Réalité actuelle des couples homosexuels: Implications cliniques en contexte de thérapie conjugale.

Despite the fact that a large number of homosexual couples seek professional help when confronted with marital difficulties, relatively little knowledge is available to psychologists working with these clients. Although gay and lesbian couples greatly resemble heterosexual couples on most of the conjugal dimensions, it seems that same sex couples do have a unique reality to their sexual orientation. The present article constitutes an innovative synthesis of the actual knowledge concerning therapeutic intervention with gay and lesbian couples. First, the specific motives for these couples to seek help are discussed (i.e., issues related to homophobia, the lack of conjugal models, the "coming out" process, and the influence of socialization). Then, changes relating to issues relevant to some same sex couples brought to theoretical frameworks in psychology are explored. The frameworks that we examine are psychoanalytic, adlerian and cognitive behavioural. Finally, issues associated with HIV are discussed given its importance for die homosexual population and its impact on gay couples. This article, far from wanting to stigmatize even more homosexual couples, aims to support psychologists in their reflection and search for adequate interventions with this population that still... (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Preoperative radiotherapy and surgery for endometrial carcinoma: prognostic significance of the sterilization of the specimen

We have recently demonstrated that two different forms of IL-4R exist; classical or alternative. The classical IL-4R is predominantly expressed in hematopoietic cells and consist of IL-4R and IL-2Rgammac (gammac) chains. On the other hand, alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha' chains. Moreover, the alternative form of IL-4R is also utilized as a functional component IL-13R complex. It has been shown that the phosphorylation and activation of JAK3 tyrosine kinase is crucial for IL-4 activation of STAT6 in hematopoietic cells. However, we have recently demonstrated that non-hematopoietic cells lack JAK3 expression. We also demonstrated that in these cells, STAT6 activation is mediated through JAK1 and JAK2 tyrosine kinases instead. Furthermore, our results show that IL-4 and IL-13 signals are transmitted through the alternative form of IL-4R in these cells. Thus, major differences exist between hematopoietic and non-hematopoietic cells with regard to structure and signal transduction through IL-4R and IL-13R systems.     

Social comparison, self-stereotyping, and gender differences in self-construals.

Four studies examined gender differences in self-construals and the role of social comparison in generating these differences. Consistent with previous research, Study 1 (N=461) showed that women define themselves as higher in relational interdependence than men, and men define themselves as higher in independence/agency than women. Study 2 (N=301) showed that within-gender social comparison decreases gender differences in self-construals relative to a control condition, whereas between-genders comparison increases gender differences on both relational interdependence and independence/agency. Studies 3 (N=169) and 4 (N=278) confirmed these findings and showed that changing self-construal changes gender differences in social dominance orientation. Across the 4 studies, strong evidence for the role of in-group stereotyping as mediator of the effect of gender on self-construal was observed on the relational dimension but not on the agentic dimension. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stochastic nonlinear image restoration using the wavelet transform

The dominant methodology for image restoration is to stabilize the problem by including a roughness penalty in addition to faithfulness to the data. Among various choices, concave stabilizers stand out for their boundary detection capabilities, but the resulting cost function to be minimized is generally multimodal. Although simulated annealing is theoretically optimal to take up this challenge, standard stochastic algorithms suffer from two drawbacks: i) practical convergence difficulties are encountered with second-order prior models and ii) it remains computationally demanding to favor the formation of smooth contour lines by taking the discontinuity field explicitly into account. This work shows that both weaknesses can be overcome in a multiresolution framework by means of the 2-D discrete wavelet transform (DWT). We first propose to improve convergence toward global minima by single-site updating on the wavelet domain. For this purpose, a new restricted DWT space is introduced and a theoretically sound updating mechanism is constructed on this subspace. Next, we suggest to incorporate the smoothness of the discontinuity field via an additional penalty term defined on the high frequency subbands. The resulting increase in complexity is small and the approach requires the specification of a unique extra parameter for which an explicit selection formula is derived.     

Gastropod communities, vegetation dynamics and landscape changes along an old-field succession in Provence, France

Studies about the relationships between land snail communities and landscape are scarce. The abandonment of many cultivated lands in Provence since the end of the last century gives us the opportunity of an analysis of the organisation pattern of gastropod communities in relation to the recent history and the present day structure of a Mediterranean landscape. The dynamics of a 40 ha landscape, mapped on a raster mode, was studied using cadaster data for seven periods between 1890 and 1990. These data were computed using MCA and PCA. Both floristic and malacological relevés were made at a scale of one grid cell. At the stand level, the patterns of gastropod communities are strongly correlated with the vegetation structure and composition. At the landscape level, the analysis of gastropod communities permits a very good perception of the present day landscape structure, as well as insight into the recent landscape history. However, even if the fits obtained are good, they should be improved in order to take into account scale dependences of snail communities.     

Plasmodium telomeric sequences: structure, stability and quadruplex targeting by small compounds

The increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of the parasite could constitute an attractive target. They are composed of repetitions of a degenerate motif ((5')GGGTTYA(3'), where Y is T or C), different from the human one ((5')GGGTTA(3')). In this report we investigate the possibility of targeting Plasmodium telomeres with G-quadruplex ligands. Through solution hybridisation assays we provide evidence of the existence of a telomeric 3' G-overhang in P. falciparum genomic DNA. Through UV spectroscopy studies we demonstrate that stable G-quadruplex structures are formed at physiological temperature by sequences composed of the degenerate Plasmodium telomeric motif. Through a FRET melting assay we show stabilisation of Plasmodium telomeric G-quadruplexes by a variety of ligands. Many of the tested ligands display strong quadruplex versus duplex selectivity, but show little discrimination between human and Plasmodium telomeric quadruplexes.     

Biological Functions and Metabolism of Oleoylethanolamide

The present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-alpha) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-alpha. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid beta-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-alpha and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally.