Optimal number of redundant channels for a digital communication system

In many critical applications of digital systems, fault tolerance has been an essential architectural attribute for achieving high reliability. This paper considers the problem of determining the optimal number of redundant channels in a digital communication system. The expected system cost is obtained. We determine the number of redundant channels minimizing the expected system cost. A numerical example illustrates the techniques.     

Optimal learning for patterns classification in RBF networks

The proposed modifying of the structure of the radial basis function (RBF) network by introducing the weight matrix to the input layer (in contrast to the direct connection of the input to the hidden layer of a conventional RBF) so that the training space in the RBF network is adaptively separated by the resultant decision boundaries and class regions is reported. The training of this weight matrix is carried out as for a single-layer perceptron together with the clustering process. In this way the network is capable of dealing with complicated problems, which have a high degree of interference in the training data, and achieves a higher classification rate over the current classifiers using RBF     

The phosphorylation state of translation initiation factors is regulated developmentally and following heat shock in wheat

Several translation initiation factors in mammals and yeast are regulated by phosphorylation. The phosphorylation state of these factors is subject to alteration during development, environmental stress (heat shock, starvation, or heme deprivation), or viral infection. The phosphorylation state and the effect of changes in phosphorylation of the translation initiation factors of higher plants have not been previously investigated. We have determined the isoelectric states for the wheat translation initiation factors eIF-4A, eIF-4B, eIF-4F, eIF-iso4F, and eIF-2 and the poly(A)-binding protein in the seed, during germination, and following heat shock of wheat seedlings using two-dimensional gel electrophoresis and Western analysis. We found that the developmentally induced changes in isoelectric state observed during germination or the stress-induced changes were consistent with changes in phosphorylation. Treatment of the phosphorylated forms of the factors with phosphatases confirmed that the nature of the modification was due to phosphorylation. The isoelectric states of eIF-4B, eIF-4F (eIF-4E, p26), eIF-iso4F (eIF-iso4E, p28), and eIF-2alpha (p42) were altered during germination, suggesting that phosphorylation of these factors is developmentally regulated and correlates with the resumption of protein synthesis that occurs during germination. The phosphorylation of eIF-2beta (p38) or poly(A)-binding protein did not change either during germination or following a thermal stress. Only the phosphorylation state of two factors, eIF-4A and eIF-4B, changed following a heat shock, suggesting that plants may differ significantly from animals in the way in which their translational machinery is modified in response to a thermal stress.     

The chlamydial EUO gene encodes a histone H1-specific protease

Chlamydia trachomatis is an obligate intracellular pathogen, long recognized as an agent of blinding eye disease and more recently as a common sexually transmitted infection. Recently, two eukaryotic histone H1-like proteins, designated Hc1 and Hc2, have been identified in Chlamydia. Expression of Hc1 in recombinant Escherichia coli produces chromatin condensation similar to nucleoid condensation observed late in the parasite's own life cycle. In contrast, chromatin decondensation, observed during the early life cycle, accompanies down-regulation and nondetection of Hc1 and Hc2 among internalized organisms. We reasoned that the early upstream open reading frame (EUO) gene product might play a role in Hc1 degradation and nucleoid decondensation since it is expressed very early in the chlamydial life cycle. To explore this possibility, we fused the EUO coding region between amino acids 4 and 177 from C. trachomatis serovar Lz with glutathione S-transferase (GST) and examined the effects of fusion protein on Hc1 in vitro. The purified fusion protein was able to digest Hc1 completely within 1 h at 37 degrees C. However, GST alone exhibited no Hc1-specific proteolytic activity. The chlamydial EUO-GST gene product also cleaves very-lysine-rich calf thymus histone H1 and chicken erythrocyte histone H5 but displays no measurable activity towards core histones H2A, H2B, H3, and H4 or chlamydial RNA polymerase alpha-subunit. This proteolytic activity appears sensitive to the serine protease inhibitor 4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride (AEBSF) and aspartic protease inhibitor pepstatin but resistant to high temperature and other broad-spectrum protease inhibitors. The proteolytic activity specified by the EUO-GST fusion product selectively digested the C-terminal portion of chlamydial Hc1, the domain involved in DNA binding, while leaving the N terminus intact. At a molar equivalent ratio of 1:1 between Hc1 and DNA, the EUO gene product cleaves Hc1 complexed to DNA and this cleavage appears sufficient to initiate dissociation of DNA-Hc1 complexes. However, at a higher molar equivalent ratio of Hc1/DNA (10:1), there is partial protection conferred upon Hc1 to an extent that prevents dissociation of DNA-Hc1 complexes.     

Reliability analysis of k-out-of-n systems with partially repairable multi-state components

In some environments the components might not fail fully, but can lead to degradation and the efficiency of the system may decreases. However, the degraded components can be restored back through a proper repair mechanism. In this paper, we present a model to perform reliability analysis of k-out-of-n systems assuming that components are subjected to three states such as good, degraded, and catastrophic failure. We also present expressions for reliability and mean time to failure (MTTF) of k-out-of-n systems. Simple reliability and MTTF expressions for the triple-modular redundant (TMR) system, and numerical examples are also presented in this study.     

Primary water stress corrosion cracking inspection ranking scheme for alloy 600 components

The Palisades nuclear plant has developed a comprehensive inspection program to support safe, reliable, and cost-effective operation of all Alloy 600 nozzles and safe ends in the primary coolant system (PCS). As a part of the Palisades Alloy 600 Project, an inspection prioritization scheme was developed to help the plant focus its resources on high-risk components and plan appropriate inspection activities for the other components. The inspection prioritization scheme is based on the susceptibility of the components to primary water stress corrosion cracking (PWSCC), component failure consequences, component leak detectability and component radiation exposure. The scheme provides a simple, systematic and technical base for selecting Alloy 600 components for inspection. The scheme, however, could be used to develop an inspection schedule or to select the highest priority components for mitigation or replacement.     

A new approach for development of quadruped robot based on biological concepts

This paper proposes the design and development results of a new quadruped robot. The proposed new quadruped robot has a couple of advantages of flexible locomotion. The quadruped robot is designed and modeled based on a new concept that is the structure model with three segments of quadruped legs. New leg configuration with the simplified operation of four hip actuators is introduced. The posture of the new quadruped robot is more similar to the posture of dog than that of the previous quadruped robots. The objective of this paper is to develop a quadruped robot, which can walk and run in a trot gait with a simple PID controller. Numerical simulation and experimental results are shown to prove the locomotion performance of the proposed controller for the proposed quadruped robot.     

Significant Improvement in Activity and Stability of Pt/TiO2 Catalyst for Water Gas Shift Reaction Via Controlling the Amount of Na Addition

Na promoted Pt/TiO₂ catalysts have been studied under high severity, near equilibrium, conditions for use as a single stage WGS catalyst. Addition of 3 wt% Na to a 1 wt% Pt/TiO₂ catalyst has been found to improve water gas shift activity significantly compared to Pt/TiO₂, Pt/CeO₂, and Pt–Re/TiO₂ catalysts. This catalyst is stable when the reaction temperature is higher than 250 °C. Deactivation occurred when the reaction temperature was lower than 250 °C, however, returning the temperature to higher than 250 °C fully recovered activity. TEM observations revealed that addition of Na inhibited Pt particle sintering. These results suggest that Na promoted Pt/TiO₂ is a promising single stage water gas shift catalyst for small scale hydrogen production.