Characterization of allergoids from ovalbumin in vitro and in vivo

Several in vivo and in vitro methods for monitoring immunological properties of two allergoids obtained by formaldehyde treatment of ovalbumin (OA) were developed. The calculated molecular weight of allergoids was 80 kD (OA-F1) and 165 kD (OA-F2), respectively. The allergenic activity in vitro of allergoids in mast-cell histamine release assay was 1000 times lower than of OA. Both allergoids showed reduced ability to induce passive cutaneous anaphylaxis in the Sprague-Dawley rats or systemic anaphylaxis in Dunkin-Harley guinea-pigs. The ability of OA and allergoids to bind to the OA-specific IgE antibodies was measured in vivo by the inhibition of passive cutaneous anaphylaxis (PCA-inhibition). Allergoid binding to IgE was 51-66% lower than the native allergen. Moreover, the avidity of OA-specific IgG antibodies, measured by ELISA-inhibition, for allergoids and allergen was of the same order. Allergoids induced a different pattern of humoral immune response from that, induced by the native allergen. Thus, after immunization of BALB/c mouse, both allergoids induced a higher production of IgG and a lower production of IgE than OA, only OA-F2 induced a lower production of IgG1. The differences in the IgA response to the immunogens was not significant. Delayed hypersensitivity studies in the BALB/c mouse showed that allergoids were 5- to 12-times less effective in inducing a cell-mediated immune response than OA. The present study provides a battery of immunological methods for preclinical testing of modified allergens.     

A novel way to treat refractory waste: Sonication followed by wet oxidation (SONIWO)

The effectiveness of the hybrid system sonication followed by wet oxidation (SONIWO) to treat otherwise refractory waste has been demonstrated. In such a hybrid system homogeneous CuSO₄ catalyst was found to be very efficient.     

Cold forging and chemical heat treatment of the casing of the internal joint for VAZ cars

The technological process of cold forging applied for the first time in the production of the casing of the internal joint with races is described. The process operations of cold forging and the annealing and carburizing regimes for this part me described.     

Magnetization and rotation of MTG HTSC ring in magnetic field

The magnetization of a melt-texture growth (MTG) HTSC ring has been studied. It is shown that the magnetic field inside the ring is larger than the external field under a certain range of external magnetic fields. We have also investigated the magnetic field dependence of the response of a detective coil near a rotating superconducting ring. The responses of the MTG sample are different for different cooling methods.     

Variation of the creep limit and structure of a welded joint in PT-3V titanium alloy under the effect of cyclic loading. Report 2

Comparative analysis of the characteristics of amplitude-dependent internal friction (IF) was carried out to explain reasons leading to an increase of the creep limit of the butt welded joint in PT-3V titanium alloy (PT-2V filler material) after cyclic loading. IF was measured by the method of the direct torsional pendulum on cylindrical specimens representing the gage part of the specimens subjected to preliminary cyclic loading. The data were processed using the Granato-Lucke theory. The results show that the reduction of IF after cyclic loading took place as a result of an increase of the number and redistribution of pinning points of the dislocations. Consequently, the density of mobile dislocations decreases by 8% and the length of dislocation segments by 18%. These processes of stabilization of the structure were completed within 5·10 ⁴ cycles of preliminary loading. Stabilization of the dislocation structure of the material of the welded joint increases its creep limit.Translated from Problemy Prochnosti, No. 4, pp. 35–40, April, 1996.     

Increasing the interference immunity of broadband systems for measuring and transmitting information by utilizing nonlinear signal processing methods

A method is considered for increasing the immunity from interference of broadband systems for measuring and transmitting information. It is based on utilizing nonlinear methods to process spread-spectrum signals. The possibility is investigated of using a quasioptimal receiving device which can be implemented in practice. It is shown that the proposed method makes it possible to solve the rejection problem at the physical level. Translated from Izmeritel'naya Tekhnika, No. 11, pp. 13–15, November, 1996.     

Parametric inference for step-stress models

Applications of the additive accumulation of damages (AAD) or the accelerated failure time (AFT) and the proportional hazards (PH) models in accelerated life testing with step-stresses are discussed. A new model including AAD and PH models is proposed. It is more reasonable than the PH model and wider then the AAD model. Constructing the maximum likelihood function is discussed     

Experience in High-Temperature Thermomechanical Treatment with Helical Reduction in the Production of Axisymmetric Parts

Metal Science and Heat Treatment -