Defining a complex intervention: The development of demarcation criteria for “meditation”.

The authors used a 5-round Delphi study with a panel of 7 experts in meditation research to achieve agreement on a set of criteria for a working definition of “meditation” for use in a comprehensive systematic review of the therapeutic use of meditation. Participants agreed that essential to a meditation practice is its use of (a) a defined technique, (b) logic relaxation, and (c) a self-induced state. Participants also agreed that a meditation practice may (d) involve a state of psychophysical relaxation somewhere in the process; (e) use a self-focus skill or anchor; (f) involve an altered state/mode of consciousness, mystic experience, enlightenment or suspension of logical thought processes; (g) be embedded in a religious/spiritual/philosophical context; or (h) involve an experience of mental silence. The results of this study provide insight into the challenges faced by researchers who want to demarcate meditative practices from nonmeditative practices, and they describe an approach to this problem that may prove useful for researchers trying to operationalize meditation in the context of comparative research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interpersonal psychotherapy for co-occurring depression and chronic pain.

Up to 37% of individuals experience chronic pain during their lifetimes. Approximately one fourth of primary care patients with chronic pain also meet criteria for major depression. Many of these individuals fail to receive psychotherapy or other treatment for their depression; moreover, when they do, physical pain is often not addressed directly. Women, socioeconomically disadvantaged individuals, African Americans, and Latinos all report higher rates of pain and depression compared with other groups. This article describes a version of interpersonal psychotherapy tailored for patients with comorbid depression and chronic pain, interpersonal psychotherapy for depression and pain (IPT-P). IPT-P potentially could be delivered to many patient populations in a range of clinical settings, but this article focuses on its delivery within primary care settings for socioeconomically disadvantaged women. Adaptations include a brief 8-session protocol that incorporates strategies for anticipating barriers to psychotherapy, accepting patients' conceptualization of their difficulties, encouraging patients to consider the impact of their pain on their roles and relationships, emphasizing self-care, incorporating pain management techniques, and flexible scheduling. In addition, IPT-P is designed as an adjunct to usual medical pain treatment, and seeks to engage non–treatment-seeking patients in psychotherapy by focusing on accessibility and relevance of the intervention to concerns common among patients with pain. Identifying patients with comorbid depression and chronic pain and offering IPT-P as a treatment option have the potential to improve clinical outcomes for individuals with depression and chronic pain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The virtual production simulation platform: from collaborative distributed simulation to integrated visual analysis

Computational simulations are used for the optimization of production processes in order to significantly reduce the need for costly experimental optimization approaches. Yet individual simulations can rarely describe more than a single production step. A set of simulations has to be coupled to each other to form a contiguous representation of a process chain. Eventually, simulated results have to be analyzed by domain experts to gather insight from the preformed computations. In this paper, we propose an IT infrastructure and software tools that aim at a rather non-intrusive way of coupling resources and domain expert’s knowledge to enable the collaborative setup, execution and analysis of distributed simulation chains. We illustrate the approach in the domain of materials processing. Beyond means originating from the domain of GRID computing for resource management, a data integration component assures semantic data integrity between the simulation steps and stores simulation data in an application independent way. Thus, we can transform this data into native formats for each simulation tool, and finally into a format that allows for contiguous visualizations and an intuitive, comprehensive analysis of complete simulated process chains.     

Design and implementation of multipattern generators in analog VLSI

In recent years, computational biologists have shown through simulation that small neural networks with fixed connectivity are capable of producing multiple output rhythms in response to transient inputs. It is believed that such networks may play a key role in certain biological behaviors such as dynamic gait control. In this paper, we present a novel method for designing continuous-time recurrent neural networks (CTRNNs) that contain multiple embedded limit cycles, and we show that it is possible to switch the networks between these embedded limit cycles with simple transient inputs. We also describe the design and testing of a fully integrated four-neuron CTRNN chip that is used to implement the neural network pattern generators. We provide two example multipattern generators and show that the measured waveforms from the chip agree well with numerical simulations.     

Cloning, expression, and characterization of a DNA binding domain of gpNu1, a phage lambda DNA packaging protein

Terminase is an enzyme from bacteriophage lambda that is required for insertion of the viral genome into an empty pro-capsid. This enzyme is composed of the viral proteins gpNu1 (20.4 kDa) and gpA (73.3 kDa) in a holoenzyme complex. Current models for terminase assembly onto DNA suggest that gpNu1 binds to three repeating elements within a region of the lambda genome known as cosB which, in turn, stimulates the assembly of a gpA dimer at the cosN subsite. This prenicking complex is the first of several stable nucleoprotein intermediates required for DNA packaging. We have noted a hydrophobic region within the primary amino acid sequence of the terminase gpNu1 subunit and hypothesized that this region constitutes a protein-protein interaction domain required for cooperative assembly at cosB and that is also responsible for the observed aggregation behavior of the isolated protein. We therefore constructed a mutant of gpNu1 in which this hydrophobic "domain" has been deleted in order to test these hypotheses. The deletion mutant protein, gpNu1DeltaK, is fully soluble and, unlike full-length protein, shows no tendency toward aggregation; However, the protein is a dimer under all experimental conditions examined as determined by gel permeation and sedimentation equilibrium analysis. The truncated protein is folded with evidence of secondary and tertiary structural elements by circular dichroism and NMR spectroscopy. While physical and biological assays demonstrate that gpNu1DeltaK does not interact with the terminase gpA subunit, the deletion mutant binds with specificity to cos-containing DNA. We have thus constructed a deletion mutant of the phage lambda terminase gpNu1 subunit which constitutes a highly soluble DNA binding domain of the protein. We further propose that the hydrophobic amino acids found between Lys100 and Pro141 define a self-association domain that is required for the assembly of stable nucleoprotein packaging complexes and that the C-terminal tail of the protein defines a distinct gpA-binding site that is responsible for terminase holoenzyme formation.     

Personal hypothesis testing: The role of consistency and self-schema.

We report the results of two experiments that examined the way individuals test hypotheses about themselves. Both experiments were based on the work of Snyder (e.g., Snyder, 1981; Snyder & Skrypnek, 1981), which suggests that individuals have a confirmatory bias when testing hypotheses about others and about themselves. In Experiment 1, we examined the extent to which this bias toward confirmation persists when a negative (e.g., depression) or nonconsistent (not consistent with the individual's evaluation of him- or herself) personal hypothesis is tested. Results suggest that the negative or positive nature of a personal hypothesis does not directly influence the way individuals test their hypothesis. However, the way individuals tested personal hypotheses was influenced by hypothesis consistency. In Experiment 2, we examined the relation of a cognitive schematic variable (i.e., vulnerability for depression) and hypothesis testing. Results suggest that vulnerability is related to the way individuals test a personal hypothesis about depression. Vulnerable, low-depression participants were confirmatory when testing a depression hypothesis, whereas nonvulnerable, low-depression participants were disconfirmatory. We discuss implications for counseling and future directions for research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender differences in altruistic reputation: Are they artifactual?

Tested the notion that observed sex differences in children's altruistic reputations that favor girls are due to sex-biased items found in commonly used peer-assessment measures. A gender-fair assessment of altruistic reputation was attempted by including items that were empirically derived examples of masculine, feminine, and gender-neutral prosocial behaviors. These items were based on prosocial incidents reported by 65 5th graders. 123 additional 5th graders were asked to respond to the new items by nominating 2 classmates most likely to engage in prosocial behavior or by indicating which sex was most likely to perform the behaviors. Results show that, overall, females were judged to be more altruistic than males. However, endorsement differed across item content: Males were selected more often for masculine items and females more often for feminine and sex-neutral items. In general, males endorsed males for helpful behaviors and females endorsed females. The gender-rating form of the test produced responses more closely related to the empirically based item-gender-content classes than did the peer-nomination form. (18 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Wärmeübertragung in dissoziierenden Gasen bei schneller und gehemmter Gleichgewichtseinstellung

Stoff- und Transporteigenschaften von dissoziierenden Oasen: Spezifische Wärme, Wärmeleitzahl, Enthalpie, Viskosität, Diffusionskoeffizient. Aufstellung von Grenzschicht-Differentialgleichungen dissoziierender Gase für die Wärmeübertragung bei schneller Gleichgewichtseinstellung. Versuche zur Wärmeübertragung bei schneller Gleichgewichtseinstellung am N₂O₄–NO₂-Gemisch und deren Ergebnisse. Wärmeübertragung bei gehemmter Gleichgewichtseinstellung mit fallendem Druck. Ergebnisse für natürliche und erzwungene Konvektion am horizontalen Zylinder.