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排序方式: 共有416条查询结果,搜索用时 140 毫秒
131.
Polina Tikhonova Iulia Pavlova Ekaterina Isaakova Vladimir Tsvetkov Alexandra Bogomazova Tatjana Vedekhina Artem V. Luzhin Rinat Sultanov Vjacheslav Severov Ksenia Klimina Omar L. Kantidze Galina Pozmogova Maria Lagarkova Anna Varizhuk 《International journal of molecular sciences》2021,22(13)
G-quadruplex (G4) sites in the human genome frequently colocalize with CCCTC-binding factor (CTCF)-bound sites in CpG islands (CGIs). We aimed to clarify the role of G4s in CTCF positioning. Molecular modeling data suggested direct interactions, so we performed in vitro binding assays with quadruplex-forming sequences from CGIs in the human genome. G4s bound CTCF with Kd values similar to that of the control duplex, while respective i-motifs exhibited no affinity for CTCF. Using ChIP-qPCR assays, we showed that G4-stabilizing ligands enhance CTCF occupancy at a G4-prone site in STAT3 gene. In view of the reportedly increased CTCF affinity for hypomethylated DNA, we next questioned whether G4s also facilitate CTCF recruitment to CGIs via protecting CpG sites from methylation. Bioinformatics analysis of previously published data argued against such a possibility. Finally, we questioned whether G4s facilitate CTCF recruitment by affecting chromatin structure. We showed that three architectural chromatin proteins of the high mobility group colocalize with G4s in the genome and recognize parallel-stranded or mixed-topology G4s in vitro. One of such proteins, HMGN3, contributes to the association between G4s and CTCF according to our bioinformatics analysis. These findings support both direct and indirect roles of G4s in CTCF recruitment. 相似文献
132.
When Russia's housing allowance programme, the country's first means‐tested programme, was introduced in 1994, it was truly innovative. However, there were difficulties from the start, many arising from the division of authority for setting programme parameters among different levels of government and the potential for variation in the treatment of similar households in different cities. In 1996, the programme's original simple basis for benefit determination was seriously impaired by the introduction of different principles for very low‐income households. Moreover, local governments have exhibited a willingness to vary benefits from year‐to‐year, depending on political and budgetary considerations. The analysis presented here documents the impact of these variations on participation rates in a sample of Russian cities. Large inequities are obviously present in the treatment of similar households from city to city. Indeed, it is questionable whether the programme as currently configured is fulfilling the social safety net function envisioned for it in the original legislation. 相似文献
133.
Shishatskaya EI Voinova ON Goreva AV Mogilnaya OA Volova TG 《Journal of materials science. Materials in medicine》2008,19(6):2493-2502
Microspheres have been prepared from the resorbable linear polyester of β-hydroxybutyric acid (polyhydroxybutyrate, PHB) by
the solvent evaporation technique and investigated in vitro and in vivo. Biocompatibility of the microspheres has been proved
in tests in the culture of mouse fibroblast cell line NIH 3T3 and in experiments on intramuscular implantation of the microspheres
to Wistar rats for 3 months. Tissue response to the implantation of polymeric microspheres has been found to consist in a
mild inflammatory reaction, pronounced macrophage infiltration that increases over time, involving mono- and poly-nuclear
foreign body giant cells that resorb the polymeric matrix. No fibrous capsules were formed around polymeric microparticles;
neither necrosis nor any other adverse morphological changes and tissue transformation in response to the implantation of
the PHB microparticles were recorded. The results of the study suggest that polyhydroxybutyrate is a good candidate for fabricating
prolonged-action drugs in the form of microparticles intended for intramuscular injection. 相似文献
134.
The primary objectives of the housing reforms in the Russian Federation were to reduce the balance of the state housing stock by privatisation and to raise rental payments in order to permit the market to achieve a more efficient utilisation of the housing stock by allocating available housing to those with effective housing demand. Part of these objectives also included improving the quality of maintenance in state housing by breaking up the monopolies of state maintenance firms and replacing them with private firms procured through competitive bidding procedures. Moscow, in particular, has been a forerunner in implementing housing reform policies, including shifting from state maintenance firms to contracted private ones. Using Moscow and other Russian cities as illustrations for reforms in maintenance and managementbrings to light the benefits of private maintenance and also problems which must be overcome, not only throughout Russia but in nearly all the countries of the formerSoviet bloc. This paper evaluates the institutional changes of maintenance and sources of funding for maintenance in Moscow during the reforms; it shows evidence of improved quality of housing maintenance through the use of contracted private firms; and providesa general overview of competitive maintenance and condominium formation throughout Russia. 相似文献
135.
Raman scattering characterization of CVD graphite films 总被引:1,自引:0,他引:1
Alexander N. Obraztsov Anastasiya V. Tyurnina Ekaterina A. Obraztsova Alexey A. Zolotukhin Binghai Liu Kok-Chung Chin Andrew T.S. Wee 《Carbon》2008,46(6):963-968
Raman spectroscopic study has been performed for thin graphite films grown on nickel substrates by chemical vapor deposition from a mixture of hydrogen and methane activated by a direct current discharge. Depending on the growth conditions, the CVD films are composed of graphene layers parallel to the substrate surface or of plate-like crystallites with the predominant orientation of their graphene layers perpendicular to the substrate surface. A comparison of the Raman spectra for the CVD films and for the highly oriented pyrolytic graphite has been performed. The mechanisms governing the Raman scattering process in the films are discussed. An important role of a double resonance mechanism in the Raman spectra of these graphite-based materials has been revealed. The Raman band positions and intensities and their dependence on excitation wavelength confirm a high degree of the structural order in the CVD graphite films. 相似文献
136.
Kirmayer S Aharon E Dovgolevsky E Kalina M Frey GL 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2007,365(1855):1489-1508
Lamellar nanocomposites based on semiconducting polymers incorporated into layered inorganic matrices are prepared by the co-assembly of organic and inorganic precursors. Semiconducting polymer-incorporated silica is prepared by introducing the semiconducting polymers into a tetrahydrofuran (THF)/water homogeneous sol solution containing silica precursor species and a surface-active agent. Semiconducting polymer-incorporated MoS(2) and SnS(2) are prepared by Li intercalation into the inorganic compound, exfoliation and restack in the presence of the semiconducting polymer. All lamellar nanocomposite films are organized in domains aligned parallel to the substrate surface plane. The incorporated polymers maintain their semiconducting properties, as evident from their optical absorption and photoluminescence spectra. The optoelectronic properties of the nanocomposites depend on the properties of both the inorganic host and the incorporated guest polymer as demonstrated by integrating the nanocomposite films into light-emitting diodes. Devices based on polymer-incorporated silica and polymer-incorporated MoS(2) show no diode behaviour and no light emission due to the insulating and metallic properties of the silica and MoS(2) hosts. In contrast, diode performance and electroluminescence are obtained from devices based on semiconducting polymer-incorporated semiconducting SnS(2), demonstrating that judicious selection of the composite components in combination with the optimization of material synthesis conditions allows new hierarchical structures to be tailored for electronic and optoelectronic applications. 相似文献
137.
Skorb EV Fix D Shchukin DG Möhwald H Sviridov DV Mousa R Wanderka N Schäferhans J Pazos-Pérez N Fery A Andreeva DV 《Nanoscale》2011,3(3):985-993
A novel sonochemical method for formation of mesoporous metal sponges is developed. Systematic investigation of ultrasound effects on various types of metal particles reveals the cavitation-induced oxidation of metal surface and etching of metal matrix as main factors in the ultrasound-driven metal modification. Beyond the specific examples, the findings provide guidelines for expansion of the concept towards a broad variety of metal systems and allow development of the sonochemical approaches to manipulation of the metal surface and inner structure. 相似文献
138.
Irina I. Marinaite Mikhail Yu. Semenov Yulia V. Semenova Ekaterina A. Zimnik 《Polycyclic Aromatic Compounds》2016,36(2):169-181
Polyciclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants in urban atmosphere. Several PAHs are known carcinogens or are the precursors to carcinogenic daughter compounds. Understanding the contributions of various PAH emission sources is critical to appropriately managing PAH levels in the environment. The sources of PAHs to urban snowpack in Shelekhov city, Eastern Siberia, characterized by extremely high levels of PAH accumulation in snow were determined by using end-member mixing approach. The best potential to distinguish PAH emission sources is exhibited by ratios of PAH pairs of the principal mass 228, 252, and 276. The ratios of PAH pairs were used as tracers of end-member PAH sources. The contributions of sources were calculated using systems of linear equations. The results obtained using ratios of PAH pairs were compared with those obtained using molecular diagnostic ratios. It was shown that the results obtained using diagnostic ratios as tracers are less reliable than the results obtained using the ratios of the sums of PAHs. 相似文献
139.
Dicho Stoyanov Stratiev Ivelina K. Shishkova Ekaterina Nikolaychuk Ilshat M. Sharafutdinov Anife Vely Magdalena Mitkova 《Petroleum Science and Technology》2016,34(9):860-865
Five empirical methods toestimate the content of aromatic, naphthenic, and paraffinic carbon and hydrogen content and the bulk properties were tested for prediction of aromatic structures content of 95 vacuum gas oils. The density demonstrated the highest correlation with the aromatic structures content among all other studied bulk properties and empirical parameters. The aromatic structures content could be predicted by a second order power law dependence on density with accuracy commensurable with the reproducibility of SARA analysis. The poly-nuclear aromatic structures content was also found to depend on the density and can be expressed by a linear function. 相似文献
140.
Dicho Stoyanov Stratiev Ivelina K. Shishkova Ekaterina Nikolaychuk Ilshat M. Sharafutdinov Ivan Stoyanov Chavdarov Radoslava Nikolova 《Petroleum Science and Technology》2016,34(7):652-658
Eight vacuum gas oils (VGOs) having different hydrocarbon composition and different distillation characteristics were cracked in a laboratory fluid catalytic cracking (FCC) advanced cracking equipment (ACE) unit. The experimental results showed that FCC VGO feedstock reactivity correlates with the content of saturates plus light aromatics, and with the content of nitrogen. The FCC gasoline olefin content was found to depend on T50% and saturate content of the FCC VGO feedstock. The results from a commercial FCC unit that processes a hydrotreated straight-run VGO and a VGO from ebullated bed residue H-Oil hydrocracker confirmed the results from the laboratory FCC ACE unit showing that reducing T50% and increasing saturate content of the FCC feedstock leads to a reduction of the FCC gasoline content. 相似文献