The “River Disease” (RD), a disorder impacting honeybee colonies located close to waterways with abundant riparian vegetation (including Sebastiania schottiana, Euphorbiaceae), kills newly hatched larvae. Forager bees from RD-affected colonies collect honeydew excretions from Epormenis cestri (Hemiptera: Flatidae), a planthopper feeding on trees of S. schottiana. First-instar honeybee larvae fed with this honeydew died. Thus, we postulated that the nectars of RD-affected colonies had a natural toxin coming from either E. cestri or S. schottiana. An untargeted metabolomics characterization of fresh nectars extracts from colonies with and without RD allowed to pinpoint xanthoxylin as one of the chemicals present in higher amounts in nectar from RD-affected colonies than in nectars from healthy colonies. Besides, xanthoxylin was also found in the aerial parts of S. schottiana and the honeydew excreted by E. cestri feeding on this tree. A larva feeding assay where xanthoxylin-enriched diets were offered to 1st instar larvae showed that larvae died in the same proportion as larvae did when offered enriched diets with nectars from RD-colonies. These findings demonstrate that a xenobiotic can mimic the RD syndrome in honeybee larvae and provide evidence of an interspecific flow of xanthoxylin among three trophic levels. Further, our results give information that can be considered when implementing measures to control this honeybee disease.
In many business applications, large data workloads such as sales figures or process performance measures need to be monitored in real‐time. The data analysts want to catch problems in flight to reveal the root cause of anomalies. Immediate actions need to be taken before the problems become too expensive or consume too many resources. In the meantime, analysts need to have the “big picture” of what the information is about. In this paper, we derive and analyze two real‐time visualization techniques for managing density displays: (1) circular overlay d isplays which visualize large volumes of data without data shift movements after the display is full, thus freeing the analyst from adjusting the mental picture of the data after each data shift; and (2) variable resolution density displays which allow users to get the entire view without cluttering. We evaluate these techniques with respect to a number of evaluation measures, such as constancy of the display and usage of display space, and compare them to conventional d isplays with periodic shifts. Our real time data monitoring system also provides advanced interactions such as a local root cause analysis for further exploration. The applications using a number of real‐world data sets show the wide applicability and usefulness of our ideas. 相似文献
In order to be capable of exploiting context for pro-active information recommendation, agents need to extract and understand
user activities based on their knowledge of the user interests. In this paper, we propose a novel approach for context-aware
recommendation in browsing assistants based on the integration of user profiles, navigational patterns and contextual elements.
In this approach, user profiles built using an unsupervised Web page clustering algorithm are used to characterize user ongoing
activities and behavior patterns. Experimental evidence show that using longer-term interests to explain active browsing goals
user assistance is effectively enhanced.
The possibility of using sub‐micrometer polymeric stomatocytes is investigated to effectuate confined crystallization of inorganic compounds. These bowl‐shaped polymeric compartments facilitate confined crystallization while their glassy surfaces provide their crystalline cargos with convenient shielding from the electron beam's harsh effects during transmission electron microscopy experiments. Stomatocytes host the growth of a single nanocrystal per nanocavity, and the electron diffraction experiments reveal that their glassy membranes do not interfere with the diffraction patterns obtained from their crystalline cargos. Therefore, it is expected that the encapsulation and crystallization within these compartments can be considered as a promising template (nanovials) that hold and protect nanocrystals and protein clusters from the direct radiation damage before data acquisition, while they are examined by modern crystallography methodologies such as serial femtosecond crystallography. 相似文献
The objective of this paper was solving the optimization problem of lightweight stiffened structures modelled as a two-dimensional
domain in an efficient computational way. The underlying premise was that mass should be distributed in an efficient way,
so as to use a minimum amount of material to accomplish the mechanical function. This premise was expressed as a global, multi-objective
optimization problem in which stiffness and mass were conflicting objectives. Alternative local evolution rules were implemented
to update mass density or Young’s modulus at each step of the iterative procedure. The solution of the structural optimization
problem was accomplished by a novel automatic procedure consisting of two consecutive stages of control and optimization.
In the first stage of Proportional Integral Derivative (PID) control gains were manually selected whereas in the second stage
the finding of optimal values of control gains, target, and cost indices was allowed. In this study a bone-like material was
adopted and a thin slab was analysed as a sample problem. 相似文献