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排序方式: 共有136条查询结果,搜索用时 140 毫秒
51.
Viktoriia Kyshkarova Dominika Marcin Behunova Inna Melnyk Seda Demirel Topel 《应用聚合物科学杂志》2024,141(8):e55001
Rare earth elements play a pivotal role in modern technologies, thereby driving an escalating demand for their procurement. To effectively extract these elements from aqueous solutions, it is imperative to explore innovative sorbent materials. In this context, a hydrogel sorbent material was developed by employing poly(vinyl alcohol) (PVA) and shungite—an economical, naturally occurring, easily processable, and sustainable material. This was achieved through the freezing–thawing method, employing sodium borate as a crosslinking agent. The physicochemical characteristics of the hydrogels were determined through scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET) analysis, Zetasizer analysis, and elemental analysis. The shungite-incorporated PVA hydrogels displayed notable characteristics, including a substantial swelling capacity of 61% and a specific surface area of 32.8 m2/g. Most significantly, these hydrogels exhibited a remarkable affinity for La3+ ions, with an uptake ratio of 134 mg/g. This was followed by Nd3+, Dy3+, and Er3+ ions, which displayed uptake ratios of 79, 74, and 73 mg/g, respectively. 相似文献
52.
Elemental and organic carbon in aerosols over urbanized coastal region (southern Baltic Sea, Gdynia) 总被引:2,自引:0,他引:2
Anita Lewandowska Lucyna Falkowska Dominika Murawiec Dorota Pryputniewicz Dorota Burska Magdalena Be?dowska 《The Science of the total environment》2010,408(20):4761-4769
Studies on PM 10, total particulate matter (TSP), elemental carbon (EC) and organic carbon (OC) concentrations were carried out in the Polish coastal zone of the Baltic Sea, in urbanized Gdynia. The interaction between the land, the air and the sea was clearly observed. The highest concentrations of PM 10, TSP and both carbon fractions were noted in the air masses moving from southern and western Poland and Europe. The EC was generally of primary origin and its contribution to TSP and PM 10 mass was on average 2.3% and 3.7% respectively. Under low wind speed conditions local sources (traffic and industry) influenced increases in elemental carbon and PM 10 concentrations in Gdynia. Elemental carbon demonstrated a pronounced weekly cycle, yielding minimum values at the weekend and maximum values on Thursdays. The role of harbors and ship yards in creating high EC concentrations was clearly observed. Concentration of organic carbon was ten times higher than that of elemental carbon, and the average OC contribution to PM 10 mass was very high (31.6%). An inverse situation was observed when air masses were transported from over the Atlantic Ocean, the North Sea and the Baltic Sea. These clean air masses were characterized by the lowest concentrations of all analysed compounds.Obtained results for organic and elemental carbon fluxes showed that atmospheric aerosols can be treated, along with water run-off, as a carbon source for the coastal waters of the Baltic Sea. The enrichment of surface water was more effective in the case of organic carbon (0.27 ± 0.19 mmol m−2 d−1). Elemental carbon fluxes were one order of magnitude smaller, on average 0.03 ± 0.04 mmol m−2 d−1. We suggest that in some situations atmospheric carbon input can explain up to 18% of total carbon fluxes into the Baltic coastal waters. 相似文献
53.
The effect of addition of Nigella sativa L. oil on the quality and shelf life of pork patties
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54.
Dominika M. Wloch‐Salamon Roberta M. Fisher Birgitte Regenberg 《Yeast (Chichester, England)》2017,34(10):399-406
Division of labour between different specialized cell types is a central part of how we describe complexity in multicellular organisms. However, it is increasingly being recognized that division of labour also plays an important role in the lives of predominantly unicellular organisms. Saccharomyces cerevisiae displays several phenotypes that could be considered a division of labour, including quiescence, apoptosis and biofilm formation, but they have not been explicitly treated as such. We discuss each of these examples, using a definition of division of labour that involves phenotypic variation between cells within a population, cooperation between cells performing different tasks and maximization of the inclusive fitness of all cells involved. We then propose future research directions and possible experimental tests using S. cerevisiae as a model organism for understanding the genetic mechanisms and selective pressures that can lead to the evolution of the very first stages of a division of labour. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献
55.
Adrianna W. Bara-Halama Dominika Idziak-Helmcke Jolanta Kwasniewska 《International journal of molecular sciences》2022,23(12)
Many years have passed since micronuclei were first observed then accepted as an indicator of the effect of mutagens. However, the possible mechanisms of their formation and elimination from the cell are still not fully understood. Various stresses, including mutagens, can alter gene expression through changes in DNA methylation in plants. In this study we demonstrate for the first time DNA methylation in the foci of 5S and 35S rDNA sequences in individual Brachypodium distachyon micronuclei that are induced by mutagenic treatment with maleic acid hydrazide (MH). The impact of MH on global epigenetic modifications in nuclei and micronuclei has been studied in plants before; however, no in situ analyses of DNA methylation in specific DNA sequence sites are known. To address this problem, we used sequential immunodetection of 5-methylcytosine and fluorescence in situ hybridization (FISH) with 5S and 25S rDNA probes on the non-dividing cells of B. distachyon. Such investigations into the presence or absence of DNA methylation within specific DNA sequences are extremely important in plant mutagenesis in the light of altering gene expression. 相似文献
56.
Marta Po
niak Dominika ukowska Aleksandra Gdaj Mateusz Adam Krzycik Natalia Porbska Magorzata Zakrzewska Jacek Otlewski ukasz Opaliski 《International journal of molecular sciences》2022,23(15)
Precise anticancer therapies employing cytotoxic conjugates constitute a side-effect-limited, highly attractive alternative to commonly used cancer treatment modalities, such as conventional chemotherapy, radiotherapy or surgical interventions. Receptor tyrosine kinases are a large family of N-glycoproteins intensively studied as molecular targets for cytotoxic conjugates in various cancers. At the cell surface, these receptors are embedded in a dense carbohydrate layer formed by numerous plasma membrane glycoproteins. The complexity of the cell surface architecture is further increased by galectins, secreted lectins capable of recognizing and clustering glycoconjugates, affecting their motility and activity. Cell surface N-glycosylation is intensively remodeled by cancer cells; however, the contribution of this phenomenon to the efficiency of treatment with cytotoxic conjugates is largely unknown. Here, we evaluated the significance of N-glycosylation for the internalization and toxicity of conjugates targeting two model receptor tyrosine kinases strongly implicated in cancer: HER2 and FGFR1. We employed three conjugates of distinct molecular architecture and specificity: AffibodyHER2-vcMMAE (targeting HER2), vcMMAE-KCK-FGF1.E and T-Fc-vcMMAE (recognizing different epitopes within FGFR1). We demonstrated that inhibition of N-glycosylation reduced the cellular uptake of all conjugates tested and provided evidence for a role of the galectin network in conjugate internalization. In vitro binding studies revealed that the reduced uptake of conjugates is not due to impaired HER2 and FGFR1 binding. Importantly, we demonstrated that alteration of N-glycosylation can affect the cytotoxic potential of conjugates. Our data implicate a key role for cell surface N-glycosylation in the delivery of cytotoxic conjugates into cancer cells. 相似文献
57.
Sabina Smoleń Dominika J. Walaszek Maksymilian Karczewski Emil Martin Dorota Gryko 《Israel journal of chemistry》2016,56(2-3):156-168
The pathogenesis of the cardiovascular system is often associated with dysfunction of soluble guanylate cyclase (sGC), which can be stimulated in both an NO-dependent and -independent manner. It was previously reported that PPIX and its amphiphilic derivatives markedly activate the enzyme. To date, all porphyrins studied are naturally occurring compounds or their derivatives, possessing substituents at β-positions. Such porphyrins are of limited abundance and their derivatives or analogues are difficult to synthesize, while synthetic meso-substituted porphyrins are easy to prepare. Thus, we have decided to study their effect on guanylate cyclase. To this end, a series of trans-AB-porphyrins, bearing both hydrophilic and hydrophobic groups at the opposite ends of the macrocycle, loosely mimicking the arrangement of the substituents in PPIX, was design and synthesized. Their synthesis involves preparation of suitable building blocks – dipyrromethanes, starting from aldehydes or acetals and following an acid-catalyzed [2+2]-dipyrromethane condensation. Biological properties of synthesized porphyrins with regard to sGC activation were tested. meso-Substituted porphyrins do interact with sGC, though they are poor activators, indicating that further optimization of their structure is required. 相似文献
58.
aneta Krl-Kiliska Dominika Kulig Ihar Yelkin Anna Zimoch-Korzycka ukasz Bobak Andrzej Jarmoluk 《International journal of molecular sciences》2021,22(9)
The aim of the study was to investigate the changes within the physicochemical properties of gelatin, carrageenan, and sodium alginate hydrosols prepared on the basis of micro-clustered (MC) water. The rheological parameters, contact angle and antioxidant activity of hydrosols were investigated. Moreover, the pH, oxidation–reduction potential (ORP) and electrical conductivity (EC) were measured. The hydrosols with MC water were characterized by a lower pH, decreased viscosity, a lower contact angle, and only slightly lower antioxidant activity than control samples. The results showed that hydrosol’s properties are significantly changed by MC water, which can lead to enhancement of its applicability but requires further investigation. 相似文献
59.
Grzegorz Karol Wagner Magdalena Jaszek Bernard Staniec Monika Prendecka Dominika Pigo Anna Belcarz Dawid Stefaniuk Anna Matuszewska Ewa Pietrykowska-Tudruj Mirosaw Zagaja 《International journal of molecular sciences》2021,22(9)
Six new water extracts (E1–E6) were obtained from nest carton produced by jet black ants Lasius fuliginosus and tested for their biochemical and bioactive properties, including antioxidative and anticancer effects. The present study demonstrated significant qualitative and quantitative differences in the content of individual biochemical constituents, as well as bioactive properties between the investigated samples. All tested extracts demonstrated antioxidant properties (determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods), and the highest antioxidative potential was recorded in extracts E1 and E2 (188.96 and 313.67 μg/mL of ascorbic acid equivalent for ABTS and 176.42 and 202.66 μg/mL for DPPH reagent). Furthermore the six extracts exhibited strong inhibitory activity towards human melanoma cells of the A-375 CRL-1619 line in a dose-dependent manner. The most interesting chemopreventive activity was exhibited by extract E2, which inhibited the proliferation of A-375 cells to the greatest extent, while having a minimal effect on Vero cells. The effect on cancer cells has been confirmed using the Electric Cell-substrate Impedance Sensing (ECIS) technique. Significant impedance changes have been detected in A-375 and Vero cells following the administration of extract E2. The obtained results are really promising and constitute the basis for further research on the nest carton of jet black ant. 相似文献
60.
Dominika Kozon Prof. Piotr Bednarczyk Prof. Adam Szewczyk Prof. Dominik Jańczewski 《Chembiochem : a European journal of chemical biology》2021,22(6):1020-1029
Amphiphilic antimicrobial polymers display activity against the outer bacterial cell membrane, triggering various physiological effects. We investigated the regulation of ion transport across the lipid bilayer to understand differences in biological activity for a series of amphiphilic polymethyloxazoline – polyethyleneimine copolymers. The results confirmed that the tested structures were able to increase the permeability of the lipid bilayer (LB) membrane or its rupture. Black lipid membrane (BLM) experiments show that the triggered conductance profile and its character is strongly correlated with the polymer structure and zeta potential. The polymer exhibiting the highest antimicrobial activity promotes ion transport by using a unique mechanism and step-like characteristics with well-defined discreet openings and closings. The molecule was incorporated into the membrane in a reproducible way, and the observed channel-like activity could be responsible for the antibacterial activity of this molecule. 相似文献