A new device for performing reference point indentation without a reference probe

Here we describe a novel, hand-held reference point indentation (RPI), instrument that is designed for clinical measurements of bone material properties in living patients. This instrument differs from previous RPI instruments in that it requires neither a reference probe nor removal of the periosteum that covers the bone, thus significantly simplifying its use in patient testing. After describing the instrument, we discuss five guidelines for optimal and reproducible results. These are: (1) the angle between the normal to the surface and the axis of the instrument should be less than 10°, (2) the compression of the main spring to trigger the device must be performed slowly (>1 s), (3) the probe tip should be sharper than 10 μm; however, a normalized parameter with a calibration phantom can correct for dull tips up to a 100 μm radius, (4) the ambient room temperature should be between 4?°C and 37 °C, and (5) the effective mass of the bone or material under test must exceed 1 kg, or if under 1 kg, the specimen should be securely anchored in a fixation device with sufficient mass (which is not a requirement of previous RPI instruments). Our experience is that a person can be trained with these guidelines in about 5 min and thereafter obtain accurate and reproducible results. The portability, ease of use, and minimal training make this instrument suitable to measure bone material properties in a clinical setting.     

Theoretical Correlations and Measured Correlations: Relating Recognition and Recall in Four Distributed Memory Models.

This article addresses the relation between item recognition and associative (cued) recall. Going beyond measures of performance on each task, the analysis focuses on the degree to which the contingency between successful recognition and successful recall of a studied item reflects the commonality of memory processes underlying the recognition and recall tasks. Specifically, 4 classes of distributed memory models are assessed for their ability to account for the relatively invariant correlation (≈ .5) between successive recognition and recall. Basic versions of each model either under- or overpredict the intertask correlation. Introducing variability in goodness-of-encoding and response criteria, as well as output encoding, enabled all 4 models to reproduce the moderate intertask correlation and the increase in correlation observed in 2 mixed-list experiments. This model-based analysis provides a general theoretical framework for interpreting contingencies between successive memory tests. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A new approach to adaptive control: no nonlinearities

In adaptive control the goal is to design a controller to control an uncertain system whose parameters may be changing with time. Typically the controller consists of an identifier (or tuner) which is used to adjust the parameters of a linear time-invariant (LTI) compensator, and under suitable assumptions on the plant model uncertainty it is proven that good asymptotic behaviour is achieved, such as model matching (for minimum phase systems) or stability. However, a typical adaptive controller does not track time-varying parameters very well, and it is often highly nonlinear, which can result in undesirable behaviour, such as large transients or a large control signal. Furthermore, most adaptive controllers provide only asymptotic tracking, with no ability to design for a pre-specified settling time.Here we propose an alternative approach, which yields a linear periodic controller. Rather than estimating the plant or compensator parameters, instead we estimate what the control signal would be if the plant parameters were known. In this paper we argue the utility of this approach and then examine the first order case in detail, including a simulation. We also explore the benefits and limitations of the approach.     

Coordination in networks: An economic equilibrium analysis

Networks utilizing modern communication technologies can offer competitive advantages to those using them wisely. But due to the existence of network effects, planning and operating cooperation networks is difficult. In this paper, the strategic situation of individual agents deciding on network participation is analysed. A systematic equilibrium analysis using computer-based simulations reveals principal solution scenarios for network agents and shows that network cooperation problems might frequently be not as difficult to resolve as often feared. In particular, strategic situations are identified showing that a majority of individuals might be better off getting the optimal solution from a central principal and that in many cases simple information intermediation can solve the start-up problem notorious in network economics.     

A Software Tool for Automatically Verified Operations on Intervals and Probability Distributions

We describe a software tool for performing automatically verified arithmetic operations on independent operands when the operands are intervals, or probability distribution functions, or one operand is an interval and the other is a distribution. Intervals and distributions are expressed using the same technique, so the algorithms do not need to distinguish between intervals and distributions in their operation. The tool can calculate common arithmetic operations with guaranteed results (as well as confidence limits on a distribution if the distribution is empirically estimated from samples).A previous paper [1] discusses the concepts, algorithms, and related work. Here we emphasize a software tool that implements the algorithms, interacts with the user via a graphical user interface, and saves, retrieves, and prints the results of its calculations.     

Simulation Study of Aspects of the Classical Hydrogen Atom Interacting with Electromagnetic Radiation: Elliptical Orbits

The present study examines the behavior of a classical charged point particle in near-elliptic orbits about an infinitely massive and oppositely charged nucleus, while acted upon by applied electromagnetic radiation. As recently shown for near-circular orbits, and now extended here to the elliptical case, rather surprising nonlinear dynamical effects are readily produced for this simple system. A broad range of stability-like conditions can be achieved by applying radiation to this classical atom. A perfect balance condition is examined, which requires an infinite number of plane waves representing harmonics of the orbital motion. By applying a scale factor to this radiation, stability-like conditions are produced where periodic variations in semimajor and semiminor axes occur for extended periods of time, before orbital decay eventually takes over due to the effects of radiation reaction. This work is expected to lead to both practical suggestions on experimental ideas involving controlling ionization and stabilization conditions, as well as hopefully aiding in theoretical explorations of stochastic electrodynamics.     

Specific Local Predictors That Reflect the Tropism of Endometriosis—A Multiple Immunohistochemistry Technique

Ectopic endometrial epithelium associates a wide spectrum of symptomatology. Their evolution can be influenced by inflammatory and vascular changes, that affect not only the structure and cell proliferation rate, but also symptoms. This prospective study involved tissue samples from surgically treated patients, stained using classical histotechniques and immunohistochemistry. We assessed ectopic endometrial glands (CK7+, CK20−), adjacent blood vessels (CD34+), estrogen/progesterone hormone receptors (ER+, PR+), inflammatory cells (CD3+, CD20+, CD68+, Tryptase+), rate of inflammatory cells (Ki67+) and oncoproteins (BCL2+, PTEN+, p53+) involved in the development of endometriosis/adenomyosis. A CK7+/CK20− expression profile was present in the ectopic epithelium and differentiated it from digestive metastases. ER+/PR+ were present in all cases analyzed. We found an increased vascularity (CD34+) in the areas with abdominal endometriosis and CD3+−:T-lymphocytes, CD20+−:B-lymphocytes, CD68+:macrophages, and Tryptase+: mastocytes were abundant, especially in cases with adenomyosis as a marker of proinflammatory microenvironment. In addition, we found a significantly higher division index-(Ki67+) in the areas with adenomyosis, and inactivation of tumor suppressor genes-p53+ in areas with neoplastic changes. The inflammatory/vascular/hormonal mechanisms trigger endometriosis progression and neoplastic changes increasing local pain. Furthermore, they may represent future therapeutic targets. Simultaneous-multiple immunohistochemical labelling represents a valuable technique for rapidly detecting cellular features that facilitate comparative analysis of the studied predictors.     

Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses

Smoking is a risk factor for a variety of deleterious conditions, such as cancer, respiratory disease and cardiovascular disease. Thrombosis is an important and common aspect of several cardiovascular disease states, whose risk is known to be increased by both first- and secondhand smoke. More recently, the residual cigarette smoke that persists after someone has smoked (referred to as thirdhand smoke or THS) has been gaining more attention, since it has been shown that it also negatively affects health. Indeed, we have previously shown that 6-month exposure to THS increases the risk of thrombogenesis. However, neither the time-dependence of THS-induced thrombus formation, nor its sex dependence have been investigated. Thus, in the present study, we investigated these issues in the context of a shorter exposure to THS, specifically 3 months, in male and female mice. We show that the platelets from 3-month THS-exposed mice exhibited enhanced activation by agonists. Moreover, we also show that mice of both sexes exposed to THS have decreased tail bleeding as well as decreased thrombus occlusion time. In terms of the role of sex, intersex disparities in thrombus development and hemostasis as well as in platelet aggregation were, interestingly, observed. Together, our findings show that exposing mice to THS for 3 months is sufficient to predispose them to thrombosis; which seems to be driven, at least in part, by an increased activity in platelets, and that it does not manifest equally in both sexes.