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排序方式: 共有1111条查询结果,搜索用时 15 毫秒
61.
Daniela Grimm Herbert Schulz Marcus Krüger Jos Luis Corts-Snchez Marcel Egli Armin Kraus Jayashree Sahana Thomas J. Corydon Ruth Hemmersbach Petra M. Wise Manfred Infanger Markus Wehland 《International journal of molecular sciences》2022,23(6)
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality. Therefore, groundbreaking research and innovations are necessary. Research in space under microgravity (µg) conditions is a novel approach with the potential to fight cancer and develop future cancer therapies. Space travel is accompanied by adverse effects on our health, and there is a need to counteract these health problems. On the cellular level, studies have shown that real (r-) and simulated (s-) µg impact survival, apoptosis, proliferation, migration, and adhesion as well as the cytoskeleton, the extracellular matrix, focal adhesion, and growth factors in cancer cells. Moreover, the µg-environment induces in vitro 3D tumor models (multicellular spheroids and organoids) with a high potential for preclinical drug targeting, cancer drug development, and studying the processes of cancer progression and metastasis on a molecular level. This review focuses on the effects of r- and s-µg on different types of cells deriving from thyroid, breast, lung, skin, and prostate cancer, as well as tumors of the gastrointestinal tract. In addition, we summarize the current knowledge of the impact of µg on cancerous stem cells. The information demonstrates that µg has become an important new technology for increasing current knowledge of cancer biology. 相似文献
62.
Synthesis and Retention Behaviour of Smectic 2,5-Diphenyl-pyrimidines The synthesis of 2-[4-n-alkylphenyl]-5-[4-n-alkoxy-phenyl]-pyrimidines 3 , as well as the gas chromatographic investigations concerning the retention behaviour of their smectic A, C, F and G modifications for the substituted benzenes are described. Starting from the calculated enthalpies of solution and activity coefficients the intermolecular interactions in the range of terminal groups are discussed. The polarity of the stationary phases is proved by their chemical structure and only by a small part corresponding structure of the mesophases. 相似文献
63.
Kollmann Immel Holdheide M. Antonoff H. Mayer-Wegelin Frey-Wyssling Eidmann Thiele J. S. Cammerer A. v. Wacek Klauditz Scheer A. Nowak Gumz Vorreiter Finkbeiner Müller Munds E. Becker A. Kraus Fessel Keylwerth A. Troche Graf B. Thunell Tiemann Bäseler 《Holz als Roh- und Werkstoff》1942,5(10):363-371
Ohne Zusammenfassung 相似文献
64.
65.
Karl Sauer Diemair E. Dinslage Kanitz Schwaibold Willy Lindner Haevecker Lehnartz E. Becker W. Schreiber Werner Hofmann Eduard Hofmann Steinbeck H. Süllmann Griebel Rudolf Abderhalden Lars Erlandsen Heyns O. v. Soden C. Steinhoff J. Großfeld Frey-Wyssling W. Sutthoff Bäurle Willy Lindner Ed. Rentz Bandow Gerards K. N. v. Kaulla O. v. Soden Maria Cicconi Pawletta Baars R. Grau Lerche Beckel O. Windhausen Felicitas Rolleri Jesser Karl Boresch R. W. Seuffert K. Müller Schloemer K. Höll Johannes Wolf Brüning Patzsch W. Ludorff 《European Food Research and Technology》1941,81(3):223-288
66.
v. Pohl R. Trendelenburg Zimmermann E. Brüche S. Nickel Zycha Liese Schulz Graf A. Troche T. Perkitny M. Lüdtke Frey-Wyssling K. Storch Otto Kratky A. v. Wacek Finkbeiner K. Storch Munds Paula Sarten Ernst Tschanter A. Kraus R. Lechner Schaile Thiele W. Küch Kräß Hengerer Kollmann A. Nowak 《Holz als Roh- und Werkstoff》1940,3(4):128-136
Ohne Zusammenfassung 相似文献
67.
R. Trendelenburg Botteri Schulz Zimmermann Schulz Gustav G. Klem Frey-Wyssling O. Kratky A. v. Wacek O. Kratky G. Becker Egner Graf B. Thunell M. Lüdtke S. Nickel A. Kraus Klar Finkbeiner Müller E. Becker Zimmermann v. Pohl Lechner Richard Huber L. Metz Thiele Schlüter Egner W. Wenhart Graf Kinberg Kraemer 《Holz als Roh- und Werkstoff》1940,3(5):165-174
Ohne Zusammenfassung 相似文献
68.
Hassan Elhadidy Jan Franc Eduard Belas Pavel Hlídek Pavel Moravec Roman Grill Pavel Hoschl 《Journal of Electronic Materials》2008,37(9):1219-1224
Thermoelectric effect spectroscopy and photoluminescence techniques were used to study the defect levels in samples from three
crystals of CdTe:In grown by the vertical gradient freeze method. The main goal of the investigation was to study defects,
which strongly trap charge carriers or act as recombination centers in order to eliminate them from the technological process.
The main difference among detecting and non-detecting samples was the absence of electron traps with a very high capture cross-section
and energy 0.6 eV to 0.7 eV, which act as lifetime killers even at low concentrations. Recently published ab initio calculations show a complex of Te antisite and Cd vacancy within this energy range. 相似文献
69.
Stella Vallejos Polona Umek Toni Stoycheva Fatima Annanouch Eduard Llobet Xavier Correig Patrizia De Marco Carla Bittencourt Chris Blackman 《Advanced functional materials》2013,23(10):1313-1322
Tungsten oxide nanostructures functionalized with gold or platinum NPs are synthesized and integrated, using a single‐step method via aerosol‐assisted chemical vapour deposition, onto micro‐electromechanical system (MEMS)‐based gas‐sensor platforms. This co‐deposition method is demonstrated to be an effective route to incorporate metal nanoparticles (NP) or combinations of metal NPs into nanostructured materials, resulting in an attractive way of tuning functionality in metal oxides (MOX). The results show variations in electronic and sensing properties of tungsten oxide according to the metal NPs introduced, which are used to discriminate effectively analytes (C2H5OH, H2, and CO) that are present in proton‐exchange fuel cells. Improved sensing characteristics, in particular to H2, are observed at 250 °C with Pt‐functionalized tungsten oxide films, whereas non‐functionalized tungsten oxide films show responses to low concentrations of CO at low temperatures. Differences in the sensing characteristics of these films are attributed to the different reactivities of metal NPs (Au and Pt), and to the degree of electronic interaction at the MOX/metal NP interface. The method presented in this work has advantages over other methods of integrating nanomaterials and devices, of having fewer processing steps, relatively low processing temperature, and no requirement for substrate pre‐treatment. 相似文献
70.
Michael Loughlin Eduard Polunovskiy Neill Taylor 《Fusion Engineering and Design》2012,87(5-6):646-651
The complexity of nuclear analysis on the design components of ITER is discussed. These analyses include the determination of several nuclear responses and it is shown that these results are not only relevant to the component under examination but have implications for the design of many other, often remote, systems. The contribution of nuclear analysis to the licensing process is discussed. An example is given of how this complexity means that the there is a large set of complementary analyses required to address the concerns of the licensing authorities. It also means that the nuclear analysis must be co-ordinated to ensure that the results are self-consistent and provide an integrated solution. 相似文献