The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system, devoted to drain away waste metabolic products and soluble proteins such as amyloid-beta. An impaired brain glymphatic system can increase the incidence of neurovascular, neuroinflammatory, and neurodegenerative diseases. Photobiomodulation (PBM) therapy can serve as a non-invasive neuroprotective strategy for maintaining and optimizing effective brain waste clearance. In this review, we discuss the crucial role of the glymphatic drainage system in removing toxins and waste metabolites from the brain. We review recent animal research on the neurotherapeutic benefits of PBM therapy on glymphatic drainage and clearance. We also highlight cellular mechanisms of PBM on the cerebral glymphatic system. Animal research has shed light on the beneficial effects of PBM on the cerebral drainage system through the clearance of amyloid-beta via meningeal lymphatic vessels. Finally, PBM-mediated increase in the blood–brain barrier permeability with a subsequent rise in Aβ clearance from PBM-induced relaxation of lymphatic vessels via a vasodilation process will be discussed. We conclude that PBM promotion of cranial and extracranial lymphatic system function might be a promising strategy for the treatment of brain diseases associated with cerebrospinal fluid outflow abnormality. 相似文献
One dimensional (1D) nanostructures attract considerable attention, enabling a broad application owing to their unique properties. However, the precise mechanism of 1D morphology attainment remains a matter of debate. In this study, ultrafast picosecond (ps) laser-induced treatment on upconversion nanoparticles (UCNPs) is offered as a tool for 1D-nanostructures formation. Fragmentation, reshaping through recrystallization process and bioadaptation of initially hydrophobic (β-Na1.5Y1.5F6: Yb3+, Tm3+/β-Na1.5Y1.5F6) core/shell nanoparticles by means of one-step laser treatment in water are demonstrated. “True” 1D nanostructures through “Medusa”-like structures can be obtained, maintaining anti-Stokes luminescence functionalities. A matter of the one-dimensional UCNPs based on direction of energy migration processes is debated. The proposed laser treatment approach is suitable for fast UCNP surface modification and nano-to-nano transformation, that open unique opportunities to expand UCNP applications in industry and biomedicine.
The influence of temperature and hardness level on the cyclic behavior of 55NiCrMoV7 steel, and the microstructure variation and hardness diminution during low cycle fatigue behavior were investigated. By means of SEM and XRD, the modality of carbides and the full width half maximum (FWHM) of martensite (211) [M(211)] of X ray diffraction spectrum in fatigue specimen were studied. The results showed that the cyclic stress response behavior generally showed an initial exponential softening for the first few cycles, followed by a gradual softening without cyclic softening saturation. The fatigue behavior of the steel is closely related to the hardness level. The hardness diminution and the variation of half width M(211) are remarkably influenced by the interaction between the cyclic plastic deformation and the thermal loading when the fatigue temperature exceeds the tempering temperature of the steel. 相似文献
Lubricant films containing colloidal overbased calcium salts have particular effects on detergency and on the wear process. The mechanical properties of such boundary films are very dependent on the process conditions, and are essentially a result of physico-chemical transformations of the colloid. Three types of films were compared: a film obtained by the drying of the base solvent, a film due to the compaction of the colloid between two steel surfaces, and a friction film obtained with this type of lubricant. Adsorption, compaction, and shear transformations induce a solid film. The pressure effect on the frictional behaviour of these colloidal films has been investigated using a surface force apparatus for low contact pressure (104 to 106 Pa), and using tribometers supporting heavy loads for the analysis of the high pressure domain. Above a critical pressure, evaluated at 106 Pa, the colloidal film does not flow, but forms a compacted mattress sliding on the surface plane and squeezing a molecular layer of lubricant. 相似文献
In this paper, a model based on a population balance equation (PBE) is developed. It aims at reproducing experimental floc size distributions obtained at steady state in a jar-test. The objective is to develop a simple model, based on physical phenomena, and that does not contain any adjustable parameters. Floc size distributions obtained using a part of a particle image velocimetry (PIV) device and image analysis are used to develop mathematical expressions for the aggregation and breakage kernels. A critical volume beyond which breakage is of significant importance is identified and related to the hydrodynamics. Hydrodynamic sequencing allows the distribution of the daughter particles resulting from a breakage event to be established. The model is finally successfully validated against experimental results. 相似文献
Concentration effects in the base-catalyzed hydrolysis of water-soluble methacrylates (3-(N,N-dimethylaminoethyl) methacrylate (DMAEMA), 2-hydroxyethyl methacrylate (HEMA) and oligo(ethylene glycol) methacrylates (OEGMAs)) have been studied. These monomers are rapidly hydrolyzed in the presence of bases at the room temperature in dilute aqueous solutions, but the reaction rate decreases sharply in highly concentrated solutions. A clear correlation was found between a form of the viscosity isotherm for DMAEMA solutions and the concentration dependence of the autocatalytic hydrolysis rate which indicates the connection of process kinetics with the structure of solutions. These data should be considered when carrying out homo- and copolymerization of the previously mentioned monomers in aqueous solutions. 相似文献
Monolithic sol–gel silica composites incorporating platinum‐based chromophores and various types of gold nanoparticles (AuNPs) are prepared and polished to high optical quality. Their photophysical properties are investigated. The glass materials show well‐defined localized surface plasmon resonance (SPR) absorbance from the visible to NIR. No redshifts of the AuNP plasmon absorption peaks due to the increase in nanoparticle doping concentration are observed in the glasses, proving that no or very small SPR coupling effects occur between the AuNPs. At 600 nm excitation, but not at 532 nm, the AuNPs improve the nonlinear absorption performance of glasses codoped with 50 × 10?3 m of a Pt‐acetylide chromophore. The glasses doped with lower concentrations of AuNPs (2–5 μm average distance) and 50 × 10?3 m in chromophore, show a marked improvement in nonlinear absorption, with no or only small improvement for the more highly AuNP doped glasses. This study shows the importance of excitation wavelength and nanoparticle concentration for composite systems employing AuNPs to improve two‐photon absorption of chromophores. 相似文献
Staphylococcus epidermidis is a bacterium that is part of the human microbiota. It is most abundant on the skin, in the respiratory system and in the human digestive tract. Also, Staphylococcus aureus contributes to human infections and has a high mortality rate. Both of these bacterial species produce biofilm, a pathogenic factor increasing their resistance to antibiotics. For this reason, we are looking for new substances that can neutralize bacterial cells. One of the best-known substances with such effects are silver nanoparticles. They exhibited antibacterial and antibiofilm formation activity that depended on their size, shape and the concentration used. In this review, we presented the data related to the use of silver nanoparticles in counteracting bacterial growth and biofilm formation published in scientific papers between 2017 and 2021. Based on the review of experimental results, the properties of nanoparticles prompt the expansion of research on their activity. 相似文献