液相直接沉淀法制备纳米SnO2

在单因素实验和Box-Behnken实验设计基础上,利用响应面分析法,对影响纳米SnO2收率的工艺条件进行优化研究,验证实验显示,得到的最优条件能够很好地符合预测值。通过单因素和响应面分析实验,得到了纳米SnO2最优工艺参数:水解温度80℃、水解时间44 min、滴加浓度为0.84 mol/L的SnCl4.5H2O 27 mL反应,产物在700℃下煅烧180 min。SnO2平均收率可达99.77%,平均粒径为23.6 nm。取得的最优工艺条件可以很好地用于纳米SnO2的生产,具有一定的理论与实用价值。     

特殊情况下如何做好竣工决算阶段的造价控制

通过具体的工程案例分析,叙述在采用平行承发包模式,且只有计价依据,没有清单报价的特殊情况下,如何进行竣工决算阶段造价控制的做法．     

LPG贮罐注水堵漏抢险工艺的探讨

讨论了LPG贮罐发生泄漏事故时采取的注水堵漏工艺。     

Cationic Effect of Ferrous Ions on Sulfide Capacity of CaO-FetO-Al2O3-SiO2 Slag System

Metallurgical and Materials Transactions B - The cationic effect of ferrous ions on the sulfide capacity of CaO-FetO-Al2O3-SiO2 slags was studied from the viewpoint of the ionic structure in the...     

State of the Art: The Immunomodulatory Role of MSCs for Osteoarthritis

Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it has recently been understood as a low-grade chronic inflammatory process that could promote symptoms and accelerate the progression of OA. Current treatment strategies, including corticosteroid injections, have no impact on the OA disease progression. Mesenchymal stem cells (MSCs) based therapy seem to be in the spotlight as a disease-modifying treatment because this strategy provides enlarged anti-inflammatory and chondroprotective effects. Currently, bone marrow, adipose derived, synovium-derived, and Wharton’s jelly-derived MSCs are the most widely used types of MSCs in the cartilage engineering. MSCs exert immunomodulatory, immunosuppressive, antiapoptotic, and chondrogenic effects mainly by paracrine effect. Because MSCs disappear from the tissue quickly after administration, recently, MSCs-derived exosomes received the focus for the next-generation treatment strategy for OA. MSCs-derived exosomes contain a variety of miRNAs. Exosomal miRNAs have a critical role in cartilage regeneration by immunomodulatory function such as promoting chondrocyte proliferation, matrix secretion, and subsiding inflammation. In the future, a personalized exosome can be packaged with ideal miRNA and proteins for chondrogenesis by enriching techniques. In addition, the target specific exosomes could be a gamechanger for OA. However, we should consider the off-target side effects due to multiple gene targets of miRNA.     

Liutex identification on hairpin vortex structures in a channel based on msfle and moving-PIV

The spatiotemporal evolution of hairpin vortex structures in a fully developed turbulent boundary layer is investigated qualitatively and quantitatively by usin...     

Thermal Contact Resistance between Aero Engine Compressor Blade and Flexible Fixture

In the process of two-pass micro plasma arc welding of titanium alloy sheet,based on the thermal contact resistance theory,a three-dimensional transient heat tr...     

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Due to its essential role in cellular processes, actin is a common target for bacterial toxins. One such toxin, TccC3, is an effector domain of the ABC-toxin produced by entomopathogenic bacteria of Photorhabdus spp. Unlike other actin-targeting toxins, TccC3 uniquely ADP-ribosylates actin at Thr-148, resulting in the formation of actin aggregates and inhibition of phagocytosis. It has been shown that the fully modified F-actin is resistant to depolymerization by cofilin and gelsolin, but their effects on partially modified actin were not explored. We found that only F-actin unprotected by tropomyosin is the physiological TccC3 substrate. Yet, ADP-ribosylated G-actin can be produced upon cofilin-accelerated F-actin depolymerization, which was only mildly inhibited in partially modified actin. The affinity of TccC3-ADP-ribosylated G-actin for profilin and thymosin-β4 was weakened moderately but sufficiently to potentiate spontaneous polymerization in their presence. Interestingly, the Arp2/3-mediated nucleation was also potentiated by T148-ADP-ribosylation. Notably, even partially modified actin showed reduced bundling by plastins and α-actinin. In agreement with the role of these and other tandem calponin-homology domain actin organizers in the assembly of the cortical actin network, TccC3 induced intense membrane blebbing in cultured cells. Overall, our data suggest that TccC3 imposes a complex action on the cytoskeleton by affecting F-actin nucleation, recycling, and interaction with actin-binding proteins involved in the integration of actin filaments with each other and cellular elements.     

关于高等数学教学改革的几点意见

对现行高等数学教学中存在的一些突出问题,提出改革措施.