Biopreservative technologies of food: an alternative to chemical preservation and recent developments

Food Science and Biotechnology - Despite centuries of developing strategies to prevent food-associated illnesses, food safety remains a significant concern, even with multiple technological...     

Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway

Doxorubicin increases endothelial permeability, hence increasing cardiomyocytes’ exposure to doxorubicin (DOX) and exposing myocytes to more immediate damage. Reactive oxygen species are major effector molecules of doxorubicin’s activity. Mangiferin (MGN) is a xanthone derivative that consists of C-glucosylxanthone with additional antioxidant properties. This particular study assessed the effects of MGN on DOX-induced cytotoxicity in human umbilical vein endothelial cells’ (HUVECs’) signaling networks. Mechanistically, MGN dramatically elevated Nrf2 expression at both the messenger RNA and protein levels through the upregulation of the PI3K/AKT pathway, leading to an increase in Nrf2-downstream genes. Cell apoptosis was assessed with a caspase-3 activity assay, transferase-mediated dUTP-fluorescein nick end labeling (TUNEL) staining was performed to assess DNA fragmentation, and protein expression was determined by Western blot analysis. DOX markedly increased the generation of reactive oxygen species, PARP, caspase-3, and TUNEL-positive cell numbers, but reduced the expression of Bcl-2 and antioxidants’ intracellular concentrations. These were effectively antagonized with MGN (20 μM), which led to HUVECs being protected against DOX-induced apoptosis, partly through the PI3K/AKT-mediated NRF2/HO-1 signaling pathway, which could theoretically protect the vessels from severe DOX toxicity.     

Sensitivity-based conceptual design and tolerance allocation using the continuous ants colony algorithm (CACO)

In an assembly, there are two ways to control the deviation of critical dimensions. One is by keeping the deviation of the critical dimension small by tightening manufacturing tolerances and controlling aging and environmental effects. This approach is traditional and expensive, as it requires tighter manufacturing tolerances and protection from aging and the environment. The second is by moving the nominal values of the non-critical dimensions to a less sensitive portion. This approach is very helpful in improving the quality with no additional cost. One can analyze any number of designs very early in the concept development stage of a project. After the concept design the cost-based optimal tolerances for the corresponding dimensions are allocated. The continuous ants colony algorithm, a kind of meta-heuristic approach, is used as an optimization tool for minimizing the critical dimension deviation and allocating the cost- based optimal tolerances.     

Thermal transport properties of carbon-assisted phase change nanocomposite

Abstract

In this study, stability, density, rheology, and thermal conductivity of the Multi-wall carbon nanotubes (MWCNTs) based PCM nanocomposites were experimentally investigated. The PCM OM08 has been selected for the air-conditioning application with a phase change temperature of 8–10?°C. PCM nanocomposites (without surfactant) in various concentrations namely 0.05, 0.1, 0.3 and 0.5?vol. % were prepared using a typical two-step method and high homogenous stability is achieved using a mechanical mixing technique (ultra-sonication). The density of PCM nanocomposites was measured using two different types of standard volumetric flask approach and the experimental values confirmed good conformity with the Pak and Cho mixing theory. The highest thermal conductivity augmentation of 24.03%and 64.04% were achieved in liquid and solid states, respectively, with 0.5?vol. % of MWCNT. While, the addition of MWCNT resulted in a changeover of Newtonian to Non-Newtonian behaviors at a low shear rate, and the dynamic viscosity enhancement was increased by 130% with 0.5?vol. % of MWCNT. Further, the results were compared with existing correlations and it was found that the experimental values were in line with existing correlations.     

Region based coronary artery segmentation using modified Frangi's vesselness measure

Recent research suggests that the cardiovascular diseases (CVDs), seem to be the foremost cause of mortality among the world populace. Three dimensional (3D) imaging modality such as computed tomography angiography(CTA) is a standard noninvasive imaging modality which has great potentials for the visualization of heart and coronary arteries. This article presents a fully automated method for coronary artery extraction using modified Frangi's vesselness measure and region based segmentation. In this article, grayness and gradient based measures are used while computing Frangi's vesselness measure to improve the extraction of coronary arteries. The obtained vesselness measures are utilized for automatically computing the location of ostia. The locations of ostia are then used as starting seed points in region growing segmentation to extract coronary arteries. Three major coronary arteries, namely the left anterior descending artery (LAD), left circumflex artery (LCX) and right coronary artery (RCA) are segmented using the proposed method and the centerlines are extracted for the main coronary branches. The performance of the proposed method is evaluated using 12 3D CCTA data set. The experimental results reveal that during the calculation of modified Frangi's vesselness measure the proposed method gives improved results. The qualitative results obtained during the segmentation stage are also convincing. The average segmentation accuracy and overlap measure of the proposed method are 97.4% and 77.86%, respectively. Hence, the proposed automated approach can detect and extract coronary arteries in CCTA images with high performance.     

Hydrothermally synthesized ZnO and Z-rGO nanorods: Effect of post-annealing temperature and rGO incorporation on hydrogen sensing

Journal of Materials Science: Materials in Electronics - In this work, hydrogen-sensing characteristics of zinc oxide nanorods and reduced graphene oxide-incorporated zinc oxide nanorods are...     

Scalable Lanthanum Titanate (La2Ti2O7) nanostructures as UV photodetectors

Thermally and chemically stable perovskite-like layer structures have attracted extensively in the field of energy and environmental applications. In this study, La₂Ti₂O₇ was synthesized by the solvothermal method at 180 °C. This method provides high pure and homogeneously dispersed nanorods of orthorhombic phase having length of 250 nm and width of 70 nm. Even though this is a low-temperature synthesis method, it yields high crystalline nature after calcination. The novelty of this work is its synthesis methodology by the solvothermal route to achieve lower weight loss of La₂Ti₂O₇. Furthermore, they exhibit narrow absorption in the UV-region from 200 to 350 nm, makes it possible to fabricate it as UV photodetector at ambient condition. In presence of UV illumination at 390 nm, it shows sharp photocurrent response with the decay time of 1.7 s.

     

Cellulose acetate and sulfonated polysulfone blend ultrafiltration membranes. I. Preparation and characterization

Modification of polymeric membrane materials by incorporation of hydrophilicity results in membranes with low fouling behavior and high flux. Hence, Polysulfone was functionalized by sulfonation and ultrafiltration membranes were prepared based on sulfonated polysulfone and cellulose acetate in various blend compositions. Polyethyleneglycol 600 was employed as a nonsolvent additive in various concentrations to the casting solution to improve the ultrafiltration performance of the resulting membranes. The total polymer concentration, cellulose acetate, and sulfonated polysulfone polymer blend composition, additive concentration, and its compatibility with polymer blends were optimized. The membranes prepared were characterized in terms of compaction, pure water flux, membrane resistance, and water content. The compaction takes place within 3–4 h for all the membranes. The pure water flux is determined largely by the composition of sulfonated polysulfone and concentration of additive. Membrane resistance is inversely proportional to pure water flux, and water content is proportional to pure water flux for all the membranes. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1749–1761, 2002     

Optimization of machining parameters using genetic algorithm and experimental validation for end-milling operations

Optimization of cutting parameters is valuable in terms of providing high precision and efficient machining. Optimization of machining parameters for milling is an important step to minimize the machining time and cutting force, increase productivity and tool life and obtain better surface finish. In this work a mathematical model has been developed based on both the material behavior and the machine dynamics to determine cutting force for milling operations. The system used for optimization is based on powerful artificial intelligence called genetic algorithms (GA). The machining time is considered as the objective function and constraints are tool life, limits of feed rate, depth of cut, cutting speed, surface roughness, cutting force and amplitude of vibrations while maintaining a constant material removal rate. The result of the work shows how a complex optimization problem is handled by a genetic algorithm and converges very quickly. Experimental end milling tests have been performed on mild steel to measure surface roughness, cutting force using milling tool dynamometer and vibration using a FFT (fast Fourier transform) analyzer for the optimized cutting parameters in a Universal milling machine using an HSS cutter. From the estimated surface roughness value of 0.71 μm, the optimal cutting parameters that have given a maximum material removal rate of 6.0×10³ mm³/min with less amplitude of vibration at the work piece support 1.66 μm maximum displacement. The good agreement between the GA cutting forces and measured cutting forces clearly demonstrates the accuracy and effectiveness of the model presented and program developed. The obtained results indicate that the optimized parameters are capable of machining the work piece more efficiently with better surface finish.     

Biodegradable biocomposites from poly(butylene adipate‐co‐terephthalate) and miscanthus: Preparation,compatibilization, and performance evaluation

Miscanthus fibers reinforced biodegradable poly(butylene adipate‐co‐terephthalate) (PBAT) matrix‐based biocomposites were produced by melt processing. The performances of the produced PBAT/miscanthus composites were evaluated by means of mechanical, thermal, and morphological analysis. Compared to neat PBAT, the flexural strength, flexural modulus, storage modulus, and tensile modulus were increased after the addition of miscanthus fibers into the PBAT matrix. These improvements were attributed to the strong reinforcing effect of miscanthus fibers. The polarity difference between the PBAT matrix and the miscanthus fibers leads to weak interaction between the phases in the resulting composites. This weak interaction was evidenced in the impact strength and tensile strength of the uncompatibilized PBAT composites. Therefore, maleic anhydride (MAH)‐grafted PBAT was prepared as compatibilizer by melt free radical grafting reaction. The MAH grafting on the PBAT was confirmed by Fourier transform infrared spectroscopy. The interfacial bonding between the miscanthus fibers and PBAT was improved with the addition of 5 wt % of MAH‐grafted PBAT (MAH‐g‐PBAT) compatibilizer. The improved interaction between the PBAT and the miscanthus fiber was corroborated with mechanical and morphological properties. The compatibilized PBAT composite with 40 wt % miscanthus fibers exhibited an average heat deflection temperature of 81 °C, notched Izod impact strength of 184 J/m, tensile strength of 19.4 MPa, and flexural strength of 22 MPa. From the scanning electron microscopy analysis, better interaction between the components can be observed in the compatibilized composites, which contribute to enhanced mechanical properties. Overall, the addition of miscanthus fibers into a PBAT matrix showed a significant benefit in terms of economic competitiveness and functional performances. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45448.