Distributed Coordination and Workflow on the World Wide Web

This paper describes WebFlow, an environment thatsupports distributed coordination services on theWorld Wide Web. WebFlow leverages the HTTP Webtransport protocol and consists of a number of toolsfor the development of applications that require thecoordination of multiple, distributed servers.Typical applications of WebFlow include distributeddocument workspaces, inter/intra-enterprise workflow,and electronic commerce. In this paper we describe thegeneral WebFlow architecture for distributedcoordination, and then focus on the environment fordistributed workflow.     

Nondegradative microextrusion of resorbable polyesters for pharmaceutical and biomedical applications: The cases of poly‐lactic‐acid and poly‐caprolactone

In recent years biodegradable polymers, particularly polyesters such as the poly(lactic acid) (PLA) and polycaprolactone (PCL), have gained high interests for their applicability in the biomedical and pharmaceutical fields where they're used for manufacturing various different resorbable devices, from tissue engineering scaffolds to controlled drug release systems. Despite many positive characteristics, processability of these materials still remains a critical issue as they easily tend to degrade during manufacturing. In this article we aimed to assess microextrusion as a nondegradative process for manufacturing PLA and PCL. The results we experimentally obtained, that are hereby presented, set a new point in the on‐going debate on degradation during processing of resorbable polymers as they allow to affirm that microextrusion leaves unmodified molecular weight distributions without producing any evident reductions in mean molecular weight. Microextrusion thus represents a risk‐free high molecular weight polymer processing solution for obtaining nondegraded products within pharmaceutical and biomedical production lines, such as for scaffolds for tissue engineering applications or drug delivery. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Treatment of aggression for an adult diagnosed with schizophrenia at a public psychiatric hospital.

The effectiveness of a behavioral program to treat chronic aggression in an adult male individual diagnosed with schizophrenia at a public psychiatric hospital was evaluated. A behavioral plan was developed to provide the client with positive social interactions, social skills training, and positive reinforcement for prosocial behavior; no negative consequences were implemented. The number of aggressive acts declined with the introduction of the behavioral plan and ultimately remitted even without ongoing reinforcers. This article demonstrates the value of psychological intervention in treating aggression with a treatment-resistant client in an in-patient setting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Convective cooling of supercritical carbon dioxide inside tubes: heat transfer analysis through neural networks

In a previous work, convective heating of carbon dioxide was studied with neural networks (NN), obtaining a totally heuristical heat transfer equation from the direct regression of experimental data. In the present work, the analysis focuses on the cooling process, which has a technical relevance in various applications, as for example in transcritical refrigeration cycles. Heat transfer around the critical zone presents a marked enhancement, that follows the peaks in thermophysical properties like thermal conductivity and heat capacity. Similarly, other properties like density and enthalpy, present a strong variation in narrow temperature intervals around the critical point.This constitutes then a highly non-linear phenomenon, for which it is advisable to use a very flexible function approximator like the NNs. NN models were applied both in terms of dimensionless numbers and of physical quantities, obtaining the two corresponding NN architectures. The choice of the optimal number of neurons in the NN hidden layer is discussed. The NN models are then compared with a recent correlation from literature, for which the validation results present an AAD of 27% and a bias of −26% with an evident prediction shifting. On the other hand the NN models in terms of dimensionless numbers and of physical quantities have AAD and bias of 14% and −4%, and of 7% and −2%, respectively, showing a largely better performance.     

Modulation of the enzymatic activity of papain by interdomain residues remote from the active site

The two main catalytic residues Cys25 and Hisl59 of the monomericcysteine protease papain are located on different walls of acleft formed by two domains. This topology suggests a possiblerelationship between relative domain organization and catalyticmechanism. The effect on enzymatic parameters of structuralmodifications at various locations of the twodomain interfaceof papain was examined by individual or double replacementsby Ala of pairs of interacting residues. Most modificationshad no effect on enzyme activity. However, the enzyme's substrateturnover (k_cat) decreased following simultaneous alterationof the two most conserved residues, forming an apolar contactlocated 15 Å away from the active site. The pH activityprofile of the double mutant was unchanged, indicating a conservedionization state of the active site thiolate-imidazolium ionpair. This state is strongly dependent on the distance separatingthe two residues, thus suggesting that the active site geometryhas not been significantly altered. Efficient enzymatic activityin papain requires more than a correct active site geometryand is influenced by domain packing properties in a region remotefrom the active site.     

A Web‐based Open‐source Geoinformation Tool for Regional Water Resources Assessment

Water Resources Management - To reduce the impact of droughts and increase the resilience of regional water systems, various competing demands, such as hydropower, supply, irrigation and river...     

BRAF Gene and Melanoma: Back to the Future

As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients.     

A novel technique for the preparation of secondary fatty amides

A technique for the synthesis of monosubstituted fatty amides at low temperature and ambient pressure was developed. This method involved the condensation of an amine with a triacylglycerol. The primary amine (ethyl,n-butyl,n-hexyl andn-octyl were tested) acted as reagent and solvent for the fatty substrates. No additional organic solvent or catalyst was added. Tallow, vegetable oils and fish oil all served well as substrates, as did pure tripalmitin. The rate of amidation was dependent upon temperature and the ratio of fat to amine. In a series of experiments conducted with tallow andn-butylamine at a fat:amine molar ratio of 1:16, amidation could be carried out at 20°C, producingn-butyltallowamide in 83% yield in 24 hr. When the fat:amine molar ratio was reduced to 1:8, and the temperature raised to 45°C, the amide yield was 87.6% in 24 hr. When the reaction was carried out at the boiling point ofn-butylamine (78°C) and at a fat:amine ratio of 1:8, the amide yield was 93.2% in 4 hr. The reaction progressed more rapidly with higher molecular weight amines. The identity and purity of the amides was assessed by thin-layer chromatography and confirmed by elemental analyses and infrared and C¹³ nuclear magnetic resonance spectroscopy.     

Elastomeric properties of ethylene/propylene copolymers prepared by zirconocene/methylaluminoxane catalysts

Ethylene/propylene copolymers (EPM) have been prepared by a liquid propylene suspension process, using homogeneous catalysts based on nonbridged zirconocenes and methylaluminoxane (MAO). When bis(η⁵-cyclopentadienyl)zirconium dichloride (Cp₂ZrCl₂), bis(η⁵-cyclopentadienyl) dimethyl zirconium (Cp₂ZrMe₂) and bis(η⁵-cyclopentadienyl), dibenzyl zirconium (Cp₂ZrBz₂) were used as catalyst components, EPM having low average molecular weight (MW) were in general obtained in low yield. On the contrary, a very large improvement of productivity and MW was observed when bis(η⁵-indenyl)zirconium dichloride (Ind₂ZrCl₂) and bis(η⁵-indenyl) dimethyl zirconium (Ind₂ZrMe₂) as well as bis(η⁵-tetrahydroindenyl)zirconium dichloride [(IndH₄)₂ZrCI₂] were employed in combination with MAO. In particular, this last catalytic system allowed one to obtain EPM with a narrower distribution of MW in addition to the above characteristics. Better performances, in terms of rheological and elastomeric properties, were also found for the crude and vulcanized samples prepared by (IndH₄)₂ZrCl₂/MAO catalyst.