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JAKOVICS Andris PAVLOVS Sergejs BOSNYAKS Dmitrijs SPITANS Sergejs BAAKE Egbert NACKE Bernard 《钢铁研究学报(英文版)》2012,(Z2):749-753
Low frequency oscillations of temperature field in the industrial induction channel furnace(ICF)with symmetrical and widened channel branches as well as different iron yoke positions are obtained using Large Eddy Simulation(LES)approach.The application of k-co Shear Stress Transport(SST)turbulence model for computations of ICF with typical clogging shapes shows their influence on temperature and induced Joule heat power distributions,which are to be precise in LES study. 相似文献
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Mandy Gruijs Carolien Zeelen Tessa Hellingman Jasper Smit Frank J. Borm Geert Kazemier Chris Dickhoff Idris Bahce Joop de Langen Egbert F. Smit Koen J. Hartemink Marjolein van Egmond 《International journal of molecular sciences》2023,24(1)
Circulating tumor cells (CTCs) have been detected in many patients with different solid malignancies. It has been reported that presence of CTCs correlates with worse survival in patients with multiple types of cancer. Several techniques have been developed to detect CTCs in liquid biopsies. Currently, the only method for CTC detection that is approved by the Food and Drug Administration is CellSearch. Due to low abundance of CTCs in certain cancer types and in early stages of disease, its clinical application is currently limited to metastatic colorectal cancer, breast cancer and prostate cancer. Therefore, we aimed to develop a new method for the detection of CTCs using the Attune NxT—a flow cytometry-based application that was specifically developed to detect rare events in biological samples without the need for enrichment. When healthy donor blood samples were spiked with variable amounts of different EpCAM+EGFR+ tumor cell lines, recovery yield was on average 75%. The detection range was between 1000 and 10 cells per sample. Cell morphology was confirmed with the Attune CytPix. Analysis of blood samples from metastatic colorectal cancer patients, as well as lung cancer patients, demonstrated that increased EpCAM+EGFR+ events were detected in more than half of the patient samples. However, most of these cells showed no (tumor) cell-like morphology. Notably, CellSearch analysis of blood samples from a subset of colorectal cancer patients did not detect CTCs either, suggesting that these blood samples were negative for CTCs. Therefore, we anticipate that the Attune NxT is not superior to CellSearch in detection of low amounts of CTCs, although handling and analysis of samples is easier. Moreover, morphological confirmation is essential to distinguish between CTCs and false positive events. 相似文献
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Special applications of fluorinated organic compounds 总被引:1,自引:0,他引:1
The applications of fluorinated organic compounds (FOCs) as finishing agent for fabrics, components of extinguishing agents, electroplating bathes, lubricating oils, oxygen carriers in blood substitutes have been discussed. Recent achievements in methods of the fluorination and general principles of the synthesis of useful perfluorinated organic compounds are given as well. 相似文献
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Pile Spacing Effects on Lateral Pile Group Behavior: Load Tests 总被引:2,自引:0,他引:2
Kyle M. Rollins Ryan J. Olsen Jeffery J. Egbert Derek H. Jensen Kimball G. Olsen Brian H. Garrett 《Canadian Metallurgical Quarterly》2006,132(10):1262-1271
To investigate group interaction effects as a function of pile spacing, full-scale cyclic lateral load tests were performed on pile groups in stiff clay spaced at 3.3, 4.4, and 5.65 pile diameters in the direction of loading with as many as five rows of piles. Group interaction effects decreased considerably as pile spacing increased from 3.3 to 5.65D. Lateral resistance was a function of row location in the group, rather than location within a row. For a given deflection, the leading (first) row piles carried the greatest load, while the second and third row piles carried successively smaller loads. Fourth and fifth row piles carried about the same load as the third row piles. For a given load, the maximum bending moments in the trailing row piles were greater than those in the lead row, but these effects decreased as spacing increased. Cyclic loading reduced the peak load by about 15% after 15 cycles; however, distribution of load within the pile group was essentially the same as at the peak load. Gaps significantly reduced resistance for small deflections. 相似文献
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Monte Carlo rendering algorithms generally rely on some form of importance sampling to evaluate the measurement equation. Most of these importance sampling methods only take local information into account, however, so the actual importance function used may not closely resemble the light distribution in the scene. In this paper, we present Table‐driven Adaptive Importance Sampling (TAIS), a sampling technique that augments existing importance functions with tabular importance maps that direct sampling towards undersampled regions of path space. The importance maps are constructed lazily, relying on information gathered during the course of sampling. During sampling the importance maps act either in parallel with or as a preprocess to existing importance sampling methods. We show that our adaptive importance maps can be effective at reducing variance in a number of rendering situations. 相似文献
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Jeffrey S. Whiting Jonathan Dinerstein Parris K. Egbert Dan Ventura 《Computational Intelligence》2010,26(2):142-159
Cognitive and behavioral models have become popular methods for creating autonomous self‐animating characters. Creating these models present the following challenges: (1) creating a cognitive or behavioral model is a time‐intensive and complex process that must be done by an expert programmer and (2) the models are created to solve a specific problem in a given environment and because of their specific nature cannot be easily reused. Combining existing models together would allow an animator, without the need for a programmer, to create new characters in less time and to leverage each model's strengths, resulting in an increase in the character's performance and in the creation of new behaviors and animations. This article provides a framework that can aggregate existing behavioral and cognitive models into an ensemble. An animator has only to rate how appropriately a character performs in a set of scenarios and the system then uses machine learning to determine how the character should act given the current situation. Empirical results from multiple case studies validate the approach. 相似文献
40.
JD Dalto KV Johnson RM Gardner VJ Spuhler L Egbert 《Canadian Metallurgical Quarterly》1997,14(3):151-154
SUMMARY: lymph node involvement in renal cell carcinoma is factor of very poor prognosis. In a series of 55 node-positive patients, 33 (60%) had simultaneous renal vein or vena cava invasion and 32 (58.2%) had metastases. Gross lymph node involvement was found in 39 patients (70.9%). Patients without venous invasion or metastasis may have a prolonged survival. In this group, those with microscopic nodal involvement can be cured, as the 10 and 15-year the actuarial survival rate is 54.5% Formal lymphadenectomy might have played a role in these results. Surgery can be performed when vein invasion is present without metastasis, but the prognosis is generally poor. Survival does not seem to be influenced by surgery when metastasis is present, regardless of the vein status. 相似文献