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81.
EJ Velthuis-te Wierik H van den Berg JA Weststrate KH van het Hof C de Graaf 《Canadian Metallurgical Quarterly》1996,50(4):214-219
Plasma levels of fibrinogen, factor VIIc and prothrombin fragment F1 + 2, a marker of thrombin generation in vivo, were studied in 68 subjects with serum total cholesterol (TC) levels between 135 and 349 mg/dl but without clinical evidence of cardiovascular disease and other atherosclerotic risk factors. F1 + 2 plasma levels were directly correlated with TC (p < 0.0004), low-density lipoprotein cholesterol (LDL-C; p < 0.0018) and factor VIIc (p < 0.024). Thirty-five subjects with TC greater than 249 mg/dl (median value of the whole group) showed higher levels of F1 + 2 (p < 0.0001) and fibrinogen (p < 0.0015) than those with TC lower than 249 mg/dl. In subjects with TC > 249 mg/dl and F1 + 2 > 1.2 nM (median value of the whole group), a cholesterol-lowering drug (simvastatin) was able to reduce F1 + 2 (p < 0.009) as well as TC and LDL-C. This study shows a relationship between serum cholesterol and the rate of thrombin generation supporting the hypothesis that a hypercoagulable state may occur in hypercholesterolemic subjects before the onset of clinical evidence of atherosclerotic cardiovascular disease. 相似文献
82.
S Knecht M Deppe EB Ringelstein M Wirtz H Lohmann B Dr?ger T Huber H Henningsen 《Canadian Metallurgical Quarterly》1998,29(6):1155-1159
BACKGROUND AND PURPOSE: Since functional transcranial Doppler ultrasonography (fTCD) allows convenient and fully automated quantification of language lateralization, it seems ideal for longitudinal studies of perfusion changes during deterioration as well as recovery of language functions. However, during serial examinations, the technical, stochastic, and physiological variabilities of cerebral blood flow velocities (CBFV) have to be considered. Therefore, before fTCD is accepted as a tool for evaluation of changes in lateralization in the diseased state, its reliability in healthy subjects needs to be determined. METHODS: We performed fTCD during a word generation task based on a previously validated technique with automated calculation of the averaged CBFV differences in the middle cerebral arteries providing an index of lateralization (LI). RESULTS: (1) The accuracy of the LI as assessed by the confidence interval was better than 1% of the mean hemispheric difference. (2) On repeated examination, LIs obtained from 10 subjects showed a high test-retest reproducibility (Pearson product moment correlation coefficient r = 0.95, P < 0.0001). (3) On 10 repeated assessments of LI in the same subject, no practice effects were detected. CONCLUSIONS: Functional TCD is a suitable and very robust tool for the longitudinal quantitative measurement of cerebral language lateralization. 相似文献
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86.
Cristiane Vieira Helm Alicia de Francisco Salete Aparecida Gaziola Ricardo Francisco Fornazier Georgia Bertoni Pompeu Ricardo Antunes Azevedo 《Food Biotechnology》2005,18(3):327-341
Barley (Hordeum vulgare L.) has had an important impact on human nutrition. Hull-less barley is a genetically improved type that has been widely used in recent years. Six Brazilian hull-less barley varieties (IAC-IBON 214-82; IAC 8612-421; IAC 8501-31; IAC 8501-12; IAPAR 39-ACUMAI; IAC 8501-22) were analyzed for storage protein constituents, amino acid contents, and similarity among the hull-less barley varieties. Albumins, globulins, prolamins I and II, and glutelins were extracted and separated by SDS-PAGE. The total protein amino acid contents of the flour were also determined for each variety by TLC and HPLC. Variations in intensity and appearance and disappearance of protein bands were observed among the varieties suggesting genetic variability. However, the amino acid profile did not indicate any major variations in the amino acid concentrations. The high lysine and threonine total concentrations detected in the seeds of the hull-less barley varieties encouraged an investigation into the regulation of amino acid metabolism and storage protein synthesis. 相似文献
87.
Bei der Model Driven Architecture (MDA) bilden Modelle die zentralen Elemente des Softwareentwicklungsprozesses. Ziel ist es, plattformspezifische Modelle möglichst automatisiert aus plattformunabhängigen Modellen abzuleiten. Dadurch soll der Aufwand der Softwareentwicklung verringert und die Adaptierung an neue Technologien erleichtert werden.*Vorschläge an Prof. Dr. Frank Puppe oder Dieter Steinbauer Alle „Aktuellen Schlagwörter“ seit 1988 finden Sie unter: www.ai-wuerzburg.de/as 相似文献
88.
Dr. V. Recina Dr. D. Lundström B. Karlsson 《Metallurgical and Materials Transactions A》2002,33(9):2869-2881
The influence of chemical composition on the microstructure of the γ-titanium aluminide alloy Ti-48Al-2W-0.5Si (at. pct) and the accompanying tensile, low-cycle fatigue, and creep properties
has been evaluated. The study showed that small variations in chemical composition and casting procedures resulted in considerable
variations in the microstructure, yielding vastly different mechanical properties. Low contents of aluminum and tungsten led
to a coarse-grained lamellar (γ/α
2) microstructure with high creep resistance. A composition close to the nominal one produced a duplex (γ+γ/α
2) structure with favorable strength, ductility, and low-cycle fatigue properties. By controlling the solidification and cooling
rates at casting, a pseudoduplex (PS-DP) microstructure with a unique combination of high strength and high fatigue and creep
resistance can be obtained. These unique properties can be explained by the diffuse boundaries between the relatively small
γ grains and the neighboring lamellar colonies, combined with semicoherent interfaces between the γ and α
2 phases. At tensile and low-cycle fatigue loading, these boundaries act like high-angle boundaries, producing a virtually
fine-grained material promoting strength, whereas at creep loading, grain-boundary sliding is hindered in the semicoherent
interfaces leading to high creep resistance. 相似文献
89.
Dr. H. -J. Dobner 《Computing》1987,38(3):209-218
This article describes a newly developed and implemented method for computing guaranteed errorbounds for the solution of hyperbolic initial value problems. The basic concepts—modified fixed point theorems and approximated operators—allow an a posteriori error-estimation automatically. Therefore, no a priori knowledge of Lipschitz constants, monotonicity properties or additional error analysis is necessary. 相似文献
90.
We describe a method for computing solutions of multi-point boundary value problems, where the polychotomic structure of the underlying solution space is specifically exploited. After the system is integrated in a multiple shooting way, the resulting linear system is solved by a special decoupling algorithm that takes into account the fact that the dichotomy on each interval is potentially different (in contrast to the two point case). A number of examples sustains the theory. 相似文献