Acts of will?

Discusses the articles contained in the present volume addressing the issue of will and the frequent disconnect between what people intend to do and what they actually do. The authors in the series suggest that people perceive themselves to have more control over everyday behavior than they actually do. The authors present a conceptual and empirical framework for understanding the causes of behavior for the times when it is recognized that "will" has broken down and people are unable to act as they desire. According to the authors, the source of behavioral control comes not from active awareness but from subtle cues in the environment and from thought processes and information not readily accessible to consciousness. The theory and data presented in these articles represent recent fundamental breakthroughs in the understanding of motivations, free will and behavioral control. The premise of the 4 articles is this: There are mental activations of which we are unaware and environmental cues to which we are not consciously attending that have a profound effect on our behavior and that help explain the complex puzzle of human motivation and actions that are seemingly inexplicable, even to the individual performing the actions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

L'attachment à l'age scolaire et le développement des troubles de comportement.

The purpose of this longitudinal study was to examine the association between the mother–child attachment relationship and behavioural problems among a test group of 120 Francophone Canadian children from mixed social and economic backgrounds. The Strange Situation protocol was used to measure attachment styles when the children were between the ages of 5 and 7 yrs. Each child's behavioural difficulties were assessed by his or her educator or teacher during 3 developmental periods: 3–5 yrs, 5–7 yrs, and 7–9 yrs. Results show that disorganized insecure attachment is associated with an increased risk of developing exteriorized and interiorized behavioural troubles between the ages of 5 and 7. The authors also observed exteriorized behavioural problems among children with anxious-ambivalent attachment, especially in the 3–5 age group. Avoidant children, usually assessed positively, received exteriorization scores during the 5–7 period which were significantly below those of securely attached children. Avoidant boys also exhibited more interiorized symptoms during this time-frame. Analyses of the persistence of behavioural problems also showed increased risk among disorganized and ambivalent children with secure or avoidant attachment styles. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury

Platelets, cellular mediators of thrombosis, are activated during sepsis and are increasingly recognized as mediators of the immune response. Platelet activation is significantly increased in sepsis patients compared to ICU control patients. Despite this correlation, the role of activated platelets in contributing to sepsis pathophysiology remains unclear. We previously demonstrated NOD-like receptor protein 3 inflammasome (NLRP3) inflammasome activation in sepsis-induced platelets from cecal-ligation puncture (CLP) rats. Activated platelets were associated with increased pulmonary edema and glomerular injury in CLP vs. SHAM controls. In this study, we investigated whether inhibition of platelet activation would attenuate NLRP3 activation and renal and pulmonary injury in response to CLP. CLP was performed in male and female Sprague Dawley (SD) rats (n = 10/group) to induce abdominal sepsis and SHAM rats served as controls. A subset of CLP animals was treated with Clopidogrel (10 mg/kg/day, CLP + CLOP) to inhibit platelet activation. At 72 h post-CLP, platelet activation and NLRP3 inflammasome assembly were evaluated, IL-1β and IL-18 were measured in plasma, and tissues, renal and pulmonary pathology, and renal function were assessed. Activated platelets were 7.8 ± 3.6% in Sham, 22 ± 6% in CLP and significantly decreased to 14.5 ± 0.6% in CLP + CLOP (n = 8–10/group, p < 0.05). NLRP3 inflammasome assembly was inhibited in platelets of CLP + CLOP animals vs. CLP. Significant increases in plasma and kidney IL-1β and IL-18 in response to CLP were decreased with Clopidogrel treatment. Renal injury, but not lung histology or renal function was improved in CLP + CLOP vs. CLP. These data provide evidence that activated platelets may contribute to sepsis-induced renal injury, possibly via NLRP3 activation in platelets. Platelets may be a therapeutic target to decrease renal injury in septic patients.     

Role of Detoxification of Plant Secondary Compounds on Diet Breadth in a Mammalian Herbivore, Trichosurus vulpecula

Theory predicts that mammalian herbivores detoxify different classes of plant secondary compounds via separate metabolic pathways and that generalist herbivores maintain broad diet breadth to avoid overloading individual detoxification pathways. We tested the hypothesis that a generalist marsupial herbivore, the common brushtail possum, Trichosurus vulpecula, can maintain a higher intake of food when allowed to select from two diets containing different profiles of secondary compounds (phenolics and terpenes) than when given access to the diets individually. Diets consisted of a fruit and vegetable mash to which was added ground leaves of either Eucalyptus melliodora or E. radiata. E. melliodora and E. radiata differ in their concentrations and types of secondary compounds. Brushtail possums include these eucalypt species as part of their natural diet. We measured food consumption and detoxification metabolites of possums on these diets. Consistent with the hypothesis, animals presented with a choice of both diets consumed more food than animals given diets singly. One of the two indicators of detoxification, acid load in urine, differed significantly between diets while the other, glucuronic acid, did not. These results provide partial support for the hypothesis that diet breadth is governed by detoxification abilities.     

Optimization of electrically conductive films: Poly(3-methylthiophene) or polypyrrole in Kapton

A method to generate conductive films composed of small amounts of conductive polymer absorbed into the surface of polyimide films has been optimized. Both pyrrole (PY) and 3-methylthiophene (3MT) were evaluated as precursors for the conductive phase. Predictive models were empirically derived for each precursor to describe the effects of polymerization variables on the conductivity of the films. The variables studied were found to be highly synergistic. An optimum set of conditions was found for each conductive polymer that produces the highest conductivity. Using p-3MT as the conductive phase, films with conductivity as high as 5.7 Ω⁻¹ cm⁻¹ can be produced, an improvement of four orders of magnitude over previously reported results with Kapton as a base polymer. The highest conductivity achieved using p-PY as the conductive phase was 0.041 Ω⁻¹ cm⁻¹, still a two order of magnitude improvement over previously reported results. Mean mechanical properties of the 3MT-treated films were not significantly lower than that for untreated Kapton. The conductivities of p-3MT/Kapton films tested over time under ambient temperature in air persist fairly well for 300 days. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 63: 821–834, 1997     

Salt-Sensitive Hypertension in GR+/− Rats Is Accompanied with Dysregulation in Adrenal Soluble Epoxide Hydrolase and Polyunsaturated Fatty Acid Pathways

Mutations within the glucocorticoid receptor (GR) gene locus lead to glucocorticoid resistance which is characterized by several clinical symptoms such as adrenal gland hyperplasia and salt-sensitive hypertension, although the underlying mechanisms are still unknown. We studied GR haploinsufficient (GR^+/−) Sprague Dawley rats which, on a standard diet, showed significantly increased plasma aldosterone and corticosterone levels and an adrenocortex hyperplasia accompanied by a normal systolic blood pressure. Following a high salt diet, these rats developed salt-sensitive hypertension and maintained elevated enzyme-soluble epoxide hydrolase (sEH) in adrenal glands, while sEH was significantly decreased in wild-type rats. Furthermore, GR^+/− rats showed dysregulation of the equilibrated linoleic and arachidonic acid pathways, with a significant increase of less active metabolites such as 8,9-DiHETrE. In Sprague Dawley rats, GR haploinsufficiency induced steroid disturbances, which provoked hypertension only in combination with high salt intake, which was accompanied by disturbances in sEH and fatty acid metabolism. Our results suggest that sEH inhibition could be a potential target to treat hypertension in patients with GR haploinsufficiency.     

Stress appraisal in women with spinal cord injury: Supplementary findings through mixed methods.

A study was conducted to examine how women with spinal cord injury (SCI) perceive the stressors they encounter, and how cognitive appraisal is associated with coping and life satisfaction. Fifty women with SCI were interviewed regarding their experience with stress and coping. The interviews were then coded using a framework based on stress and coping theory (transactional model). The systematic application of quantitative methods to the coded interview data allowed for statistical analyses, which demonstrated that the context in which the women spoke about their experiences with various stressors was associated with coping strategies, time since injury, and life satisfaction. Although stress and coping are commonly seen as interacting constructs that influence quality of life outcomes, current findings suggest that appraisal of stressors in the context of loss (more common among women more recently injured) may have a direct impact on life satisfaction apart from any coping strategies put into effect. Interventions designed to facilitate coping with loss and enhance problem-solving skills, along with education about available resources, may foster a sense of empowerment after SCI and ultimately change how stressors are perceived and managed in order to dampen their negative impact on life satisfaction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hope-focused practices during early psychotherapy sessions: Part II: Explicit approaches.

An avalanche of research on hope over the last 30 years consistently points to the benefits of hope in living and human change processes. Common factors models name hope as one of four key factors accounting for client change across psychotherapeutic models. While research provides evidence for the importance of hope, little research examines how hope is understood and practiced. This paper, the second in a two-part series, examines hope-focused interventions of 5 hope-educated psychotherapists with 11 clients early in the therapy sequence. Two categories characterized the overall findings: implicit and explicit hope-focused interventions. The first paper in this series addressed implicit hope-focused interventions. This second paper focuses on explicit hope-focused interventions (i.e., using the word hope, hoping, etc.). Explicit use of hope in therapy was found to address: (a) multiple dimensions of hope (i.e., cognitive, behavioral, emotional, relational); (b) psychoeducational hope interventions; and (c) framing problems as threats to hope. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mycotoxins in Bovine Milk and Dairy Products: A Review

This paper presents a literature review of the occurrence of several mycotoxins in bovine milk and dairy products, because it is the main type of milk produced and marketed worldwide. Mycotoxins are produced by different genera of filamentous fungi and present serious health hazards such as carcinogenicity and mutagenicity. Under favorable growth conditions, toxigenic fungi produce mycotoxins which contaminate the lactating cow's feedstuff. During metabolism, these mycotoxins undergo biotransformation and are secreted in milk. Data show that there is a seasonal trend in the levels of mycotoxins in milk, with these being higher in the cold months probably due to the prolonged storage required for the cattle feeds providing favorable conditions for fungal growth. Good agricultural and storage practices are therefore of fundamental importance in the control of toxigenic species and mycotoxins. Although aflatoxins (especially aflatoxin M₁) are the mycotoxins of greater incidence in milk and dairy products, this review shows that other mycotoxins, such as fumonisin, ochratoxin A, trichothecenes, zearalenone, T‐2 toxin, and deoxynivalenol, can also be found in these products. Given that milk is widely consumed and is a source of nutrients, especially in childhood, a thorough investigation of the occurrence of mycotoxins as well the adoption of measures to minimize their contamination of milk is essential.