ESMRMB 2017, 34th Annual Scientific Meeting,Barcelona, ES,October 19–October 21: Abstracts,Thursday

Objective

Current magnetic resonance imaging (MRI) axon diameter measurements rely on the pulsed gradient spin-echo sequence, which is unable to provide diffusion times short enough to measure small axon diameters. This study combines the AxCaliber axon diameter fitting method with data generated from Monte Carlo simulations of oscillating gradient spin-echo sequences (OGSE) to infer micron-sized axon diameters, in order to determine the feasibility of using MRI to infer smaller axon diameters in brain tissue.

Materials and methods

Monte Carlo computer simulation data were synthesized from tissue geometries of cylinders of different diameters using a range of gradient frequencies in the cosine OGSE sequence . Data were fitted to the AxCaliber method modified to allow the new pulse sequence. Intra- and extra-axonal water were studied separately and together.

Results

The simulations revealed the extra-axonal model to be problematic. Rather than change the model, we found that restricting the range of gradient frequencies such that the measured apparent diffusion coefficient was constant over that range resulted in more accurate fitted diameters. Thus a careful selection of frequency ranges is needed for the AxCaliber method to correctly model extra-axonal water, or adaptations to the method are needed. This restriction helped reduce the necessary gradient strengths for measurements that could be performed with parameters feasible for a Bruker BG6 gradient set. For these experiments, the simulations inferred diameters as small as 0.5 μm on square-packed and randomly packed cylinders. The accuracy of the inferred diameters was found to be dependent on the signal-to-noise ratio (SNR), with smaller diameters more affected by noise, although all diameter distributions were distinguishable from one another for all SNRs tested.

Conclusion

The results of this study indicate the feasibility of using MRI with OGSE on preclinical scanners to infer small axon diameters.

     

Fitting interrelated datasets: metabolite diffusion and general lineshapes

Objective

Simultaneous modeling of true 2-D spectroscopy data, or more generally, interrelated spectral datasets has been described previously and is useful for quantitative magnetic resonance spectroscopy applications. In this study, a combined method of reference-lineshape enhanced model fitting and two-dimensional prior-knowledge fitting for the case of diffusion weighted MR spectroscopy is presented.

Materials and methods

Time-dependent field distortions determined from a water reference are applied to the spectral bases used in linear-combination modeling of interrelated spectra. This was implemented together with a simultaneous spectral and diffusion model fitting in the previously described Fitting Tool for Arrays of Interrelated Datasets (FiTAID), where prior knowledge conditions and restraints can be enforced in two dimensions.

Results

The benefit in terms of increased accuracy and precision of parameters is illustrated with examples from Monte Carlo simulations, in vitro and in vivo human brain scans for one- and two-dimensional datasets from 2-D separation, inversion recovery and diffusion-weighted spectroscopy (DWS). For DWS, it was found that acquisitions could be substantially shortened.

Conclusion

It is shown that inclusion of a measured lineshape into modeling of interrelated MR spectra is beneficial and can be combined also with simultaneous spectral and diffusion modeling.

     

Sensitive magnetic field sensor using 2D magnetic photonic crystal slab waveguide based on BIG/GGG structure

A kind of magnetic field sensor (MFS) using a two-dimensional (2D) magnetic photonic crystal (MPC) slab waveguide as the sensing structure is proposed and investigated numerically. The slab structure is based on bismuth iron garnet (BIG), a well-known magnetic material with effective magnetooptical (MO) properties, sandwiched with gadolinium gallium garnet (GGG) as substrate. The complete photonic bandgap (PBG) of the 2D MPC is simulated and optimized for realization of polarization-independent waveguides. The simulation results show that the width and position of the complete PBG depend on the thickness of the BIG slab and the radius of the air holes used in the design. By reducing the lightwave propagation losses and enhancing the mode conversion ratio, increased sensitivity is obtained. Based on the Faraday effect, a good linear relationship is observed between the normalized output light intensity and the magnetic field strength as the gyrotropy parameter g is varied from 0.13 to 0.19, a g-range used as the sensor dynamic range. The remarkable enhancement in sensing performance due to the MO effect makes the designed device suitable for magnetic field sensing. The results are discussed to provide a basis for investigation of 2D MPC slab waveguides based on the same structure, which are of particular interest for development of highly sensitive MFSs.     

Hendrick Petrus Berlage's villas

Hendrick Berlage is known to architectural history mainly for his Amsterdam Stock Exchange of 1903. This is often celebrated as a proto-modernist work in a rationalist spirit, an oversimplified view, for the building had a conventionally eclectic start and was the fruit of long struggle and many revisions. The development of Berlage's architectural ideas during the period of its gestation is chronicled in a fascinating way by a series of private villas built for friends who were artists and intellectuals. Completed year by year, they run right through the 1890s, showing Berlage's changing concerns with the articulation of content, the expression of construction, the application of controlling geometry, and the development of architectural space.     

国家的门脸儿——南非使领馆设计

国家强大了!国人有钱了!经过30年的快速发展,中国在世界的地位发生了巨大的变化,中国人在外国人面前腰杆也挺起来了.然而在人们对中国经济的飞跃发展充满好奇和羡慕的同时,也对中国人处事态度的变化产生疑虑和担心.外交使团代表着国家的风范,使领馆建筑也代表着国家的形象.因此,设计使领馆建筑多少担负着表达中国精神和传递文化品味的重任.9年前我们有幸承担了中国驻南非使领馆的设计工作,在创作中得到外交部和使馆各级领导的大力支持,他们彬彬有礼的作风、既相互尊重又坚持原则的办事态度以及对国际文化交流的设想,给了我们很大的启发和激励,使我们明确了尊重环境、和谐内敛、追求精致典雅文化气质的创作思路,设计工作由此顺利展开.     

Design and manufacture of high-filling-efficiency microfluidic devices

In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to simulate the machining process. The simulated tooling file was then loaded into a CNC milling machine for mold production. The fabricated metal mold was used for pouring polydimethylsiloxane (PDMS) to obtain high-filling-efficiency microfluidic structures. Finally, plasma-assisted packaging was conducted to tightly bind the PDMS microfluidic structure to the glass substrate. Experimental results showed that the additional semicircular filling structure and expended fill-entry structure can efficiently enhance filling efficiency of the microchannel device. The incubation well array can be completely filled at a relatively short filling time. The proposed highly efficient filling microfluidic device possesses advantages, such as feasibility for mass production and cost effectiveness.     

Evaluation of grinding wheel loading phenomena by using acoustic emission signals

In the industrial manufacturing field, machining is a major process. Machining operations involve grinding, drilling, milling, turning, pressing, molding, and so on. Among these operations, grinding is the most precise and complicated process. The surface condition of the grinding wheel plays an important role in grinding performance, and the identification of grinding wheel loading phenomena during the grinding process is critical. Accordingly, this present study describes a measurement method based on the acoustic emission (AE) technique to characterize the loading phenomena of a Si₂O₃ grinding wheel for the grinding mass production process. The proposed measurement method combines the process-integrated measurement of AE signals, offline digital image processing, and surface roughness measurement of the ground workpieces for the evaluation of grinding wheel loading phenomena. The experimental results show that the proposed measurement method provides a quantitative index from the AE signals to evaluate the grinding wheel loading phenomena online for the grinding mass production process, and this quantitative index is determined via some experiments in advance in the same grinding environment to help the monitoring and controlling of the grinding process.     

Research on quality improvement of the cross section cut by abrasive water jet based on secondary cutting

A manufacturing system comprises production processes and building services, both of which are supplied by different energy carriers as well as raw materials and water. These resources interact according to complex relationships and are converted into products for sale and waste flows. Holistic resource accounting allows the analyst to consider the dynamic relationships between these components, including the strong interdependence between energy and water, which has been called the energy-water nexus. Exergy analysis is a method that accounts for mass and both the quantity and quality of energy, while allowing analysis on a common basis, and for this reason, it is used increasingly to analyse resource consumption in manufacturing systems; however, it has rarely been used to consider water flows alongside energy and material flows. The main contribution of this paper is the presentation of modelling water flows in terms of exergy in the context of sustainable manufacturing. Using this technique in combination with previously developed exergy-based methods, the result is a truly holistic resource accounting method for factories based on exergy analysis that incorporates water flows. The method is illustrated using a case study of a food factory in which a 4.1% reduction in resource use is shown to be possible by employing anaerobic digester in an effluent water treatment process. The benefits of this technology option would have been underestimated compared to the benefits of waste heat capture if an analysis based on mass and energy balances alone had been used. The scientific value of this paper is the demonstration of the relatively high exergy content of effluent flows, which should therefore be regarded as potentially valuable resources. The analytical method presented is therefore of value to a wide range of industries beyond the food industry.     

Post-processor development for a turning and milling composite machine tool

The accomplishment of a turning and five-axis milling in only one setup is extremely useful and is possible on a turning and milling composite machine tool. In this work, we present a control algorithm and develop a post-processor for this machine, which has six linear and three rotary axes. To calculate a generalized kinematics model, coordinate systems are established by analyzing the basic kinematic chain relation of the turning and milling composite machine tool. The two vectors, which control the motions of the cutter contact workpiece, are simultaneously transformed to provide the algorithms of the rotary angles and motion coordinate. A special post-processor written in JAVA language is developed according to the proposed algorithm. To evaluate the effectiveness and accuracy of the developed post-processor, a specimen (blade) is used in the cutting simulation and real machining experiment. Experimental results showed the effectiveness and accuracy of the proposed algorithm. Furthermore, Compatibility is improved by adding new functions such as change of target machine, cutter location data change, workpiece origin offset, and cutting feed rate control.