential opportunities crowdsourcing offers to future annotation efforts.     

Mechanical behaviour of fired clay materials subjected to freeze–thaw cycles

The aim of this paper is to study the frost durability of fired clay materials. The behaviour of five fired clay materials with different physical and mechanical properties (porosity, permeability, mechanical strengths and elasticity modulus) subjected to freeze–thaw cycles is analysed. The strains of specimens and the evolution of the main properties with the number of cycles are assessed. The analysis shows that the pore distribution is not the only important parameter but that the tensile strength is also significant. A complete data bank is thus built up to study the effects of the physical and mechanical parameters on frost resistance and to determine how these parameters are affected by frost cycles. It will be possible to use these data to improve the modelling of coupled thermo-hydro-mechanical phenomena involved during the freezing and thawing process in porous media.     

Selective IR absorption in molecular nanofilms

We have formulated a microscopic theory of optical properties of ultrathin molecular films (nanofilms), i.e. quasi 2D systems parallel to XY planes bounded by two surfaces. Exposure of nanofilms to the external electromagnetic fields has result in creation of excitons - but different than bulk ones. Harmonic exciton states were calculated using the method of two-time, retarded, temperature dependent Green’s functions. It has been shown that two types of optical excitations can occur: bulk and surface exciton states. Exciton energy dispersion law shows discrete behavior with non-zero values. Analysis of the dielectric properties of these crystalline systems for low exciton concentration shows that the permittivity strongly depends on boundary parameters and the thickness of the film. In addition, permittivity shows very narrow and discrete dependence of external electromagnetic field frequency, which is a consequence of both resonance and quantum size effects. Influences of boundary conditions on optical characteristics (through analyses of dynamical absorption coefficient) of these nanostructures were specially and in details explored.