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641.
Dr. Eden L. Sikorski Dr. Janessa Wehr Noel J. Ferraro Sophia M. Rizzo Prof. Marcos M. Pires Prof. Damien Thévenin 《Chembiochem : a European journal of chemical biology》2022,23(8):e202100521
Current immunotherapeutics often work by directing components of the immune system to recognize biomarkers on the surface of cancer cells to generate an immune response. However, variable changes in biomarker distribution and expression can result in inconsistent patient response. The development of a more universal tumor-homing strategy has the potential to improve selectivity and extend therapy to cancers with decreased expression or absence of specific biomarkers. Here, we designed a bifunctional agent that exploits the inherent acidic microenvironment of most solid tumors to selectively graft the surface of cancer cells with a formyl peptide receptor ligand (FPRL). Our approach is based on the pH(Low) insertion peptide (pHLIP), a unique peptide that selectively targets tumors in vivo by anchoring to cancer cells in a pH-dependent manner. We establish that selectively remodeling cancer cells with a pHLIP-based FPRL activates formyl peptide receptors on recruited immune cells, potentially initiating an immune response towards tumors. 相似文献
642.
Salvatore Teresi Nicolas Sebe Jessy Patterson Théo Frottier Aurélie Kandazoglou Paul Noël Paolo Sgarro Damien Térébénec Nicolas Bernier Françoise Hippert Jean-Philippe Attané Laurent Vila Pierre Noé Maxen Cosset-Chéneau 《Advanced functional materials》2023,33(44):2303878
Driving a spin-logic circuit requires the production of a large output signal by spin-charge interconversion in spin-orbit readout devices. This should be possible by using topological insulators, which are known for their high spin-charge interconversion efficiency. However, high-quality topological insulators have so far only been obtained on a small scale, or with large scale deposition techniques that are not compatible with conventional industrial deposition processes. The nanopatterning and electrical spin injection into these materials have also proven difficult due to their fragile structure and low spin conductance. The fabrication of a spin-orbit readout device from the topological insulator Sb2Te3 deposited by large-scale industrial magnetron sputtering on SiO2 is presented. Despite a modification of the Sb2Te3 layer structural properties during the device nanofabrication, a sizeable output voltage is measured that can be unambiguously ascribed to a spin-charge interconversion process. The results pave the way for the integration of layered van der Waals materials in spin-logic devices. 相似文献
643.
Damien van de Berg Panagiotis Petsagkourakis Nilay Shah Ehecatl Antonio del Rio-Chanona 《American Institute of Chemical Engineers》2023,69(4):e17977
While decomposition techniques in mathematical programming are usually designed for numerical efficiency, coordination problems within enterprise-wide optimization are often limited by organizational rather than numerical considerations. We propose a “data-driven” coordination framework which manages to recover the same optimum as the equivalent centralized formulation while allowing coordinating agents to retain autonomy, privacy, and flexibility over their own objectives, constraints, and variables. This approach updates the coordinated, or shared, variables based on derivative-free optimization (DFO) using only coordinated variables to agent-level optimal subproblem evaluation “data.” We compare the performance of our framework using different DFO solvers (CUATRO, Py-BOBYQA, DIRECT-L, GPyOpt) against conventional distributed optimization (ADMM) on three case studies: collaborative learning, facility location, and multiobjective blending. We show that in low-dimensional and nonconvex subproblems, the exploration-exploitation trade-offs of DFO solvers can be leveraged to converge faster and to a better solution than in distributed optimization. 相似文献
644.
645.
Vincent Polewczyk Moussa Mezhoud Martando Rath Oualyd El-Khaloufi Ferdinando Bassato Arnaud Fouchet Wilfrid Prellier Mathieu Frégnaux Damien Aureau Luca Braglia Giovanni Vinai Piero Torelli Ulrike Lüders 《Advanced functional materials》2023,33(31):2301056
In the search of low cost and more efficient electronic devices, here the properties of SrVO3 transparent conductor oxide (TCO) thin film are investigated, both visible-range optically transparent and highly conductive, it stands as a promising candidate to substitute the standard indium-tin-oxide (ITO) in applications. Its surface stability under water (both liquid and vapor) and other gaseous atmospheres is especially addressed. Through the use of spectroscopy characterizations, X-ray photoemission and operando X-ray absorption measurements, the formation of a thin Sr-rich V5+ layer located at the surface of the polycrystalline SrVO3 film with aging is observed, and for the first time how it can be removed from the surface by solvating in water atmosphere. The surface recovery is associated to an etching process, here spectroscopically characterized in operando conditions, allowing to follow the stoichiometric modification under reaction. Once exposed in oxygen atmosphere, the Sr-rich V5+ layer forms again. The findings improve the understanding of aging effects in perovskite oxides, allowing for the development of functionalized films in which it is possible to control or to avoid an insulating surface layer. This constitutes an important step towards the large-scale use of V-based TCOs, with possible implementations in oxide-based electronics. 相似文献