Evolution of Microstructure of Cold‐Spray Aluminum Coatings on Al2O3 Substrates

Electron backscatter diffraction is used to study the microstructural evolution of cold‐spray aluminum coatings on Al₂O₃ substrates. The influence of powder purity and substrate heating on the kernel average misorientation and the distribution of low‐angle grain boundaries in as‐sprayed and annealed coatings are discussed in terms of dynamic recovery and dynamic recrystallization.     

Critical Review of Deflection Formulas for FRP-RC Members

The design of fiber-reinforced polymer reinforced concrete (FRP-RC) is typically governed by serviceability limit state requirements rather than ultimate limit state requirements as conventional reinforced concrete is. Thus, a method is needed that can predict the expected service load deflections of fiber-reinforced polymer (FRP) reinforced members with a reasonably high degree of accuracy. Nine methods of deflection calculation, including methods used in ACI 440.1R-03, and a proposed new formula in the next issue of this design guide, CSA S806-02 and ISIS M03-01, are compared to the experimental deflection of 197 beams and slabs tested by other investigators. These members are reinforced with aramid FRP, glass FRP, or carbon FRP bars, have different reinforcement ratios, geometric and material properties. All members were tested under monotonically applied load in four point bending configuration. The objective of the analysis in this paper is to determine a method of deflection calculation for FRP RC members, which is the most suitable for serviceability criteria. The analysis revealed that both the modulus of elasticity of FRP and the relative reinforcement ratio play an important role in the accuracy of the formulas.     

The structure of iron superoxide dismutase from Pseudomonas ovalis complexed with the inhibitor azide

The 2.9 Å resolution structure of iron superoxide dismutase(FeSOD) (EC 1.15.1.1 [EC] ) from Pseudomonas ovalis complexed withthe inhibitor azide was solved. Comparison of this structurewith free enzyme shows that the inhibitor is bound at the opencoordination position of the iron, with a bond length of 2.0Å. The metal moves by 0.4 Å into the trigonal planeto produce an orthogonal geometry at the iron. Binding of theinhibitor also causes a movement of the axial ligand (histidine26) away from the metal, a lengthening of the iron—histidinebond, and a rotation of the histidine 74 ring. The inhibitorpossesses contacts in the binding pocket with a pair of conservedtryptophan residues and with the side chains of tyrosine 34and glutamine 70. This glutamine is conserved between all FeSODs,but is absent in MnSOD. Comparisons with MnSOD show that a differentglutamine which possesses the same interactions in the activesite as Gln70 in FeSOD is conserved at position 154 in the overallSOD sequence, implying that while manganese and FeSODs are structuralhomologues in a global sense, their functional and evolutionaryrelationship is that of second-site mutation revertants.     

Piezoelectric coefficients of -alanine doped TGS crystals

Double beam laser interferometry has been used to study small displacement of LATGS crystals caused by the converse piezoelectric effect. All eight nonzero mutually independent piezoelectric coefficients d_iλ have been derived. The temperature dependence of the piezoelectric coefficient d₂₂ has been measured using the single beam Michelson interferometer. The phase transition temperature was determined near 324 K.     

Biocompatibility of Amine‐Functionalized Silica Nanoparticles: The Role of Surface Coverage

Here, amorphous silica nanoparticles (NPs), one of the most abundant nanomaterials, are used as an example to illustrate the utmost importance of surface coverage by functional groups which critically determines biocompatibility. Silica NPs are functionalized with increasing amounts of amino groups, and the number of surface exposed groups is quantified and characterized by detailed NMR and fluorescamine binding studies. Subsequent biocompatibility studies in the absence of serum demonstrate that, irrespective of surface modification, both plain and amine‐modified silica NPs trigger cell death in RAW 264.7 macrophages. The in vitro results can be confirmed in vivo and are predictive for the inflammatory potential in murine lungs. In the presence of serum proteins, on the other hand, a replacement of only 10% of surface‐active silanol groups by amines is sufficient to suppress cytotoxicity, emphasizing the relevance of exposure conditions. Mechanistic investigations identify a key role of lysosomal injury for cytotoxicity only in the presence, but not in the absence, of serum proteins. In conclusion, this work shows the critical need to rigorously characterize the surface coverage of NPs by their constituent functional groups, as well as the impact of serum, to reliably establish quantitative nanostructure activity relationships and develop safe nanomaterials.     

New approach to local anodic oxidation of semiconductor heterostructures

We have experimentally explored a new approach to local anodic oxidation (LAO) of a semiconductor heterostructures by means of atomic force microscopy (AFM). We have applied LAO to an InGaP/AlGaAs/GaAs heterostructure. Although LAO is usually applied to oxidize GaAs/AlGaAs/GaAs-based heterostructures, the use of the InGaP/AlGaAs/GaAs system is more advantageous. The difference lies in the use of different cap layer materials: Unlike GaAs, InGaP acts like a barrier material with respect to the underlying AlGaAs layer and has almost one order of magnitude lower density of surface states than GaAs. Consequently, the InGaP/AlGaAs/GaAs heterostructure had the remote Si-delta doping layer only 6.5nm beneath the surface and the two-dimensional electron gas (2DEG) was confined only 23.5nm beneath the surface. Moreover, InGaP unaffected by LAO is a very durable material in various etchants and allows us to repeatedly remove thin portions of the underlying AlGaAs layer via wet etching. This approach influences LAO technology fundamentally: LAO was used only to oxidize InGaP cap layer to define very narrow ( approximately 50nm) patterns. Subsequent wet etching was used to form very narrow and high-energy barriers in the 2DEG patterns. This new approach is promising for the development of future nano-devices operated both at low and high temperatures.     

Ist die Institutionalisierung und Legalisierung der Suizidbeihilfe gefährlich?

Definition of the problem

The topic of this essay is the chances and risks of a possible legalization of assistance to suicide.

Arguments

Counterarguments against this legalization are discussed and analyzed in three thematic groups: "Slippery slope" arguments, arguments of "moral pressure", and the fear of the "loss of solidarity in society" and the "endangering of the physician-patient relationship".

Conclusion

These counterarguments prove to be non-cogent in the case of criteria and standards of suicide assistance in legal form being developed and controlled by the government.