Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin‐3 Inhibitor

Glycan microarrays are useful tools for lectin glycan profiling. The use of a glycan microarray based on evanescent‐field fluorescence detection was herein further extended to the screening of lectin inhibitors in competitive experiments. The efficacy of this approach was tested with 2/3′‐mono‐ and 2,3′‐diaromatic type II lactosamine derivatives and galectins as targets and was validated by comparison with fluorescence anisotropy proposed as an orthogonal protein interaction measurement technique. We showed that subtle differences in the architecture of the inhibitor could be sensed that pointed out the preference of galectin‐3 for 2′‐arylamido derivatives over ureas, thioureas, and amines and that of galectin‐7 for derivatives bearing an α substituent at the anomeric position of glucosamine. We eventually identified a diaromatic oxazoline as a highly specific inhibitor of galectin‐3 versus galectin‐1 and galectin‐7.     

Chemical Reactions of Ultraphosphate Glasses with Water at Various Temperatures

The chemical reactions between P₂O₅-ZnO-H₂O ultraphosphate glasses and water were characterized between room temperature and 500°C, using thermogravimetry, differential scanning calorimetry, X-ray diffraction, and ³¹P nuclear magnetic resonance. Water adsorption and hydrolysis reactions of the glass leads to the formation of H₃PO₄ and crystalline ZnH₂P₂O₇ below 200°C. The rate of water adsorption increases, owing to the hygroscopicity of the hydrolysis products of the glass. Devitrification occurs at 250°C via surface reactions. The microstructure of the devitrified glass consists of crystalline Zn₂P₄O₁₂ and a liquid phase containing hydrolysis products of P₂O₅ like metaphosphoric acid (HPO₃) _n. Devitrification is finally followed by water desorption at higher temperatures.     

油气藏井间监测新技术及其应用

目前,井间监测技术正朝着将地层测量从近井区域推向储层深处这一方向发展。油气藏管理人员可以利用根据测量结果获得的层析成像来监测地层深处流体的流动情况。     

Effects of aggregate size on alkali–silica-reaction induced expansion

The macroscopic effects of ASR are linked to the damage state at the microstructure level. In this paper we used a combination of experiments and modelling to study the effect of aggregate size on the manifestation of ASR. There are two main ways in which the size of the aggregates can affect damage evolution: the propagation of cracks in aggregates of different sizes and the interactions between expanding and non-expanding aggregates in a densely packed microstructure. To assess these effects, concretes were cast with the same PSD but each with a different size class of reactive aggregates. Numerical simulations were used to model the mechanical interactions in single aggregates and in complete microstructures at the mesoscopic level. From the simulations a mechanism is proposed to explain the experimental observations. This suggests that: the expansion rate of ASR affected concrete depends on the fracture behaviour of individual aggregates in the early stage, and on the fracture behaviour of the paste in the later stages.     

Forced assembly by multilayer coextrusion to create oriented graphene reinforced polymer nanocomposites

A potential advantage of platelet-like nanofillers as nanocomposite reinforcements is the possibility of achieving two-dimensional stiffening through planar orientation of the platelets. The ability to achieve improved properties through in-plane orientation of the platelets is a challenge and, here, we present the first results of using forced assembly to orient graphene nanoplatelets in poly(methyl methacrylate)/polystyrene (PMMA/PS) and PMMA/PMMA multilayer films produced through multilayer coextrusion. The films exhibited a multilayer structure made of alternating layers of polymer and polymer containing graphene as evidenced by electron microscopy. Significant single layer reinforcement of 118% at a concentration of 2 wt % graphene was achieved—higher than previously reported reinforcement for randomly dispersed graphene. The large reinforcement is attributed to the planar orientation of the graphene in the individual polymer layers. Anisotropy of the stiffening was also observed and attributed to imperfect planar orientation of the graphene lateral to the extrusion flow.     

Room temperature electrical manipulation of giant magnetoresistance in spin valves exchange-biased with BiFeO3

Magnetoelectric multiferroics are attractive materials for the development of low-power electrically controlled spintronic devices. Here we report the optimization of the exchange bias as well as the giant magnetoresistance effect (GMR) of spin valves deposited on top of BiFeO(3)-based heterostructures. We show that the exchange bias can be electrically controlled through a change in the relative proportion of 109° domain walls and propose solutions toward a reversible process.     

3-D Reconstruction of Urban Scenes from Image Sequences

In this paper, we address the problem of the recovery of a realistic textured model of a scene from a sequence of images, without any prior knowledge either about the parameters of the cameras or about their motion. We do not require any knowledge of the absolute coordinates of some control points in the scene to achieve this goal. First, using various computer vision tools, we establish correspondences between the images and recover the epipolar geometry, from which we show how to compute the complete set of perspective projection matrices for all camera positions. Then, we proceed to reconstruct the geometry of the scene. We show how to rely on information of the scene such as parallel lines or known angles in order to reconstruct the geometry of the scene up to, respectively, an unknown affine transformation or an unknown similitude. Alternatively, if this information is not available, we can still recover the Euclidean structure of the scene through the techniques of self-calibration. The scene geometry is modeled as a set of polyhedra. Textures to be mapped on the scene polygons are extracted automatically from the images. We show how several images can be combined through mosaicing in order to automatically remove visual artifacts such as pedestrians or trees from the textures.This vision system has been implemented as a vision server, which provides to a CAD-CAM modeler geometry or texture information extracted from the set of images. The whole system allows efficient and fast production of scene models of high quality for such applications as simulation, virtual, or augmented reality.     

Generalized disjunction decomposition for evolvable hardware.

Evolvable hardware (EHW) refers to self-reconfiguration hardware design, where the configuration is under the control of an evolutionary algorithm (EA). One of the main difficulties in using EHW to solve real-world problems is scalability, which limits the size of the circuit that may be evolved. This paper outlines a new type of decomposition strategy for EHW, the "generalized disjunction decomposition" (GDD), which allows the evolution of large circuits. The proposed method has been extensively tested, not only with multipliers and parity bit problems traditionally used in the EHW community, but also with logic circuits taken from the Microelectronics Center of North Carolina (MCNC) benchmark library and randomly generated circuits. In order to achieve statistically relevant results, each analyzed logic circuit has been evolved 100 times, and the average of these results is presented and compared with other EHW techniques. This approach is necessary because of the probabilistic nature of EA; the same logic circuit may not be solved in the same way if tested several times. The proposed method has been examined in an extrinsic EHW system using the (1 + lambda) evolution strategy. The results obtained demonstrate that GDD significantly improves the evolution of logic circuits in terms of the number of generations, reduces computational time as it is able to reduce the required time for a single iteration of the EA, and enables the evolution of larger circuits never before evolved. In addition to the proposed method, a short overview of EHW systems together with the most recent applications in electrical circuit design is provided.     

Leaching behaviour of unirradiated high temperature reactor (HTR) UO2-ThO2 mixed oxides fuel particles

The dissolution of different mixed oxide (U, Th)O₂ particles under reducing conditions has been studied using a continuous flow-through reactor. The U/Th ratio seems to have no or little influence on the normalised leaching rate of thorium or uranium, The release rate of uranium from the outer surface of a Th rich matrix seems to follow the behaviour of pure UO₂ even though U is a minor component in these phases and the dissolution rate of Th is much lower. After long time U concentrations will become depleted at the solids surface and it will be expected that U release rates will become controlled by the release rates of thorium (rates at neutral pH < 10⁻⁶ g m⁻² d⁻¹). Under reducing conditions, the matrix of HTR fuel particles presents significant intrinsic radionuclide confinement properties.