全文获取类型
收费全文 | 761篇 |
免费 | 42篇 |
专业分类
电工技术 | 14篇 |
综合类 | 6篇 |
化学工业 | 252篇 |
金属工艺 | 6篇 |
机械仪表 | 40篇 |
建筑科学 | 21篇 |
能源动力 | 23篇 |
轻工业 | 90篇 |
水利工程 | 5篇 |
石油天然气 | 1篇 |
无线电 | 33篇 |
一般工业技术 | 96篇 |
冶金工业 | 23篇 |
原子能技术 | 11篇 |
自动化技术 | 182篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 58篇 |
2021年 | 59篇 |
2020年 | 25篇 |
2019年 | 26篇 |
2018年 | 21篇 |
2017年 | 24篇 |
2016年 | 37篇 |
2015年 | 17篇 |
2014年 | 31篇 |
2013年 | 57篇 |
2012年 | 59篇 |
2011年 | 47篇 |
2010年 | 40篇 |
2009年 | 32篇 |
2008年 | 30篇 |
2007年 | 29篇 |
2006年 | 23篇 |
2005年 | 27篇 |
2004年 | 14篇 |
2003年 | 22篇 |
2002年 | 21篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 11篇 |
1998年 | 4篇 |
1997年 | 17篇 |
1996年 | 8篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1975年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有803条查询结果,搜索用时 109 毫秒
101.
Alessandra Di Paola Giuseppe Palumbo Pietro Merli Maura Argenziano Chiara Tortora Luisa Strocchio Domenico Roberti Claudia Santoro Silverio Perrotta Francesca Rossi 《International journal of molecular sciences》2021,22(1)
Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibodies-mediated platelet destruction, a prevalence of M1 pro-inflammatory macrophage phenotype and an elevated T helper 1 and T helper 2 lymphocytes (Th1/Th2) ratio, resulting in impairment of inflammatory profile and immune response. Macrophages are immune cells, present as pro-inflammatory classically activated macrophages (M1) or as anti-inflammatory alternatively activated macrophages (M2). They have a key role in ITP, acting both as effector cells, phagocytizing platelets, and, as antigen presenting cells, stimulating auto-antibodies against platelets production. Eltrombopag (ELT) is a thrombopoietin receptor agonist licensed for chronic ITP to stimulate platelet production. Moreover, it improves T and B regulatory cells functions, suppresses T-cells activity, and inhibits monocytes activation. We analyzed the effect of ELT on macrophage phenotype polarization, proposing a new possible mechanism of action. We suggest it as a mediator of macrophage phenotype switch from the M1 pro-inflammatory type to the M2 anti-inflammatory one in paediatric patients with ITP, in order to reduce inflammatory state and restore the immune system function. Our results provide new insights into the therapy and the management of ITP, suggesting ELT also as immune-modulating drug. 相似文献
102.
Dr. Jessica Ceramella Dr. Annaluisa Mariconda Dr. Camillo Rosano Dr. Domenico Iacopetta Dr. Anna Caruso Prof. Pasquale Longo Prof. Maria Stefania Sinicropi Prof. Carmela Saturnino 《ChemMedChem》2020,15(23):2306-2316
Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well-known microtubule-targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use. To find new candidates able to induce microtubule alteration with reduced toxic effects or drug resistance, we studied a small new series of derivatives that present imidazolinic, guanidinic, thioureidic and hydrazinic groups ( 1 – 9 ). All the compounds were tested for their antitumor activity against a panel of six tumoral cell models. In particular, compound 8 (nonane-1,9-diyl-bis-S-amidinothiourea dihydrobromide) showed the lowest IC50 value against HeLa cells, together with a low cytotoxicity for normal cells. This compound was able to induce the apoptotic mitochondrial pathway and inhibited tubulin polymerization with a similar efficacy to vinblastine and nocodazole. Taken together, these promising biological properties make compound 8 useful for the development of novel therapeutic approaches in cancer treatment. 相似文献
103.
Dr. Rosaria Ciriminna Dr. Alexandra Fidalgo Dr. Francesco Meneguzzo Dr. Alessandro Presentato Dr. Antonino Scurria Dr. Domenico Nuzzo Prof. Rosa Alduina Prof. Laura M. Ilharco Dr. Mario Pagliaro 《ChemMedChem》2020,15(23):2228-2235
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering. 相似文献
104.
Bruni Vittoria Tartaglione Michela Vitulano Domenico 《Multimedia Tools and Applications》2022,81(16):22653-22676
Multimedia Tools and Applications - This paper presents a method for Photo Response Non Uniformity (PRNU) pattern noise based camera identification. It takes advantage of the coherence between... 相似文献
105.
Nicola Alessio Domenico Aprile Salvatore Cappabianca Gianfranco Peluso Giovanni Di Bernardo Umberto Galderisi 《International journal of molecular sciences》2021,22(6)
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0 state of quiescence or, alternatively, they may undergo an irreversible G0 state. The latter may be a physiological differentiation or, following a stress event, a senescent status. Discrimination among the several G0 states represents a significant investigation, since quiescence, differentiation, and senescence are progressive phenomena with intermediate transitional stages. We used the expression of Ki67, RPS6, and beta-galactosidase to identify healthy cells that progressively enter and leave quiescence through G0-entry, G0 and G0-alert states. We then evaluated how cells may enter senescence following a genotoxic stressful event. We identified an initial stress stage with the expression of beta-galactosidase and Ki67 proliferation marker. Cells may recover from stress events or become senescent passing through early and late senescence states. Discrimination between quiescence and senescence was based on the expression of RPS6, a marker of active protein synthesis that is present in senescent cells but absent in quiescent cells. Even taking into account that fixed G0 states do not exist, our molecular algorithm may represent a method for identifying turning points of G0 transitional states that continuously change. 相似文献
106.
107.
Danilo Tardioli Luis Riazuelo Domenico Sicignano Carlos Rizzo Francisco Lera Jos L. Villarroel Luis Montano 《野外机器人技术杂志》2019,36(6):1074-1101
The work reported in this article describes the research advances and the lessons learned by the Robotics, Perception and Real‐Time group over a decade of research in the field of ground robotics in confined environments. This study has primarily focused on localization, navigation, and communications in tunnel‐like environments. As will be discussed, this type of environment presents several special characteristics that often make well‐established techniques fail. The aim is to share, in an open way, the experience, errors, and successes of this group with the robotics community so that those that work in such environments can avoid (some of) the errors made. At the very least, these findings can be readily taken into account when designing a solution, without needing to sift through the technical details found in the papers cited within this text. 相似文献
108.
Alberto Castellini Manuele Bicego Domenico Bloisi Jason Blum Francesco Masillo Sergio Peignier 《控制论与系统》2019,50(8):658-671
AbstractIn this paper, we propose the use of subspace clustering to detect the states of dynamical systems from sequences of observations. In particular, we generate sparse and interpretable models that relate the states of aquatic drones involved in autonomous water monitoring to the properties (e.g., statistical distribution) of data collected by drone sensors. The subspace clustering algorithm used is called SubCMedians. A quantitative experimental analysis is performed to investigate the connections between i) learning parameters and performance, ii) noise in the data and performance. The clustering obtained with this analysis outperforms those generated by previous approaches. 相似文献
109.
Laurà R Magnoli D Zichichi R Guerrera MC De Carlos F Suárez AÁ Abbate F Ciriaco E Vega JA Germanà A 《Microscopy research and technique》2012,75(3):359-366
The zebrafish pineal gland plays a fundamental role in the regulation of the circadian rhythm through the melatonin secretion. The pinealocytes, also called photoreceptive cells, are considered the morphofunctional unit of pineal gland. In literature, the anatomical features, the cellular characteristics, and the pinealocytes morphology of zebrafish pineal gland have not been previously described in detail. Therefore, this study was undertaken to analyze the structure and ultrastructure, as well as the immunohistochemical profile of the zebrafish pineal gland with particular reference to the pinealocytes. Here, we demonstrated, using RT-PCR, immunohistochemistry and transmission electron microscopy, the expression of the mRNA for rhodopsin in the pineal gland of zebrafish, as well as its cellular localization exclusively in the pinealocytes of adult zebrafish. Moreover, the ultrastructural observations demonstrated that the pinealocytes were constituted by an outer segment with numerous lamellar membranes, an inner segment with many mitochondria, and a basal pole with the synapses. Our results taken together demonstrated a central role of zebrafish pinealocytes in the control of pineal gland functions. 相似文献
110.
Brent J. Maundy Ahmed S. Elwakil Domenico Zito 《International Journal of Circuit Theory and Applications》2019,47(1):175-185
We propose a novel CMOS differential voltage-controlled equivalent active resistor based on a modified common-source cross-coupled pair. The equivalent resistance exhibited by the circuit can be tuned to be either positive or negative through the tail current, which is controlled by a bias voltage. The complete cell comprises four transistors, two resistors in addition to the bias voltage, and tail current source. Application to the design of oscillators is demonstrated by theoretical analysis, circuit simulations, and verified experimentally through measurements on prototypes implemented using discrete transistors. 相似文献