Nitrogen dynamics during till and no-till pasture restoration sequences in Rondônia,Brazil

The clearing of tropical rain forest in the Amazon basin has created large areas of cattle pasture that are now declining in productivity. Practices adopted by ranchers to restore productivity to degraded pastures have the potential to alter soil N availability and gaseous N losses from soils. We examined how soil inorganic N pools, net N mineralization and net nitrification rates, nitrification potential and NO and N₂O emissions from soils of a degraded pasture responded to the following restoration treatments: (1) soil tillage followed by replanting of grass and fertilization, (2) no-till application of non-selective herbicide, planting of rice, harvest followed by no-till replanting of grass and fertilization, and (3) the same no-till sequence with soybeans instead of rice. Tillage increased soil NH₄⁺ and NO₃^? pools but NH₄⁺ and NO₃^? pools remained relatively constant in the control and no-till treatments. Cumulative rates of net N mineralization and net nitrification during the first 6 months after treatment varied widely but were hightest in the tilled treatment. Emissions of NO and N₂O fluxes increased with tillage and with N fertilization. There were no clear relationships among rates of N fertilizer application, net N mineralization, net nitrification, NO, N₂O and total N oxide emissions. Our results indicate that pasture restoration sequences involving tilling and fertilizing will increase emissions of N oxides, but the magnitude of the increase is likely to differ based on timing of fertilizer application relative to the presence of plants and the magnitude of plant N demand. Emissions of N oxides appear to be decreased by the use of restoration sequences that minimize reductions in pasture grass cover.     

Adherence rates to ferric citrate as compared to active control in patients with end stage kidney disease on dialysis

Introduction: Oral phosphate binders are the main stay of treatment of hyperphosphatemia. Adherence rates to ferric citrate, a recently approved phosphate binder, are unknown. Methods: We conducted a post‐hoc analysis to evaluate whether adherence rates were different for ferric citrate vs. active control in 412 subjects with end stage kidney disease (ESKD) who were randomized to ferric citrate vs. active control (sevelamer carbonate and/or calcium acetate). Adherence was defined as percent of actual number of pills taken to total number of pills prescribed. Findings: There were no significant differences in baseline characteristics including gender, race/ethnicity, and age between the ferric citrate and active control groups. Baseline phosphorus, calcium, and parathyroid hormone levels were similar. Mean (SD) adherence was 81.4% (17.4) and 81.7% (15.9) in the ferric citrate and active control groups, respectively (P = 0.88). Adherence remained similar between both groups after adjusting for gender, race/ethnicity, age, cardiovascular disease (CVD), and diabetic nephropathy (mean [95% CI]: 81.4% [78.2, 84.6] and 81.5% [77.7, 85.2] for ferric citrate and active control, respectively). Gender, race/ethnicity, age, and diagnosis of diabetic nephropathy did not influence adherence to the prescribed phosphate binder. Subjects with CVD had lower adherence rates to phosphate binder; this was significant only in the active control group. Discussion: Adherence rates to the phosphate binder, ferric citrate, were similar to adherence rates to active control. Similar adherence rates to ferric citrate are notable since tolerance to active control was an entry criteria and the study was open label. Gender, race/ethnicity, nor age influenced adherence.     

Inhibition of dicing of guanosine-rich shRNAs by quadruplex-binding compounds

RNA interference is triggered by small hairpin precursors that are processed by the endonuclease dicer to yield active species such as siRNAs and miRNAs. To regulate the RNAi-mediated suppression of gene expression, we imagined a strategy that relies on the sequence-specific inhibition of shRNA precursor processing by immediate RNA-small molecule interactions. Here, we present a first step in this direction by augmenting shRNAs with guanosine-rich sequences that are prone to fold into four-stranded structures. The addition of small molecules that selectively bind to such quadruplex sequences should allow for the specific inhibition of dicing of shRNAs that contain suitable G-rich elements. In an attempt to find compounds that protect against dicer processing, we have examined the effects of quadruplex-binding compounds on the dicer processing of shRNAs containing G-quadruplexes. Although a variety of small molecules that are known to bind to quadruplexes inhibited in vitro dicing of shRNAs, only two substance classes, namely certain porphyrazines and bisquinolinium compounds, showed selective inhibition of G-rich shRNAs compared to control sequences lacking guanine-rich elements. The G-rich shRNAs displayed a potent knockdown of gene expression in mammalian cell culture, but the effect was not influenced by addition of the respective quadruplex-binding compounds.     

Delay classical conditioning in young and older rabbits: Initial acquisition and retention at 12 and 18 months.

Classical conditioning of the nictitating membrane-eyeblink response in young (age 7 mo) and older (age 36 mo) New Zealand white rabbits in a delay paradigm with 400-msec CS–unconditioned stimulus/stimuli (UCS) interval was examined for initial acquisition and retention. Older animals required significantly more acquisition trials to reach learning criterion. Age differences in acquisition were temporary. Older rabbits responded at a level comparable to that of young rabbits such that total performance over the 630 trials of acquisition was not different. Rabbits in the explicitly unpaired control groups exhibited no age differences in unconditioned response (UCR) amplitude or latency measures. 12- and 18-mo retests demonstrated no significant age effects on retention. Patterns of retention differed between age groups. Older rabbits required fewer trials to obtain the learning criterion at each phase of testing. Younger rabbits maintained a stable performance throughout training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relationship between the extent of reciprocity with social supporters and measures of depressive symptomatology, impairment, disability, and handicap in persons with spinal cord injury.

140 adults (aged 19–77 yrs) were randomly selected from a sampling frame of 661 persons with spinal cord injury. They completed a questionnaire assessing amount of social support, degree of reciprocity with supporters, and satisfaction with relationships with supporters; the Center for Epidemiologic Studies Depression Scale; a self-report version of the Functional Independence Measure; and the Craig Handicap Assessment and Reporting Technique. A physician assessed the degree of paralytic impairment by means of the ASIA Total Motor Index Score. Relationships in which the supporter gave more than the participant were associated with more satisfaction with the relationship and more social support. The number of reciprocal relationships was positively associated with more desirable outcomes in the handicap dimensions of mobility, occupation, social integration, and economic self-sufficiency. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of environmental daily temperature fluctuations over one year storage on the prediction of non-enzymatic browning in reduced-moisture foods stored at “ambient” temperature

Non-enzymatic browning predictions in reduced-moisture foods stored over one year at “ambient” temperature, were made using, (a) realistic environmental daily (and seasonal) temperature fluctuations, and (b) a constant mean temperature. Daily temperature records taken every 6 h from January 1st to December 31st (1460 temperature data) in four selected cities from Argentina, were used.

The predicted amount of browning over one year storage was different depending whether the annual mean temperature (T_am), the monthly mean temperature (T_mm) or the daily temperature fluctuations (T_df) were used for the predictions. Predicted browning over one year was generally higher when realistic storage conditions (i.e., daily/seasonal temperature fluctuations) rather than mean values (annual or monthly), were used instead.     

The Bauhaus as cultural paradigm

In the first Bauhaus Manifesto of 1919, Gropius refers to the 'new structure of the future' which the school will conceive and create, a structure which will 'rise towards heaven ... like the crystal symbol of a new faith'. While there is no shortage of literature on the Bauhaus, the nature of the programme of redemption to which the school aspired is seldom explored. By studying the origins of the school and focusing on the way in which its aims were put into practice for the International Exhibition of 1923, particularly through the experimental house and the Bauhaus stage, this essay attempts to look more closely at the 'cultural paradigm' proposed by the Bauhaus.     

A stochastic optimal feedback control problem with random-sized jumps

An optimal feedback control problem for a partially observed linear system with noise of fixed-sized jumps occurring at random times driven by a Poisson process is extended to include noise with random-sized jumps. The control structure is appropriately modified to compensate for the mean behavior of the system jumps via an additional deterministic term. Editor: N.U. Ahmed     

Distribution damage measurement,analysis and correction

Distribution damage is a symptom of underlying problems—a quality system out of adjustment. The purpose of this paper is to develop a management method for controlling distribution damage. Such a system includes setting standards and managing conformance through appraisal and corrective action, including package improvement through damage reproduction test method evaluation.     

Towards an educational Superlnterface

Abstract  It is presumed that recent technological innovations, combined with three more established (educational) technologies, could cause a drastic change in university education, if adequate organizational conditions could be created. Such conditions are needed to structure, channel and manage an as yet undreamed of flow of information. Closely related to the metaphor of the 'Info Highway', an educational 'Superlnterface' is described. Based upon networked computer platforms, such a human-computer-human interface is to support large scale telestudy (and teleworking). The Superlnterface is to be designed or is to evolve in such a way that reliable and valid organizational foundations for university education can be established. As the organizational foundation is so paramount, the authors would like to see serious research into the modelling of Superlnterface structures, resources, and dynamics. Indications of some such research issues are presented.