Measurement of DNA damage after exposure to 2450 MHz electromagnetic radiation

Recent reports suggest that exposure to 2450 MHz electromagnetic radiation causes DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) in cells of rat brain irradiated in vivo (Lai and Singh, Bioelectromagnetics 16, 207-210, 1995; Int. J. Radiat. Biol. 69, 513-521, 1996). Therefore, we endeavored to determine if exposure of cultured mammalian cells in vitro to 2450 MHz radiation causes DNA damage. The alkaline comet assay (single-cell gel electrophoresis), which is reportedly the most sensitive method to assay DNA damage in individual cells, was used to measure DNA damage after in vitro 2450 MHz irradiation. Exponentially growing U87MG and C3H 10T1/2 cells were exposed to 2450 MHz continuous-wave (CW) radiation in specially designed radial transmission lines (RTLs) that provided relatively uniform microwave exposure. Specific absorption rates (SARs) were calculated to be 0.7 and 1.9 W/kg. Temperatures in the RTLs were measured in real time and were maintained at 37 +/- 0.3 degrees C. Every experiment included sham exposure(s) in an RTL. Cells were irradiated for 2 h, 2 h followed by a 4-h incubation at 37 degrees C in an incubator, 4 h and 24 h. After these treatments samples were subjected to the alkaline comet assay as described by Olive et al. (Exp. Cell Res. 198, 259-267, 1992). Images of comets were digitized and analyzed using a PC-based image analysis system, and the "normalized comet moment" and "comet length" were determined. No significant differences were observed between the test group and the controls after exposure to 2450 MHz CW irradiation. Thus 2450 MHz irradiation does not appear to cause DNA damage in cultured mammalian cells under these exposure conditions as measured by this assay.     

Three-dimensional extension of non-linear shell formulation based on the enhanced assumed strain concept

Conventional shell formulations, such as 3- or 5-parameter theories or even 6-parameter theories including the thickness change as extra parameter, require a condensation of the constitutive law in order to avoid a significant error due to the assumption of a linear displacement field across the thickness. This means that the normal stress in thickness direction has to either vanish or be constant. In general, these extra constraints cannot be satisfied explicitly or they Sead to elaborate strain expressions. The main objective of the present study is to introduce directly a complete 3-D constitutive law without modification. Therefore, a 7-parameter theory is utilized which includes a linear varying thickness stretch as extra variable allowing also large strain effects. In order to preserve the basic features of a displacement formulation the extra strain term is incorporated via the enhanced assumed strain concept recently proposed by Simo and Rifai to improve the performance of finite elements. Since the extra strain parameter can be eliminated on the element level after discretization, the formulation preserves the formal structure of a 6-parameter shell theory. The resulting hybrid-mixed shell formulation is applied to large deformation problems with hyperelasticity, small and large strain plasticity.     

Exact subthreshold integration with continuous spike times in discrete-time neural network simulations

Very large networks of spiking neurons can be simulated efficiently in parallel under the constraint that spike times are bound to an equidistant time grid. Within this scheme, the subthreshold dynamics of a wide class of integrate-and-fire-type neuron models can be integrated exactly from one grid point to the next. However, the loss in accuracy caused by restricting spike times to the grid can have undesirable consequences, which has led to interest in interpolating spike times between the grid points to retrieve an adequate representation of network dynamics. We demonstrate that the exact integration scheme can be combined naturally with off-grid spike events found by interpolation. We show that by exploiting the existence of a minimal synaptic propagation delay, the need for a central event queue is removed, so that the precision of event-driven simulation on the level of single neurons is combined with the efficiency of time-driven global scheduling. Further, for neuron models with linear subthreshold dynamics, even local event queuing can be avoided, resulting in much greater efficiency on the single-neuron level. These ideas are exemplified by two implementations of a widely used neuron model. We present a measure for the efficiency of network simulations in terms of their integration error and show that for a wide range of input spike rates, the novel techniques we present are both more accurate and faster than standard techniques.     

Einfluß der Erstarrungsgeschwindigkeit auf die Gehalte der Legierungselemente an und vor der Phasengrenze flüssig-fest bei der Kristallisation verschiedener Legierungen der Systeme Kupfer—Mangan und Kupfer—Nickel

Modellvorstellungen zum Kristallisationsverlauf einphasig erstarrender Legierungen. Erörterung der Profile der chemischen Zusammensetzung im Kristall und, in der Schmelze bei zwei Geschwindigkeiten am Beispiel einer Kupfer-Mangan-Legierung. Einfluß der Erstarrungsgeschwindigkeit und des Ausgangsgehaltes auf die Gehalte des Legierungselementes an der Kristallisationsfront im Feststoff und in der Schmelze. Vergleich der eigenen Ergebnisse mit den Erstarrungsmodellen des Schrifttums.     

Antiferromagnetic, Neutral, and Superconducting Band in La2CuO4

The symmetry of the Bloch functions in the conduction band of tetragonal and orthorhombic La₂CuO₄ is examined for the existence of symmetry-adapted and optimally localizable (usual or spin-dependent) Wannier functions. It turns out that such Wannier functions do not exist in the tetragonal phase. In the orthorhombic phase, on the other hand, the Bloch functions can be unitarily transformed in three different ways into optimally localizable Wannier functions: they can be chosen to be adapted to each of the three phases observed in the pure or doped material, that is, to the antiferromagnetic phase, to the superconducting phase or to the phase evincing neither magnetism nor superconductivity. This group-theoretical result is proposed to be interpreted within a nonadiabatic extension of the Heisenberg model. Within this model, atomic-like states represented by these Wannier functions are responsible for the stability of each of the three phases. However, all the three atomic-like states cannot exist in the tetragonal phase, but are stabilized by the orthorhombic distortion of the crystal. A simple model is proposed which may explain the physical properties of La_2-x Sr _x CuO₄ as a function of the Sr concentration x.     

Optimization of lithographic masks using genetic algorithms

Due to its cost effectiveness and reliability, wet-chemical etching of silicon is still one of the key technologies for producing bulk-silicon microstructures. In this paper we present an approach for the design of advanced mask sets for anisotropic, wet-chemical etching of silicon. The optimization method of genetic algorithms is used to derive suitable masks for cases where geometrically calculated compensation structures fail. The underlying etch simulation is described as well as the optimization algorithm itself. Design tasks of current research projects are used as examples to illustrate the advantage of using the presented tool. Udo Triltsch was born in Bergisch Gladbach, Germany, in 1976. He received the Dipl.-Ing. degree for Mechanical Engineering from the Technical University of Braunschweig, Germany, in 2002. He is currently working towards his Ph.D. at the Institute for Microtechnology, Braunschweig, Germany. His research interests include: design methodology for MEMS, process simulation and knowledge management. Anurak Phataralaoha was born in Bangkok, Thailand, in 1973. He received the B. Eng. degree for Production Engineering from KMUTT, Thailand in 1995 and Dipl.-Ing. degree for Mechanical Engineering from Technical University of Clausthal, Germany in 2002. He is currently working towards his Ph.D. at the Institute for Microtechnology, Braunschweig, Germany. His research interests include: 3D-tactile sensors, micro machining for silicon, Tribological micro guide. Stephanus Büttgenbach obtained the Diploma and Ph.D. degrees in physics from the University of Bonn, Germany, in 1970 and 1973, respectively. From 1974 to 1985, he was with the Institute of Applied Physics of the University of Bonn, working on atomic and laser spectroscopy. In 1983, he was promoted to Professor of Physics. From 1977 to 1985, he was also a Scientific Associate at CERN in Geneva, Switzerland. In 1985, Dr. Büttgenbach joined the Hahn-Schickard-Society of Applied Research at Stuttgart as Head of the Department of Microtechnology, where he worked on micromechanics, laser microfabrication, and resonant sensors. From 1988 to 1991, he was the Founding Director of the Institute of Micro and Information Technology of the Hahn-Schickard-Society. In 1991, Dr. Büttgenbach became Professor of Microtechnology at the Technical University of Braunschweig. His current research centers on the development and application of micro sensors, micro actuators, and micro systems. Currently, he is Vice President of the Technical University of Braunschweig, where his areas of responsibility are research and technology transfer. Dima Straube was born in Berlin, Germany, in 1977. He received the Dipl.-Ing. degree for Civil Engineering from Technical University of Berlin, Germany, in 2002. He is currently working towards his Ph.D. at the Institute for Engineering Design, Braunschweig. His research interests include: design methodology for MEMS, computer aided design and tolerance management. Hans-Joachim Franke was born in Helmstedt, Germany, on February 14, 1944. He received his diploma in mechanical engineering (Dipl.-Ing.) from the Technical University of Braunschweig, Germany, in 1969. From 1969 to 1976 he was research assistant of Prof. Roth at the Institute for Engineering Design. In 1976 he received his Ph.D. degree in mechanical engineering. From 1976 to 1988 he had diverse executive positions at the KSB-AG in Frankenthal, Germany, a company, which produces pumps and valves. Since 1988 he has been the director of the Institute for Engineering Design of the Technical University of Braunschweig. His research interests are in the areas of design methodology, computer aided design and machine elements.     

Dichotic shadowing and selective attention to word meanings in schizophrenia.

The dichotic shadowing technique was employed with 24 newly admitted schizophrenics, 24 neurotic inpatients, and 24 healthy controls to locate sources of schizophrenic attentional deficit. The shadowed stimulus words in the relevant channel were always neutral, whereas the stimulus words in the irrelevant channel varied in each condition. The 4 conditions were (a) no distraction, (b) neutral words, (c) semantically similar words, and (d) affective words. All Ss performed better in the no-distraction condition compared to behavior in the other conditions, and better in the neutral vs the affective condition. Results indicate that decline in shadowing performance under distraction with affective word meaning is not a specific schizophrenic deficit. At the level of information processing studied, evidence was not found for attentional dysfunction in schizophrenia. Speculation on the sources of this discrepancy with other studies is presented, considering S groups tested and experimental control of attention switching. (42 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)