The RE-UWA approach to recover user centered conceptual models from Web applications

Large-scale Web Applications, especially those intended to publish contents and provide information to its users, are by nature subject to continuous and fast changes. This often means fast obsolescence of the design documentation and a lot of effort required to comprehend the application when performing maintenance and evolution tasks. This paper presents a reverse engineering approach for Web Applications enabling the semi-automatic recovery of user-centered conceptual models describing, from a user perspective, key aspects, such as the delivered contents and navigational paths. The abstracted models are formalized according to the Ubiquitous Web Applications (UWA) design methodology, but any other design method for Web Applications could be used instead. The paper describes the recovery process, a tool developed to support the process, and the results from a case study conducted to validate the approach on a set of real world Web Applications.     

Robust fault and icing diagnosis in unmanned aerial vehicles using LPV interval observers

This paper proposes a linear parameter varying (LPV) interval unknown input observer for the robust fault diagnosis of actuator faults and ice accretion in unmanned aerial vehicles (UAVs) described by an uncertain model. The proposed interval observer evaluates the set of values for the state, which are compatible with the nominal fault‐free and icing‐free operation and can be designed in such a way that some information about the nature of the unknown inputs affecting the system can be obtained, thus allowing the diagnosis to be performed. The proposed strategy has several advantages. First, the LPV paradigm allows taking into account operating point variations. Second, the noise rejection properties are enhanced by the presence of the integral term. Third, the interval estimation property guarantees the absence of false alarms. Linear matrix inequality–based conditions for the analysis/design of these observers are provided in order to guarantee the interval estimation of the state and the boundedness of the estimation. The developed theory is supported by simulation results, obtained with the uncertain model of a Zagi Flying Wing UAV, which illustrate the strong appeal of the methodology for identifying correctly unexpected changes in the system dynamics due to actuator faults or icing.     

Space–Time Signal Analysis and the 3D Shearlet Transform

In this work, we address the problem of analyzing video sequences by representing meaningful local space–time neighborhoods. We propose a mathematical model to describe relevant points as local singularities of a 3D signal, and we show that these local patterns can be nicely highlighted by the 3D shearlet transform, which is at the root of our work. Based on this mathematical framework, we derive an algorithm to represent space–time points which is very effective in analyzing video sequences. In particular, we show how points of the same nature have a very similar representation, allowing us to compute different space–time primitives for a video sequence in an unsupervised way.     

Nonionic surfactants. Regioselective synthesis of fatty acid esters of α- and β-glucopyranose

Lipophilic esters of saccharides belong to the family of nonionic surfactants widely employed in pharmaceutical and cosmetics formulations. A very simple method is presented whereby 6-O-esters of α- and β-glucose can be prepared and isolated. Good results have been obtained in the synthesis of 6-O-oleyl derivatives by simple acylation with appropriate oleyl chloride. The condensing agent bis(2-oxo-3-oxazolidinyl) phosphinic chloride (BOP-Cl) allows the preparations of the same esters with better regioselectivity but with yields strongly dependent on the aliphatic chain length of the carboxylic acids employed.     

Highly Sensitive,Anisotropic, and Reversible Stress/Strain‐Sensors from Mechanochromic Nanofiber Composites

Mechanochromic polymeric systems are intensively investigated for real‐time stress detection applications. However, an effective stress‐sensing material must respond to low deformation with a detectable color change that should be quickly reversible upon force unloading. In this work, mechanochromic nanofibers made by electrospinning are used to produce mechanochromic nanofiber/poly(dimethylsiloxane) (PDMS) composites with isotropic and anisoptropic response. Due to chain alignment of spiropyran copolymer chains within the nanofibers, only very small strains are required to yield a mechanochromic response. Composites with aligned and isotropic nanofibers show anisotropic and isotropic mechanochromic behavior, respectively. Due to the special substitution pattern of spiropyran in the copolymer, the mechanochromic response of these nanofiber/PDMS composites shows fast reversibility upon force unloading. The outstanding benefit of using highly sensitive mechanochromic nanofibers as filler in composite materials allows the detection of directional stress and strain, and it is a step forward in the development of smart, mechanically responsive materials.     

Comments on “A new model for calculating the input impedanceof coax-fed circular microstrip antennas with and without airgaps” [and reply]

For original paper by Abboud et al. see IEEE Trans. Antennas Propagat., vol.38, p.1882-5 (1990). In the original paper, the resonance frequency of coax-fed circular microstrip antennas with and without air gaps has been modeled (in its Section III) by incorporating and rearranging some results previously reported by others. The present author, while working with the formulas of that Section III noticed a discrepancy in (8) and (9). This has been investigated thoroughly and the observations are presented. A brief reply is given by Damiano et al     

Definition of IgG Subclass-Specific Glycopatterns in Idiopathic Membranous Nephropathy: Aberrant IgG Glycoforms in Blood

The podocyte injury, and consequent proteinuria, that characterize the pathology of idiopathic membranous nephropathy (IMN) is mediated by an autoimmune reaction against podocyte antigens. In particular, the activation of pathways leading to abundant renal deposits of complement is likely to involve the binding of mannose-binding lectin (MBL) to aberrant glycans on immunoglobulins. To obtain a landscape of circulatory IgG Fc glycosylation characterizing this disease, we conducted a systematic N-glycan profiling study of IgG1, 2, and 4 by mass spectrometry. The cohort included 57 IMN patients, a pathological control group with nephrotic syndrome (PN) (n = 20), and 88 healthy control subjects. The effect of sex and age was assessed in all groups and controlled by rigorous matching. Several IgG Fc glycan traits were found to be associated with IMN. Interestingly, among them, only IgG4-related results were specific for IMN and not for PN. Hypo-galactosylation of IgG4, already shown for IMN, was observed to occur in the absence of core fucose, in line with a probable increase of pro-inflammatory IgG. In addition, elevated levels of fucosylated IgG4, along with low levels of hybrid-type glycans, were detected. Some of these IgG4 alterations are likely to be more pronounced in high PLA2R (phospholipase A2 receptor) patients. IgG Fc glycosylation patterns associated with IMN warrant further studies of their role in disease mechanisms and may eventually enrich the diagnostic spectrum regarding patient stratification.     

Design,Realization, and Characterization of Advanced Adhesives for Joining Ultra‐Stable C/C Based Components

The aim of this work is to develop high‐performance adhesives to join carbon fiber reinforced composites (C/C) for use in aerospace applications; in order to guarantee sound mechanical strength, a low coefficient of thermal expansion, and ease of application on large components. Several different adhesive formulations, based on phenolic or cyanate‐ester resins (charged with the maximum experimentally feasible amount of carbon‐based fillers), are developed and tested. The measurements of the lap shear strength at room temperature of the C/C joined by means of one phenolic and one cyanate ester‐based resin demonstrates that these formulations are the most suitable for the given application. A complete characterization, by means of viscosimetry, dilatometry, and thermal gravimetric analysis, coupled with gas analysis by means of mass spectroscopy, confirms that the phenolic‐based formulation is the most promising joining material. A nano‐indenter is used to obtain its Young modulus and hardness, both inside the joint and as a bulk cured adhesive.     

Multiple Roles for Cytokines in Atopic Dermatitis: From Pathogenic Mediators to Endotype-Specific Biomarkers to Therapeutic Targets

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which generally presents with intense itching and recurrent eczematous lesions. AD affects up to 20% of children and 10% of adults in high-income countries. The prevalence and incidence of AD have increased in recent years. The onset of AD mostly occurs in childhood, although in some cases AD may persist in adult life or even manifest in middle age (adult-onset AD). AD pathophysiology is made of a complex net, in which genetic background, skin barrier dysfunction, innate and adaptive immune responses, as well as itch contribute to disease development, progression, and chronicization. One of the most important features of AD is skin dehydration, which is mainly caused by filaggrin mutations that determine trans-epidermal water loss, pH alterations, and antigen penetration. In accordance with the “outside-inside” theory of AD pathogenesis, in a context of an altered epidermal barrier, antigens encounter epidermal antigen presentation cells (APCs), such as epidermal Langerhans cells and inflammatory epidermal dendritic cells, leading to their maturation and Th-2 cell-mediated inflammation. APCs also bear trimeric high-affinity receptors for immunoglobulin E (IgE), which induce IgE-mediated sensitizations as part of pathogenic mechanisms leading to AD. In this review, we discuss the role of cytokines in the pathogenesis of AD, considering patients with various clinical AD phenotypes. Moreover, we describe the cytokine patterns in patients with AD at different phases of the disease evolution, as well as in relation to different phenotypes/endotypes, including age, race, and intrinsic/extrinsic subtypes. We also discuss the outcomes of current biologics for AD, which corroborate the presence of multiple cytokine axes involved in the background of AD. A deep insight into the correlation between cytokine patterns and the related clinical forms of AD is a crucial step towards increasingly personalized, and therefore more efficient therapy.