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101.
Babčanová Dagmar Šujanová Jana Cagáňová Dagmar Horňáková Natália Hrablik Chovanová Henrieta 《Wireless Networks》2021,27(3):1693-1700
Wireless Networks - The purpose of the paper is to point out the importance of analysing data obtained from social media through the qualitative data analysis software. The main goal of conducted... 相似文献
102.
Dagmar Ammelt Alica Lammerskitten Artur Wiktor Francisco J. Barba Stefan Toepfl Oleksii Parniakov 《International Journal of Food Science & Technology》2021,56(4):1777-1787
The effect of pulsed electric fields (PEF) on the cell disintegration index (Zp), the freeze-drying process and the final product quality of red beet and pineapple tissue was studied. Red beets and pineapples were PEF-treated at an electric field strength of 1.07 kV/cm and specific energy inputs of 1 kJ/kg and 4 kJ/kg (PEF1 and PEF2, respectively). Freeze-drying was performed at a pressure of 1 mbar and heating plate temperature of 50 °C for red beet and 40 °C for pineapple. The quality of freeze-dried tissue was evaluated by the analysis of residual moisture content, macrostructure, texture, colour and rehydration properties. For freeze-dried red beets, the betalain content from extracts was studied. It could be stated that PEF pre-treatment had no significant influence on drying time reduction, however significantly improved the final quality of freeze-dried product. Moreover, the effect of PEF was strongly depending on type of plant material used. 相似文献
103.
104.
Firas J. Hmood Janka Wilbig Dagmar Nicolaides Andrea Zocca Jens Günster 《Ceramics International》2021,47(14):20045-20050
This study suggests a tool for a better control on the sintering/crystallization of 3D-printed bioactive glass-ceramics bodies. A small cantilever in form of a bar with square cross section attached to a base and inclined 34° with the horizon, was used to monitor the viscous flow and sintering/crystallization headway of a glass-ceramic systems. 3D printing and sintering of bioactive glass-ceramics is of great interest for medical care applications. Viscous flow ensures sufficient densification of the typically low density printed green bodies, while crystallization prevents the structure from collapsing under the gravitational load. As a model system, a bioactive glass called BP1 (48.4 SiO2, 1 B2O3, 2 P2O5, 36.6 CaO, 6.6 K2O, 5.6 Na2O (mol%)), which has a chemical composition based on that of ICIE16, was employed in this work. In addition, ICIE16 was used as a reference glass. The results show that the suggested design is a very promising tool to track the real-time deformation of 3D printed glass-ceramic specimens and gives a good indication for the onset of crystallization as well. 相似文献
105.
Irene Schilcher Julia T. Stadler Margarete Lechleitner Andelko Hrzenjak Andrea Berghold Gudrun Pregartner Marie Lhomme Michael Holzer Melanie Korbelius Florian Reichmann Anna Springer Christian Wadsack Tobias Madl Dagmar Kratky Anatol Kontush Gunther Marsche Saa Frank 《International journal of molecular sciences》2021,22(2)
Endothelial lipase (EL) is a strong modulator of the high-density lipoprotein (HDL) structure, composition, and function. Here, we examined the impact of EL on HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity in vitro and in vivo. The incubation of HDL with EL-overexpressing HepG2 cells decreased HDL size, PON1 content, and AE activity. The EL modification of HDL did not diminish the capacity of HDL to associate with PON1 when EL-modified HDL was incubated with PON1-overexpressing cells. The overexpression of EL in mice significantly decreased HDL serum levels but unexpectedly increased HDL PON1 content and HDL AE activity. Enzymatically inactive EL had no effect on the PON1 content of HDL in mice. In healthy subjects, EL serum levels were not significantly correlated with HDL levels. However, HDL PON1 content was positively associated with EL serum levels. The EL-induced changes in the HDL-lipid composition were not linked to the HDL PON1 content. We conclude that primarily, the interaction of enzymatically active EL with HDL, rather than EL-induced alterations in HDL size and composition, causes PON1 displacement from HDL in vitro. In vivo, the EL-mediated reduction of HDL serum levels and the consequently increased PON1-to-HDL ratio in serum increase HDL PON1 content and AE activity in mice. In humans, additional mechanisms appear to underlie the association of EL serum levels and HDL PON1 content. 相似文献
106.
Horňáková Natália Jurík Lukáš Hrablik Chovanová Henrieta Cagáňová Dagmar Babčanová Dagmar 《Wireless Networks》2021,27(3):1683-1691
Wireless Networks - The paper deals with handling equipment that can be used to transport/handle the final products in a selected industrial enterprise. The suitable handling equipment listed in... 相似文献
107.
Kathrin Tan Christian Jäger Dr. Hagen Körschgen Dr. Stefanie Geissler Dr. Dagmar Schlenzig Dr. Mirko Buchholz Prof. Dr. Walter Stöcker Dr. Daniel Ramsbeck 《ChemMedChem》2021,16(6):976-988
Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug-discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. Moreover, some compounds already exhibited higher activity against individual astacin proteinases compared to recently reported inhibitors and also a favorable off-target selectivity profile, thus qualifying them as very suitable chemical probes for target validation. 相似文献
108.
Mobile Networks and Applications - New solutions are more and more needed due to the fact that new trends in technology, communication, global knowledge, new managerial approaches, building new... 相似文献
109.
Dr. Dagmar Schmitz 《Ethik in der Medizin》2005,17(4):316-321
110.
One of the essential properties of mammalian, including sperm, plasma membranes is a stable transversal lipid asymmetry with the aminophospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), typically in the inner, cytoplasmic leaflet. The maintenance of this nonrandom lipid distribution is important for the homeostasis of the cell. To clarify the relevance of lipid asymmetry to sperm function, we have studied the localization of PS in boar sperm cell membranes. By using labeled annexin V as a marker for PS and propidium iodide (PI) as a stain for nonviable cells in conjunction with different methods (flow cytometry, fluorescence and electron microscopy), we have assessed the surface exposure of PS in viable cells during sperm genesis, that is, before and during capacitation as well as after acrosome reaction. An approach was set up to address also the presence of PS in the outer acrosome membrane. The results show that PS is localized in the cytoplasmic leaflet of the plasma membrane as well as on the outer acrosome membrane. Our results further indicate the cytoplasmic localization of PS in the postacrosomal region. During capacitation and acrosome reaction of spermatozoa, PS does not become exposed on the outer surface of the viable cells. Only in a subpopulation of PI-positive sperm cells does PS became accessible upon capacitation. The stable cytoplasmic localization of PS in the plasma membrane, as well as in the outer acrosome membrane, is assumed to be essential for a proper genesis of sperm cells during capacitation and acrosome reaction. 相似文献