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21.
22.
Azizul Haque Arabinda Das Supriti Samantaray Denise Matzelle Mollie Capone Gerald Wallace Aarti N. Husarik Saied Taheri Russel J. Reiter Abhay Varma Swapan K. Ray Naren L. Banik 《International journal of molecular sciences》2022,23(4)
Spinal cord injury (SCI) causes significant mortality and morbidity. Currently, no FDA-approved pharmacotherapy is available for treating SCI. Previously, low doses of estrogen (17β-estradiol, E2) were shown to improve the post-injury outcome in a rat SCI model. However, the range of associated side effects makes advocating its therapeutic use difficult. Therefore, this study aimed at investigating the therapeutic efficacy of Premarin (PRM) in SCI. PRM is an FDA-approved E2 (10%) formulation, which is used for hormone replacement therapy with minimal risk of serious side effects. The effects of PRM on SCI were examined by magnetic resonance imaging, immunofluorescent staining, and western blot analysis in a rat model. SCI animals treated with vehicle alone, PRM, E2 receptor antagonist (ICI), or PRM + ICI were graded in a blinded way for locomotor function by using the Basso–Beattie–Bresnahan (BBB) locomotor scale. PRM treatment for 7 days decreased post-SCI lesion volume and attenuated neuronal cell death, inflammation, and axonal damage. PRM also altered the balance of pro- and anti-apoptotic proteins in favor of cell survival and improved angiogenesis and microvascular growth. Increased expression of estrogen receptors (ERs) ERα and ERβ following PRM treatment and their inhibition by ER inhibitor indicated that the neuroprotection associated with PRM treatment might be E2-receptor mediated. The attenuation of glial activation with decreased inflammation and cell death, and increased angiogenesis by PRM led to improved functional outcome as determined by the BBB locomotor scale. These results suggest that PRM treatment has significant therapeutic implications for the improvement of post-SCI outcome. 相似文献
23.
Wei Meng Joshua D. Palmer Michael Siedow Saikh Jaharul Haque Arnab Chakravarti 《International journal of molecular sciences》2022,23(4)
Gliomas represent a wide spectrum of brain tumors characterized by their high invasiveness, resistance to chemoradiotherapy, and both intratumoral and intertumoral heterogeneity. Recent advances in transomics studies revealed that enormous abnormalities exist in different biological layers of glioma cells, which include genetic/epigenetic alterations, RNA expressions, protein expression/modifications, and metabolic pathways, which provide opportunities for development of novel targeted therapeutic agents for gliomas. Metabolic reprogramming is one of the hallmarks of cancer cells, as well as one of the oldest fields in cancer biology research. Altered cancer cell metabolism not only provides energy and metabolites to support tumor growth, but also mediates the resistance of tumor cells to antitumor therapies. The interactions between cancer metabolism and DNA repair pathways, and the enhancement of radiotherapy sensitivity and assessment of radiation response by modulation of glioma metabolism are discussed herein. 相似文献
24.
Andro Mondala Rafael Hernandez William Holmes Todd French Linda McFarland Darrell Sparks Monica Haque 《American Institute of Chemical Engineers》2013,59(11):4036-4044
The co‐fermentation of glucose and xylose by activated sludge microorganisms for the production of microbial oils for use as biodiesel feedstock was investigated. Various carbon sources at initial concentration of 60 g/L and C:N ratio 70:1 were investigated: xylose, glucose, and 2:1 and 1:2 (by mass) glucose/xylose mixtures. Oil accumulation ranged between 12 to 22% CDW, the highest of which was obtained when xylose was the sole substrate used. Kinetic modeling of the fermentation data showed that specific growth and oil accumulation rates were similar in all substrate types and the lipid coefficient ranged from 0.02 to 0.06 g/g of sugar consumed. The fatty acid methyl ester yield and composition of the lipids showed their suitability for conversion to biodiesel. Based on the results, lignocellulose sugars could be used as fermentation substrates by activated sludge microorganisms for enhancing the oil content of sewage sludge for its use as a sustainable biofuel feedstock source. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4036–4044, 2013 相似文献
25.
Isolation and identification of phosphate‐solubilizing microorganisms and distribution of orthophosphate in different seasons from sewage‐fed East Kolkata Wetland
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Subinoy Mondal Smaranya Haque Debajyoti Kundu Deblina Dutta Apurba Ratan Ghosh 《Lakes & Reservoirs: Research and Management》2018,23(3):261-270
This study focused on isolation and identification of possible phosphate‐solubilizing bacteria (PSB ) from the sewage‐fed East Kolkata Wetland (EKWL ), a prospective water resource for pisciculture. In addition, different limnological parameters have been correlated with orthophosphate and seasonal variations. PSB have been isolated in Pikovskaya medium and identified morphologically and biochemically and finally analysed by 16S rDNA gene sequence. Limnological studies involving temperature (potentiometric), pH (potentiometric), dissolved oxygen (iodometric), ammonia‐nitrogen (spectrophotometric) and orthophosphate (spectrophotometric) concentrations were conducted. The results of this study established the presence of Bacillus megaterium , a potential PSB in EKWL . The activity of B. megaterium is also supported by the seasonal orthophosphate variations. The changes in concentration of other limnological parameters were also prominent. The water quality parameters of temperature (r = 0.886), dissolved oxygen (r = 0.729) and ammonia‐nitrogen (r = 0.396) concentrations exhibited a positive correlation with orthophosphate and a negative correlation with pH (r = ?0.699). The B. megaterium obtained in this study, exhibited a significant alteration in regard to orthophosphate content and relationships with other factors. Further experiment on the soluble phosphorus solubilization potential of B. megaterium revealed the biological availability of phosphorus was increased by threefold after 120 hr of incubation, with the decreasing pH value, although the phytase activity was 0.419 U/ml. PSB have a vital function in plant nutrition in supplying phosphate, essential nutrients and its uptake results in appropriate functioning and metabolism of different aquatic plants and organisms. PSB are competent biofertilizer to amplify aquaculture production for sustainable development. 相似文献
26.
Md Hossain Ali Ismail Abustan Md Ashiqur Rahman Abu Ahmed Mokammel Haque 《Water Resources Management》2012,26(3):623-641
Water is essential for economic, social, and environmental development. Global water resources are vulnerable due to increasing
demand related to population growth, pollution potential, and climate change. Competition for water between different sectors
is increasing. To meet the increasing demand, the use of groundwater is increasing worldwide. In this paper, the water-table
dynamics of the north-eastern region of Bangladesh were studied using the MEKESENS software. This study reveals that the depth
to water-table (WT) of almost all the wells is declining slowly. In many cases, the depth will approximately double by the
year 2040, and almost all will double by 2060, if the present trend continues. If the decline of the water-table is allowed
to continue in the long run, the result could be a serious threat to the ecology and to the sustainability of food production,
which is vital for the nation’s food security. Therefore, necessary measures should be taken to sustain water resources and
thereby agricultural production. Demand-side management of water and the development of alternative surface water sources
seem to be viable strategies for the area. These strategies could be employed to reduce pressure on groundwater and thus maintain
the sustainability of the resource. 相似文献
27.
M. Grujicic G. Arakere W. C. Bell H. Marvi H. V. Yalavarthy B. Pandurangan I. Haque G. M. Fadel 《Journal of Materials Engineering and Performance》2010,19(3):301-313
The effect of materials processing- and component manufacturing-induced uncertainties in material properties and component
shape and size on the reliability of component performance is investigated. Specifically, reliability of a suspension system
component from a high-mobility multipurpose wheeled vehicle which typically can fail under low-cycle strain-based fatigue
conditions is analyzed. Toward that end, the most advanced reliability-based design optimization methods available in the
literature were combined with the present understanding of low-cycle fatigue durability and applied to the component in question.
This entailed intricate integration of several computational tools such as multibody vehicle dynamics, finite-element simulations,
and fatigue strain-life assessment/prediction techniques. The results obtained clearly revealed the importance of consideration
of material property uncertainties in attaining vehicle performance of critical structural components in complex systems (e.g.,
a vehicle). 相似文献
28.
E. S. Gurley N. Homaira H. Salje P. K. Ram R. Haque W. Petri J. Bresee W. J. Moss P. Breysse S. P. Luby E. Azziz‐Baumgartner 《Indoor air》2013,23(5):379-386
Approximately half of all children under two years of age in Bangladesh suffer from an acute lower respiratory infection (ALRI) each year. Exposure to indoor biomass smoke has been consistently associated with an increased risk of ALRI in young children. Our aim was to estimate the effect of indoor exposure to particulate matter (PM2.5) on the incidence of ALRI among children in a low‐income, urban community in Bangladesh. We followed 257 children through two years of age to determine their frequency of ALRI and measured the PM2.5 concentrations in their sleeping space. Poisson regression was used to estimate the association between ALRI and the number of hours per day that PM2.5 concentrations exceeded 100 μg/m3, adjusting for known confounders. Each hour that PM2.5 concentrations exceeded 100 μg/m3 was associated with a 7% increase in incidence of ALRI among children aged 0–11 months (adjusted incidence rate ratio (IRR) 1.07, 95% CI 1.01–1.14), but not in children 12–23 months old (adjusted IRR 1.00, 95% CI 0.92–1.09). Results from this study suggest that reducing indoor PM2.5 exposure could decrease the frequency of ALRI among infants, the children at highest risk of death from these infections. 相似文献
29.
The purpose of this study is to provide a detailed safety analysis of overall system and components in terms of their ability to provide optimum output from the irradiation of TeO2 in the central thimble of the 3 MW TRIGA MARK II research reactor at Atomic Energy Research Establishment (AERE), Savar, Dhaka, Bangladesh. It identifies safety issues relevant to 131I radioisotope production and ensures that safety analysis and design are consistent. It evaluates threats developed within the facility during the irradiation process and ultimately ensures establishment of in-core safety limits and conditions at all stages of 131I production. In-core irradiation safety not only ensures the safe operation of the reactor but also strengthens the production of radioisotopes (RI). This study attempts to review and modify all safety related events and aspects relating to RI production. The three-dimensional continuous energy Monte Carlo code MCNP is used to develop a versatile and accurate full-core model of the TRIGA core. The cross-section library and fission product inventory are generated by using NJOY and ORIGEN computer codes. The methodology to evaluate heat generation and other relevant parameters necessary to provide enough information for thermal hydraulic analysis are discussed. The neutron flux distribution inside the dry and water filled central thimble is determined in order to locate the highest neutron flux trapping position. The thermal hydraulic and safety analysis are performed by elaborate numerical analysis as well as by using GENGTC computer code. A mock-up facility has also been developed to supplement and verify the theoretically predicted results. The total energy generated during irradiation of 50 gm TeO2 sample in dry condition is found to be 113.84 w of which 75% energy is due to neutron heating and rest of the amount is from gamma heating. Around 11.28 w of heat energy is also generated in the quartz vial. When the total generated-heat transfer is considered through conduction and radiation mechanisms, the calculated temperature of 50 g of TeO2 reaches at 970 °C. Considering simultaneous heat transfer mechanisms, (conduction, radiation and convection) the calculated maximum temperature of the 50 g of TeO2 powder comes down at 680 °C. It may be pointed out that very high amount of heat is generated during the irradiation of TeO2 at 3 MW reactor power in dry condition which is nearly the melting point of TeO2 and may be termed as unsafe mode of irradiation. 相似文献
30.
Kimmons JE Dewey KG Haque E Chakraborty J Osendarp SJ Brown KH 《Food and nutrition bulletin》2004,25(3):228-238
This study used simple rapid-assessment techniques to test the feasibility of increasing the consumption of complementary foods by infants by asking mothers to increase meal quantity or frequency or by altering the viscosity/energy density of the food. The feasibility of using micronutrient supplements either added directly to food or administered as liquid drops was also examined. The study was conducted in rural Bangladesh and involved four separate short-term behavioral change trials. Depending on the trial, fieldworkers recruited 30 to 45 infants 6 to 12 months of age. Following recommendations to increase the amount of food provided to infants, the mean intakes from single meals increased from 40 +/- 23 g on day 1 to 64 +/- 30 g on day 7 (p < 0.05). In a second trial, the mean meal frequency increased from 2.2 +/- 1.3 on day 1 to 4.1 +/- 1.3 on day 7 (p < 0.05). Provision of high-energy-density diets, prepared by decreasing viscosity with alpha-amylase or by hand-mashing rice and dhal into a paste before feeding, increased single-meal energy consumption from 54 +/- 35 kcal to 79 +/- 52 kcal or 75 +/- 37 kcal (p < 0.05), respectively. Both types of micronutrient supplements were well accepted and used according to recommendations. In conclusion, it was possible to change short-term child-feeding behaviors to promote increased food intake, mealfrequency, energy density, and micronutrient consumption. Because each of these interventions lasted for only about 1 week, however, the long-term sustainability of these changes is not known. Moreover, the effect of increased feeding of complementary foods on intakes of breastmilk and total daily consumption of energy and nutrients requires further study. 相似文献