Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 under the dose of 100 mg/kg increased the signal intensity of NOFe2+(DETC)2 complex, while EGb 761 at 200 mg/kg showed an effect of decreasing the signal intensity of NOFe2+(DETC)2 complex. EGb 761 inhibited the formation of TBARS, the release of CK, and mitigated the incidence of ventricular arrhythmias in a dose dependent way. Both l-arginine and SOD increased the signal intensity of NOFe2+(DETC)2 complex and inhibited the formation of TBARS, the leakage of CK and the incidence of ventricular arrhythmia. NNA not only had no protective effects on myocardial injury, but also increased the incidence of reperfusion-induced arrhythmia. In conclusion, EGb 761 has cardiovascular protective effects by means of adjusting the level of NO and inhibiting oxygen free radicals induced lipid peroxidation in myocardial ischemia-reperfusion injury in vivo.     

Computation of nonlinear functionals in particle methods

We consider the numerical computation of nonlinear functionals of distribution functions approximated by point measures. Two methods are described and estimates for the speed of convergence as the number of points tends to infinity are given. Moreover, numerical results for the entropy functional are presented.     

Analysis of ink flow in a mimeograph printer based on the mechanics of fluid-filled poroelastic solids

Summary To understand some main ink flow mechanisms in a mimeograph printer, the continuum mechanics theory of fluid-saturated porous solids is applied to analyze the ink flow through screens and a printing master, which are modeled by a fluid-filled poroelastic single layer. The layer is assumed to be pressed by a press roller from below and to be subjected from above to the hydrodynamic lubrication pressure induced between a printing drum and an ink roller. Nonlinear elasticity of the layer and dependence of the permeability on its deformation are taken into account. The numerical results show some important results: e.g., squeezing-out of the ink from the layer by the layer compaction by the press roller plays an important role, especially for the case where the compression duration is small in comparison with the characteristic time of the ink-filled poroelastic layer.     

GRU-based capsule network with an improved loss for personnel performance prediction

Applied Intelligence - Personnel performance is a key factor to maintain core competitive advantages. Thus, predicting personnel future performance is a significant research domain in human...     

一种新的无线电高度表原位检测的高度模拟方法

针对目前对高度表进行原位检测的需求,设计了一种新的高度模拟方法;该方法的实现以ARM为核心,通过高度模拟电路产生各种需要的高度电压信号,从而达到高度模拟的目的,并且无需对机载高度表进行拆装,操作简单、快捷、可靠性较高;实验结果表明,这种方法的高度模拟精度较高,具有一定的实用价值和经济效益.     

A route to chaos in a nonlinear oscillator with delay

Summary The paper presents an analysis of the transition from regular to chaotic motion in a Van der Pol-Duffing's oscillator with delay after a Hopf bifurcation. The conditions for the occurrence of the Hopf bifurcation have been determined by means of the approximate method. For the parameters near the bifurcation point a computer simulation of the vibrating system had been performed and the evolution of the system from regular motion to chaos has been analysed at the decrease of the value of the dimensionless damping coefficient.With 2 Figures     

The incorporation of yield surface distortion into a unified constitutive model,part 2: Predictive capabilities

Summary The MATMOD-4V-DISTORTION model has been derived [1] with the intent of improving the MATMOD-4V model by adding the capability to predict distortions of small strain offset yield surfaces. This model is compared against a variety of experimental data to verify its behavior. Model simulations are compared with experimental data for proportional and nonproportional prestress histories and the effect of yield definition is also investigated. Finally, the same model which predicts a flattening of the yield surface in space is used to predict a rotation of the yield surface in ₁-₂ coordinates.With 9 Figures     

Stromdichte- und Magnetfeldverteilung bei einer Anordnung aus Platten und vielen parallelen Stromleitern

Übersicht Die vorliegende Arbeit befaßt sich mit der gesamten Stromdichte- und Magnetfeldverteilung in vielen flachen leitenden Platten konstanter Permeabilität, die bei einer Anordnung aus diesen Platten und vielen parallelen stromführenden Leitern angeordnet in mehreren Lagen entsteht. Unter Anwendung der Maxwellschen Differentialgleichungen und durch Einführung des Vektorpotentials werden allgemeine Gleichungen für die Komponenten der magnetischen Induktion im zweidimensionalen Feldraum aufgestellt. Die Stromdichteverteilung in den leitenden Platten, in denen Wirbelströme entstehen, wird aus dem Vektorpotential hergeleitet. Zunächst werden die Platten unendlich lang angenommen und die entsprechenden Gleichungen in Integralform aufgestellt, für deren Lösung die Gauss-Laguerresche Methode angewandt wird. Dann werden die Platten beiderseits durch Eisenwände begrenzt, womit die Gleichungen unter Berücksichtigung der Randbedingungen in Summenform ausgedrückt werden.

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Distribution of current and magnetic field density in flat conductive plates in an array composed from plates and many parallel conductors

Contents In the present research work the overall distribution of current and magnetic field density in many flat plates of constant magnetic permeability has been investigated, which applies to an array composed from the flat plates and many parallel conductors installed in many layers. Use of Maxwell's differential equations and vector potential results in general equations for the components of magnetic density in two dimensional field space. The distribution of current density in the conductive plates, where eddy currents are taken into account, is obtained from the vector potential. Initially the flat plates are considered being of infinite length, and with appropriate arrangement of the boundary conditions, the model applies to flat plates limited to both sides by iron partitions. Examples are given for both cases, where for the plates of infinite length the Gauss-Laguerre method is applied.

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Liste der Symbole A Vektorpotential - B Magnetische Induktion - I ₁ Stromstärke eines Leiters - N ₁ Anzahl der parallelen Leiter - N ₂ Anzahl der parallelen Platten - Permeabilität des Plattenmaterials - _r Relative Permeabilitätskonstante des Plattenmaterials - Leitfähigkeit - b Breite des Hauptstreukanals - i Stromdichte der Platten samt Wirbelströme - h ₁ Höhe der Leiter - a ₁ Breite der Leiterlagen - a Plattendicke - s Breite des Nebenstreukanals - c Abstand der letzten Platte von der Eisenwand - g Plattenhöhe - x, z, , Dimensionen - Q, K Integrationskonstanten - k ganze Zahl     

A combinatorial study of the rigidity of planar structures

Summary A combinatorial method is presented for examining the rigidity of planar structures. In this approach, an expansion process is used for the formation of a statically determinate substructure, known as a -tree of a structure. The algorithm of Lováz and Yemini, and the method of Sugihara are employed for the recognition of the elementary subgraphs, during this process.With 4 Figures     

Acoustic waves in solids with random cavities,II: Energy density considerations

Summary The propagation of acoustic plane and line-polarized waves in an isotropic solid containing random cavities is studied theoretically and experimentally. The effect of the cavities on the energy density and macroscopic propagation parameters of the acoustic waves is considered and the relationships between the cavities volume concentration, their average dynamic shape factor and the dynamic overall stiffness moduli of the solid are derived in the long wave approximation.