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排序方式: 共有1247条查询结果,搜索用时 15 毫秒
31.
Luca Mignani Daniela Zizioli Deepak Khatri Nicola Facchinello Marco Schiavone Giuseppe De Palma Dario Finazzi 《International journal of molecular sciences》2022,23(21)
Coenzyme A (CoA) is an essential cofactor in all living organisms, being involved in a large number of chemical reactions. Sequence variations in pantothenate kinase 2 (PANK2), the first enzyme of CoA biosynthesis, are found in patients affected by Pantothenate Kinase Associated Neurodegeneration (PKAN), one of the most common forms of neurodegeneration, with brain iron accumulation. Knowledge about the biochemical and molecular features of this disorder has increased a lot in recent years. Nonetheless, the main culprit of the pathology is not well defined, and no treatment option is available yet. In order to contribute to the understanding of this disease and facilitate the search for therapies, we explored the potential of the zebrafish animal model and generated lines carrying biallelic mutations in the pank2 gene. The phenotypic characterization of pank2-mutant embryos revealed anomalies in the development of venous vascular structures and germ cells. Adult fish showed testicular atrophy and altered behavioral response in an anxiety test but no evident signs of neurodegeneration. The study suggests that selected cell and tissue types show a higher vulnerability to pank2 deficiency in zebrafish. Deciphering the biological basis of this phenomenon could provide relevant clues for better understanding and treating PKAN. 相似文献
32.
Chiara Sanguinetti Valentina Scalise Tommaso Neri Alessandro Celi Vanessa Susini Maria Franzini Roberto Pedrinelli 《International journal of molecular sciences》2022,23(20)
Gamma-glutamyl transferase (GGT) is involved in the progression of atherosclerosis, since its enzymatic activity promotes the generation of reactive oxygen species (ROS). Besides, GGT may act as a prothrombotic factor by inducing tissue factor (TF) expression, independently of its enzymatic activity. The aim of this study was to assess whether GGT-induced TF stimulation was a consequence of binding to toll-like receptor 4 (TLR4) expressed on monocytes, the precursors of macrophages and foam cells which colocalize with GGT activity within atherosclerotic plaques. Experiments were performed in human peripheral blood mononuclear cells (PBMCs), THP-1 cells (a monocytic cellular model), and HEK293 cells, which were genetically modified to study the activation of TLR4. TF procoagulant activity was assessed by a one-stage clotting time test, and TF protein expression was estimated by western blot. Human recombinant (hr) GGT protein increased TF procoagulant activity and protein expression in both PBMCs and THP-1 cells. The GGT-induced TF stimulation was prevented by cellular pretreatment with TLR4/NF-κB inhibitors (LPS-Rs, CLI-095, and BAY-11-7082), and HEK293 cells lacking TLR4 confirmed that TLR4 is essential for GGT-induced activation of NF-κB. In conclusion, hrGGT induced TF expression in monocytes through a cytokine-like mechanism that involved the activation of TLR4/NF-κB signaling. 相似文献
33.
Influence of olive ripening degree and crusher typology on chemical and sensory characteristics of Correggiolo virgin olive oil 下载免费PDF全文
34.
Kieran Jordan Marion Dalmasso Juergen Zentek Anneluise Mader Geert Bruggeman John Wallace Dario De Medici Alfonsina Fiore Estella Prukner‐Radovcic Maja Lukac Lars Axelsson Askild Holck Hanne Ingmer Mindaugas Malakauskas 《Journal of the science of food and agriculture》2014,94(15):3079-3089
Foodborne illness continues as a considerable threat to public health. Despite improved hygiene management systems and increased regulation, pathogenic bacteria still contaminate food, causing sporadic cases of illness and disease outbreaks worldwide. For many centuries, microbial antagonism has been used in food processing to improve food safety. An understanding of the mode of action of this microbial antagonism has been gained in recent years and potential applications in food and feed safety are now being explored. This review focuses on the potential opportunities presented, and the limitations, of using microbial antagonism as a biocontrol mechanism to reduce contamination along the food chain; including animal feed as its first link. © 2014 Society of Chemical Industry 相似文献
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Dario Imbraguglio Andrea Mario Giovannozzi Annalisa Nastro Andrea Mario Rossi 《Nanoscale research letters》2012,7(1):530
Three-dimensional submicrometric structures and biomolecular patterns have been fabricated on a porous silicon film by an electron beam-based functionalization method. The immobilized proteins act as a passivation layer against material corrosion in aqueous solutions. The effects'' dependence on the main parameters of the process (i.e., the electron beam dose, the biomolecule concentration, and the incubation time) has been demonstrated. 相似文献
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In literature, a large number of studies on the Italian districts exhibit a portrait which points out the Italian economic specificity. A specific feature of the Italian districts is the large number of collaborative actions carried on by the associated enterprises which are not limited to the solution of the usual supply chain management problems. As not all the collaborative actions bring immediate (and measurable) economic benefits, there is the need for a reliable and unbiased method aimed at the identification and analysis of the collaborative patterns inside an industry network, to determine their presence and effectiveness. The proposed method uses a graph representation of the inter-firm relationships inside a network and induces the presence of collaborative behaviours by the analysis of the graph topology. 相似文献
39.
Kim Christensen Dario Papavassiliou Alexandre de Figueiredo Nigel R. Franks Ana B. Sendova-Franks 《Journal of the Royal Society Interface》2015,12(102)
Prediction for social systems is a major challenge. Universality at the social level has inspired a unified theory for urban living but individual variation makes predicting relationships within societies difficult. Here, we show that in ant societies individual average speed is higher when event duration is longer. Expressed as a single scaling function, this relationship is universal because for any event duration an ant, on average, moves at the corresponding average speed except for a short acceleration and deceleration at the beginning and end. This establishes cause and effect within a social system and may inform engineering and control of artificial ones. 相似文献
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