Humans: the missing link in manufacturing simulation?

Computer based discrete event simulation (DES) is one of the most commonly used aids for the design of automotive manufacturing systems. However, DES tools represent machines in extensive detail, while only representing workers as simple resources. This presents a problem when modelling systems with a highly manual work content, such as an assembly line. This paper describes research at Cranfield University, in collaboration with the Ford Motor Company, founded on the assumption that human variation is the cause of a large percentage of the disparity between simulation predictions and real world performance. The research aims to improve the accuracy and reliability of simulation prediction by including models of human factors.     

Temperamental resistance to control increases the association between sleep problems and externalizing behavior development.

This study examined the moderating effects of temperamental resistance to control on the link between development of sleep problems and development of externalizing behaviors over a 5-year period. Resistance to control was assessed with mothers' retrospective reports of temperament in infancy, provided when children were 5 years of age. Sleep problems were assessed with mother reports on an annual basis from age 5 to age 9. Externalizing behaviors were assessed with teacher reports on an annual basis from age 5 to age 9. A cross-domain latent growth curve model indicated that sleep problem trajectories were positively associated with externalizing behavior trajectories only for children high in resistance to control. In addition, resistance to control was positively associated with initial (age 5) sleep problems and initial (age 5) externalizing behaviors. The authors speculate that the development of sleep problems promotes the development of behavior problems for resistant children, whose self-regulatory abilities are especially tenuous. Implications for prevention and treatment of conduct problems are considered. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A semiautomated electron backscatter diffraction technique for extracting reliable twin statistics

A framework has been developed for extracting reliable twin statistics from a deformed microstructure using crystallographic twin identification techniques with spatially correlated electron backscatter diffraction (EBSD) data. The key features of this analysis are the use of the mathematical definition of twin relationships, the inclination of the common K ₁ plane at a twin boundary, and the correct identification of the parent orientation in a parent/twin pair. Methods for identifying the parent in a parent/twin pair will be briefly discussed and compared. Twin area fractions are then categorized by operative twin systems, number of active twin variants in each system, and corrected twin widths. These statistics are reported here for α-zirconium samples deformed in quasi-static four-point bend beams and in a 100 m/s Taylor cylinder impact test. Analysis of the statistics also begins to reveal the roles that deformation rate and relative orientation of the boundary conditions to the material’s symmetry axes play in determining the twinning activity that accommodates the imposed boundary conditions. These improved twin statistics can help quantify the deformation processes in materials that deform by twinning as well as serve to provide better validation of proposed models of the deformation processes.     

The Joint Evaluation Procedure for Active Substances contained in Plant Protection Products within the European Community – 10?Years of the ECCO-Project

Pflanzenschutzmittel müssen seit 1993 in den Mitgliedstaaten der Europ?ischen Gemeinschaft nach der Richtlinie 91/414/EWG des Rates bewertet und zugelassen werden. Das Programm zur Bewertung von alten Wirkstoffen (welche vor Juli 1993 auf dem Markt waren) beinhaltet mehrere Schritte und Stufen, die früher über einen Zeitraum von bis zu 10 Jahren zu bew?ltigen waren; heute sind dafür jedoch 15 Jahre vorgesehen. Das Programm wurde seit 1996 von der Europ?ischen Kommission mit Unterstützung des ECCO-Teams(European Community Co-Ordination) koordiniert. Das ECCO-Team bestand aus zwei Gruppen: eine im Pesticides Safety Directorate – PSD in York (Gro?britannien) und eine im Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) bzw. vor November 2002 in der Biologischen Bundesanstalt für Land- und Forstwirtschaft in Braunschweig. Sie unterstüzten das Programm zur Bewertung von Wirkstoffen im Namen der Kommission in technischer und administrativer Hinsicht und zeichneten sich insbesondere für das ECCO Peer Review Programm (Expertenprüfungen) verantwortlich. Im November 2003 übernahm die Europ?ische Beh?rde für Lebensmittelsicherheit (EFSA) die Verantwortung für die wissenschaftliche überprüfung der von den Mitgliedstaaten erstellten Bewertungen durch Experten. Das ECCO-Team leistete jedoch weiterhin der Europ?ischen Kommission Unterstützung bei der Durchführung anderer Verfahrensaspekte, vor allem im Bereich der Managementaufgaben der Europ?ischen Kommission. Insgesamt war das Programm au?erordentlich erfolgreich. Es wurden für 162 Wirkstoffen zwischen 1996 und 2003 der Inhalt der von den Mitgliedstaaten erstellten Bewertungsberichte durch eine Expertengruppe diskutiert und füberprüft, was ma?geblich eine Entscheidungsfindung zur Akzeptabilitf?t dieser Wirkstoffe auf Gemeinschaftsebene erm?glicht hat.     

On Linear Copositive Lyapunov Functions and the Stability of Switched Positive Linear Systems

We consider the problem of common linear copositive Lyapunov function existence for positive switched linear systems. In particular, we present a necessary and sufficient condition for the existence of such a function for switched systems with two constituent linear time-invariant systems. Several applications of this result are also given.     

Biophysical Model of Larval Yellow Perch Advection and Settlement in Lake Michigan

Potential for large-scale physical transport processes to affect recruitment of Lake Michigan yellow perch (Perca flavescens) was studied by examining the variation in larval distribution, growth rate, and settlement during June–August 1998–2003 using a 3D particle transport model linked with an individual-based bioenergetics growth model. In all years, virtual larvae were released nearshore in southwestern Lake Michigan, a known and important spawning region for yellow perch. For any given year, the same circulation pattern and water temperature either promoted or reduced yellow perch settlement depending on the consumption rates and settlement size chosen in the growth model. Increased consumption increased the number of settled larvae and expanded the total area where larvae settled, whereas increased settlement size reduced the number of settled larvae and reduced the overall settlement area. Interannual variability in circulation patterns and water temperature also resulted in contrasting larval settlement rates, settlement locations, and size of settlement areas between years. Model predictions were most consistent with field observations of age-0 yellow perch from Illinois and Michigan waters when settlement was assumed to occur at 50 mm. Moreover, our model suggests that larvae originating from southwestern Lake Michigan can recruit anywhere within the southern basin and even in the northern basin. Future model improvement will require information on the relative contribution of various sectors to the larval pool, their distribution with reference to the hydrodynamic landscape, the feeding and growth of yellow perch during their pelagic phase, and the size at transition to demersal stage.     

Gene expression in brain during cuprizone-induced demyelination and remyelination

When C57BL/6J mice, 8 weeks of age, received 0.2% Cuprizone in their diet, extensive demyelination in corpus callosum was detectable after 3 weeks, and there was massive demyelination by 4 weeks. As expected, the accumulation of phagocytically active microglia/macrophages correlated closely with demyelination. When Cuprizone was removed from the diet, remyelination was soon initiated; after 6 weeks of recovery, myelin levels were near-normal and phagocytic cells were no longer prominent. Steady-state levels of mRNA for myelin-associated glycoprotein, myelin basic protein, and ceramide galactosyltransferase were already profoundly depressed after 1 week of Cuprizone exposure and were only 10-20% of control values after 2 weeks. Unexpectedly, upregulation of mRNA for these myelin genes did not correlate with initiation of remyelination but rather with accumulation of microglia/macrophages. After 6 weeks of exposure to Cuprizone, mRNA levels were at control levels or higher-in the face of massive demyelination. This suggests that in addition to effecting myelin removal, microglia/macrophages may simultaneously push surviving oligodendroglia or their progenitors toward myelination.