Reprocessing of Microcrystalline Cellulose Spheres with Low Drug Concentrations

Spherical dosage forms have been reported to be an efficient and effective method for delivering drugs into the body and controlling their dissolution rate. Substantial work has been conducted in these laboratories illustrating the advantages of microcrystalline cellulose-based spheres for these purposes. Through various methodologies, but most routinely the extrusion and marumerization technique, it has been determined by Funck, et al. that not more than 50% drug can be incorporated into a sphere formulation without the addition of other binders.

Because of the nature of the extrusion and marumerization manufacturing process, the type of drug being processed and the resultant particle size requirements of the spheres, the percent of spheres falling outside the desired particle size can range from between 3% and 20%. For this reason and the possibility of operator errors, our objective was to determine the parameters which needed monitoring when reprocessing was necessary.     

Numerical investigation of the convection of heat-emitting liquid reactor materials taking stratification into account

Conclusions The calculations for the different levels of volume heat release showed that the integral heat fluxes at the lateral and top surfaces are virtually independent of the scenario of convective flow. However, the maximum of the heat flux on the lateral surface in the homogeneous case is 1.5–1.6 times higher than the maximum heat flux in the stratified case. This could result in larger mechanical loads on the reactor vessel and therefore more stringent requirements on the cooling of the outer surface of the reactor vessel. Institute of Fast Reactors, Russian Academy of Sciences. Translated from Atomnaya énergiya, Vol. 76, No. 5, pp. 406–411, May, 1994.     

Determination of the intensity of emission of a radioactive contaminant from the ventilation pipes of a nuclear power plant

All-Union Scientific-Research Institute of Nuclear Power Plants NIIP. Translated from Atomnaya énergiya, Vol. 77, No. 5, pp. 392–402, November, 1994.     

Clonal analysis of peripheral blood lymphocytes from three patients with advanced neuroblastoma receiving recombinant interleukin-2 and interferon alpha

Cultures of both isolated and conjugated explants from early gastrulae of Bufo arenarum were prepared for a study of the development of ventral mesoderm. Only combinations including components of the deep ventral marginal zone and the animal pole successfully differentiated into blood cells (erythrocytes). Histological studies indicated that, while prospective mesodermal cells constituted the only source of such cells, prospective ectodermal cells provided the necessary stimulus for this kind of differentiation. Differentiated cultures, in which the tracer of cell-lineage fluorescein dextran amine was used to label these components, confirmed the above conclusions. These findings are discussed in the context of current concepts about the formation of mesoderm.     

Topical use of aprotinin in open heart operations

Among various pharmacological agents used to reduce bleeding after open-heart operations, high-dose aprotinin therapy seems most promising. However, its long-term effects are still obscure; there is almost always possibility of bypass graft occlusions produced by the hypercoagulable state induced by aprotinin in coronary bypass operations. Topical application of aprotinin into the pericardial cavity could prevent the adverse effects. Fifty patients were prospectively studied to evaluate the effects of topical aprotinin. One million KIU of aprotinin was poured into the pericardial cavity before closure of the sternotomy in group 1 (n = 25). Patients in group 2 (n = 25) served as controls. Total postoperative bleeding was significantly reduced in group 1 when compared with that of group 2 (722.7 +/- 230.8 versus 1,282.6 +/- 225.7 mL; p < 0.01). The use of banked donor blood products was significantly less in group 1 than in group 2 (0.33 +/- 0.67 versus 1.36 +/- 0.86 units; p < 0.01). These results show that topical use of aprotinin reduces post-operative blood loss and need for transfusion. It seems promising and warrants further studies to be done.     

Composition of lithium aluminoborosilicate glass and abrasive

The properties of glasses of the lithium-aluminoborosilicate system were investigated, namely, the density, spreadability, thermal expansion, and nature of crystallized phases at various temperatures. A crystal-optical analysis was conducted. The glasses were used to prepare abrasive compositions. Their strength properties were studied as a function of the composition of the glass binder and the regime of heat treatment.Translated from Steklo i Keramika, No. 3, pp. 27–30, March, 1996.     

Calculi with the greatest number

Translated from Kibernetika i Sistemnyi Analiz, No. 3, pp. 71–86, May–June, 1995.     

Cost-benefit analysis of power system reliability: two utility casestudies

There is an emerging recognition that utility investments and other decisions that affect electric service reliability should be explicitly evaluated on the basis of their cost and benefit implications. A cost-benefit approach that quantifies the reliability benefits of alternatives in terms of the reduction in costs resulting from unserved energy enables the evaluation of generation and transmission capacity additions on a consistent, economic basis. This approach has been applied to two utility case studies. In a case study for Pacific Gas and Electric Company, it was used to evaluate three options for maintaining reliability in a major load center-two involving local generation, and the third, a new 230 kV transmission connection. In a case study for Duke Power Company, the approach was used to evaluate alternative designs for proposed additions to a transmission station. This paper describes the methodology and presents the two utility studies