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Chronic pulmonary thromboembolism is an underdiagnosed condition with major morbidity and mortality. Over the past year and a half, we diagnosed 6 new cases of which 3 underwent successful, pulmonary thrombo-endarterectomy (2 in San Diego, 1 in Jerusalem). All recovered fully and returned to normal, active life. We conclude that pulmonary thrombo-endarterectomy is a viable option for patients with chronic pulmonary thromboembolism.  相似文献   
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In order to help keep readers up‐to‐date in the field, each issue of Progress in Photovoltaics will contain a list of recently published journal articles that most relevant to its aims and scope. This list is drawn from an extremely wide range of journals, including IEEE Journal of Photovoltaics, Solar Energy Materials and Solar Cells, Renewable Energy, Renewable and Sustainable Energy Reviews, Journal of Applied Physics, and Applied Physics Letters. To assist the reader, the list is separated into broad categories, but please note that these classifications are by no means strict. Also note that inclusion in the list is not an endorsement of a paper's quality. If you have any suggestions please email Ziv Hameiri at ziv.hameiri@unsw.edu.au  相似文献   
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Thrombin is the final protease produced in the clotting pathways. Thrombin has been used in the clinic more than six decades for topical hemostasis and wound management. In human plasma the half‐life of thrombin is shorter than 15 seconds due to close control by inhibitors. In order to stabilize thrombin, this enzyme was conjugated covalently and physically to γ‐Fe2O3 magnetic nanoparticles. The physical conjugation was accomplished through adsorption of thrombin to BSA coating on the nanoparticles. The coagulant activity of the covalently bound thrombin was significantly lower than that of the physically adsorbed thrombin. Leakage of the physically bound thrombin into PBS containing 4% HSA was negligible. The physical conjugation of thrombin onto the nanoparticles stabilized the thrombin against its major inhibitor antithrombin III and improved its storage stability. At optimal CaCl2 concentration, the clotting time by the bound thrombin is shorter than that of the free enzyme. This novel conjugated thrombin may be an efficient candidate for topical hemostasis and wound healing.  相似文献   
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Alzheimer’s disease (AD) is the most common form of dementia, but there is still no available treatment. Δ9-tetrahydrocannabinol (THC) is emerging as a promising therapeutic agent. Using THC in conventional high doses may have deleterious effects. Therefore, we propose to use an ultra-low dose of THC (ULD-THC). We previously published that a single injection of ULD-THC ameliorated cognitive functioning in several models of brain injuries as well as in naturally aging mice. Here, 5xFAD AD model mice received a single treatment of ULD-THC (0.002 mg/kg) after disease onset and were examined in two separate experiments for cognitive functions, neurotropic, and inflammatory factors in the hippocampus. We show that a single injection of ULD-THC alleviated cognitive impairments in 6- and 12-month-old 5xFAD mice. On the biochemical level, our results indicate an imbalance between the truncated TrkB receptor isoform and the full receptor, with AD mice showing a greater tendency to express the truncated receptor, and ULD-THC improved this imbalance. We also investigated the expression of three AD-related inflammatory markers and found an ameliorating effect of ULD-THC. The current research demonstrates for the first time the beneficial effects of a single ultra-low dose of THC in a mouse model of AD after disease onset.  相似文献   
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G protein-coupled receptors (GPCRs) are involved in a vast majority of signal transduction processes. Although they span the cell membrane, they have not been considered to be regulated by the membrane potential. Numerous studies over the last two decades have demonstrated that several GPCRs, including muscarinic, adrenergic, dopaminergic, and glutamatergic receptors, are voltage regulated. Following these observations, an effort was made to elucidate the molecular basis for this regulatory effect. In this review, we will describe the advances in understanding the voltage dependence of GPCRs, the suggested molecular mechanisms that underlie this phenomenon, and the possible physiological roles that it may play.  相似文献   
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Closing the feedback loop from coverage data to the stimuli generator is one of the main challenges in the verification process. Typically, verification engineers with deep domain knowledge manually prepare a set of stimuli generation directives for that purpose. Bayesian networks based CDG (coverage directed generation) systems have been successfully used to assist the process by automatically closing this feedback loop. However, constructing these CDG systems requires manual effort and a certain amount of domain knowledge from a machine learning specialist. We propose a new method that boosts coverage in the early stages of the verification process with minimal effort, namely a fully automatic construction of a CDG system that requires no domain knowledge. Experimental results on a real-life cross-product coverage model demonstrate the efficiency of the proposed method.  相似文献   
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Unification grammars are known to be Turing-equivalent; given a grammar G and a word w, it is undecidable whether w L(G). In order to ensure decidability, several constraints on grammars, commonly known as off-line parsability (OLP), were suggested, such that the recognition problem is decidable for grammars which satisfy OLP. An open question is whether it is decidable if a given grammar satisfies OLP. In this paper we investigate various definitions of OLP and discuss their interrelations, proving that some of the OLP variants are indeed undecidable. We then present a novel, decidable OLP constraint which is more liberal than the existing decidable ones.  相似文献   
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