Absorbable polymer stent technologies for vascular regeneration

Stents are structural implants with widespread clinical use in vascular intervention to re‐open stenotic vessels for the treatment of coronary artery disease and peripheral arterial occlusive disease. Apart from their mechanical function, current drug‐eluting stents (DES) utilize local drug delivery from a drug‐incorporated permanent polymer coating to prevent in‐stent restenosis. This delayed closure of the stented vessel is considered one of the major limitations of conventional bare metal stents (BMS). The long‐term safety of DES, however, is still under debate, with reported cases of delayed healing, late thrombosis and hypersensitivity demanding further evolution in this field. A promising approach to circumvent the limitations of first generation DES is the application of degradable polymer coatings in second generation DES, and fully absorbable polymer stents. From a materials and engineering perspective, this paper provides a mini‐review of current clinically relevant DES technology and recent advancements in the development of stents from degradable polymeric materials as an alternative to permanent BMS and DES. This review, includes work on degradable stents and coatings based on blends of polylactic acid and the microbially‐produced poly(4‐hydroxybutyrate). Copyright © 2009 Society of Chemical Industry     

Konzept zur Maßstabsübertragung beim Suspendieren im Rührbehälter

Concept for Scale-up on Suspension in a Stirred Tank. The relationships derived for the suspension of solids in a propeller loop can be applied to corresponding processes in a stirred tank by means of analogy considerations. Accordingly, the ratio of stirrer power to slip power of laminar flow state is inversely proportional to the vessel diameter. In contrast, the power ratio remains constant in turbulent flow. There is a pronounced transition range between these two limiting states. The author's own experimental studies performed over a wide range of Re numbers for the recycling flow confirm this relationship. The observations presented explain why numerous authors have determined scale-up rules lying between these two extremes. The experiments shows that the power input for suspension is always significantly greater than the slip power. Under otherwise identical conditions, the necessary stirrer power is smaller by a factor of three for a propeller stirrer than for a disk impeller. The suspension of small solids concentrations can also be approximated by the flow model presented. The somewhat different physical relations valid in this case are substantiated by the author's experiments. The model also provided information relevant to scale-up when the particle properties are unknown. This is demontrated for an example in a 21 m³ vessel.