Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice

We evaluated ethanol- and HCl-induced mucosal damages in developing rats. The degree of damage induced by ethanol and HCl was greatest in 1-week-old rats and decreased significantly with age until 4 weeks; thereafter it increased again. To evaluate the effect of weaning on the maturational changes in mucosal defense, we compared ethanol-induced mucosal damage among three groups of newborn rats: (1) receiving milk only; (2) receiving only rat chow from 14 days of age, and (3) having free access to milk and chow. There were no significant differences at 18 and 21 days of age. The mucus thickness increased with age until 8 weeks and was not affected by weaning. In conclusion, developmental changes occur in gastric mucosal protection in rats. Weaning does not have a significant effect on these changes.     

Gap inner pressures in multi-storey double skin facades

Double-skin façades (DSF) are used as an architectural solution to improve indoor comfort being characterized by having at least two membranes between the interior occupied space and the exterior environment, separated by an air gap where the shading devices lie. The pressure within the gap plays an important role on (i) the glazing structural safety; (ii) the shaft ventilation, in particular if a natural ventilation scheme is implemented, but also to promote an efficient gap air change, and (iii) the safety of maintenance staff, especially when windows may be opened to the interior. Although there are several DSF typologies only the multi-storey case, where no horizontal or vertical partitioning exists between the two skins, will be analysed in this paper. Nevertheless, there are still a number of possible layouts for multi-storey DSF that might impose different pressure distributions within the gap. This paper refers to a set of wind tunnel tests made over a building model with different multi-storey DSF layouts—from open on all edges to fully lateral closure and from narrow to wide gap depths, for an extended range of wind directions. The experimental data showed a layout dependent inner wall pressure distribution that may be considerably different from the unsheltered building.     

Wideband low-distortion delta-sigma ADC topology

A ΔΣ topology with reduced sensitivity to opamp nonlinearities is described. The technique is effective even for very low oversampling ratios, and can be used for any modulation order. Techniques for reducing other nonideal effects are also proposed     

Production of biodiesel by esterification of palmitic acid over mesoporous aluminosilicate Al-MCM-41

Biodiesel has been obtained by esterification of palmitic acid with methanol, ethanol and isopropanol in the presence of Al-MCM-41 mesoporous molecular sieves with Si/Al ratios of 8, 16 and 32. The catalytic acids were synthesized at room temperature and characterized by atomic absorption spectrometry (AAS), thermal analysis (TG/DTA), X-ray diffraction (XRD), nitrogen absorption (BET/BJH), infrared spectroscopy (IR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The reaction was carried out at 130 °C whilst stirring at 500 rpm, with an alcohol/acid molar ratio of 60 and 0.6 wt% catalyst for 2 h. The alcohol reactivity follows the order methanol > ethanol > isopropanol. The catalyst Al-MCM-41 with ratio Si/Al = 8 produced the largest conversion values for the alcohols studied. The data followed a rather satisfactory approximation to first-order kinetics.     

Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use

Background  

Preterm infants need high amounts of calcium and phosphorus for bone mineralization, which is difficult to obtain with parenteral feeding due to the low solubility of these salts. The objective of this study was to evaluate the physicochemical compatibility of high concentrations of calcium associated with organic phosphate and its influence on the stability of AIO admixtures for neonatal use.     

Improving Power System Reliability Calculation Efficiency With EPSO Variants

This paper presents an application of evolutionary particle swarm optimization (EPSO)-based methods to evaluate power system reliability. Population-based (PB) methods appear as competitors to the traditional Monte Carlo simulation (MCS), because they are computationally efficient in estimating a variety of reliability indices. The work reported in this paper demonstrates that EPSO variants can focus the search in the region of the state space where contributions to the formation of a reliability index may be found, instead of conducting a blind sampling of the space. The results obtained with EPSO are compared to MCS and with other PB methods.     

A simple procedure to improve the pressure evaluation in hydrodynamic context using the SPH

In literature, it is well know that the Smoothed Particle Hydrodynamics method can be affected by numerical noise on the pressure field when dealing with liquids. This can be highly dangerous when an SPH code is dynamically coupled with a structural solver. In this work a simple procedure is proposed to improve the computation of the pressure distribution in the dynamics of liquids. Such a procedure is based on the use of a density diffusion term in the equation for the mass conservation. This diffusion is a pure numerical effect, similar to the well known artificial viscosity originally proposed in SPH method to smooth out the shock discontinuities. As the artificial viscosity, the density diffusion used here goes to zero increasing the number of particles recovering consistency and convergence of the final numerical scheme adopted. Different artificial density diffusion formulas have been studied, paying attention to prevent unphysical changes of the flows. To show the improvements of the new scheme proposed here, a suitable set of examples, for which reference solutions or experimental data are available, has been tested.     

Long-term stability of hydrogen and organic acids production in an anaerobic fluidized-bed reactor using heat treated anaerobic sludge inoculum

This study evaluates the stability of hydrogen and organic acids production in an anaerobic fluidized-bed reactor (AFBR) that contains expanded clay (2.8–3.35 mm in diameter) as a support medium and is operated on a long-term basis. The reactor was inoculated with thermally pre-treated anaerobic sludge and operated with decreasing hydraulic retention time (HRT), from 8 h to 1 h, at a controlled temperature of 30 °C and a pH of about 3.8. Glucose (2000 mg L^?1) was used as the substrate, generating conversion rates of 92–98%. Decreasing the HRT from 8 h to 1 h led to an increase in average hydrogen-production rates, with a maximum value of 1.28 L h^?1 L^?1 for an HRT of 1 h. In general, hydrogen yield production increased as HRT decreased, reaching 2.29 mol of H₂/mol glucose at an HRT of 2 h and yielding a maximum hydrogen content of 37% in the biogas. No methane was detected in the biogas throughout the period of operation. The main soluble metabolites (SMP) were acetic acid (46.94–53.84% of SMP) and butyric acid (34.51–42.16% of SMP), with less than 15.49% ethanol. The steady performance of the AFBR may be attributed to adequate thermal treatment of the inoculum, the selection of a suitable support medium for microbial adhesion, and the choice of satisfactory environmental conditions imposed on the system. The results show that stable hydrogen production and organic acids production were maintained in the AFBR over a period of 178 days.     

Immobilization of β-cyclodextrin on gold surfaces by chemical derivatization of an 11-amino-1-undecanthiol self-assembled monolayer

A new methodology for the covalent functionalization of a SAM of 11-amino-1-undecanethiol, previously adsorbed on polycrystalline Au, was successfully applied in order to immobilize a β-CD layer on surface. A two steps synthetic strategy is proposed based on the activation of the SAM with di-(N-succinimidyl) carbonate for the further inclusion of the β-CD. The modification of the SAM was followed by PM-FTIRRAS, AFM imaging, CV, and EIS which confirmed the introduction of β-CD layer. The AFM images allowed the identification of homogeneously distributed β-CD aggregates over the Au grain microstructure. The electrode was characterized in the presence of electroactive species in solution, with the ability to form inclusion complexes with the β-CD cavity. Contrary to the reported for other thiolated CD derivative films, the results of this study showed the formation of well-packed and compact structures which strongly reduce non-specific adsorption phenomena. The redox response of the probes at the β-CD electrode was shown to appear at higher potentials with respect to the response at bare Au. Good correlation was found between the increase of the hydroquinone oxidation peak and, both, the scan rate used in CV experiments (typical behavior of surface-confined species) and the hydroquinone concentration. In the case of dopamine, the processes seem to shifted out of the potential window of SAM stability. The results suggest that this problem could be overcome by improving the design of the device.