Modular software system for computer aided design of microsystems

A modular software system to assist engineers in designing microsystems is presented. The different modules support both the system and the component design and are linked with each other by a workflow management system. In particular, this paper presents the co-operation of the modules rumtopf, suzana and μ-toast. They assist the designer in the definition and validation of process sequences, the simulation of wet chemical etching of silicon and the tolerance management. The usage and usefulness of the presented software system is illustrated by an example showing the design of an acceleration sensor.     

Nachweis des konstruktiven Brandschutzes bei Stahlbetonstützen

Design of the Structural Fire Protection of Reinforced Concrete Columns It is necessary to explain the background of the structural fire design of reinforced concrete columns with a modified new firedesign‐table in the German standard DIN 4102. The limit condition of this table with a maximum 6 m length for rectangular columns and 5 m length for circular columns results often in very conservative reinforcements and dimensions of columns with smaller length. For these cases is proposed an extension of the firedesign‐ table. An example completes the paper.     

Flexural tensile tests with vertically perforated clay unit masonry with thin layer mortar / Biegezugversuche an Planziegelmauerwerk

As part of the EU project, INSYSME – INnovative SYStems for earthquake resistant Masonry Enclosures in reinforced concrete buildings – to optimise infill masonry the German project partners carried out an initial part of the project on flexural strength testing of high‐tech clay block masonry in accordance with DIN EN 1052‐2. In this a wide range of modern products was considered which at present is regulated in Germany by means of general building authority approvals. The test results show that the specifications for flexural tensile strength of high‐tech clay block masonry in DIN EN 1996 are very conservative in most cases.     

In vitro influence of D/L-lactic acid, sodium chloride and sodium nitrite on the infectivity of feline calicivirus and of ECHO virus as potential surrogates for foodborne viruses

The importance of foodborne viruses is increasingly recognized. Thus, the effect of commonly used food preservation methods on the infectivity of viruses is questioned. In this context, we investigated the antiviral properties of d,l-lactic acid, sodium chloride and sodium nitrite by in vitro studies. Two model viruses, Feline Calicivirus (FCV) and Enteric Cytophatic Human Orphan (ECHO) virus, were chosen for this study simulating important foodborne viruses (human noroviruses (NoV) and human enteroviruses, resp.). The model viruses were exposed to different solutions of d,l-lactic acid (0.1-0.4% w/w, pH 6.0-3.2), of sodium chloride (2-20%, w/v) and of sodium nitrite (100, 150 and 200 ppm) at 4 and 20 °C for a maximum of 7 days. Different results were obtained for the two viruses. ECHO virus was highly stable against d,l-lactic acid and sodium chloride when tested under all conditions. On the contrary, FCV showed less stability but was not effectively inactivated when exposed to low acid and high salt conditions at refrigeration temperatures (4 °C). FCV titers decreased more markedly at 20 °C than 4 °C in all experiments. Sodium nitrite did not show any effect on the inactivation of both viruses. The results indicate that acidification, salting or curing maybe insufficient for effective inactivation of foodborne viruses such as NoV or human enteroviruses during food processing. Thus, application of higher temperature during fermentation and ripening processes maybe more effective toward the inactivation kinetics of less stable viruses. Nevertheless, more studies are needed to examine the antiviral properties of these preserving agents on virus survival and inactivation kinetics in the complex food matrix.     

Facade systems with variable solar control using thermotropic polymer blends

Thermotropic layers integrated into glazing or transparent insulation systems reversibly reduce the total solar energy transmittance by becoming opaque when heated. Characteristics of both systems have been measured as a function of temperature and incidence angle, including the total solar energy transmittance for a thermotropic heat-mirror insulating glazing unit (IGU). Properties of complex thermotropic glazing systems have been simulated, starting from data characterising the thermotropic layer. The results show good agreement with measured data. A prototype system sample of a thermotropic heat-mirror IGU was integrated into an outdoor test facility and a thermotropic TEIF (transparent exterior insulation and finish) prototype system was installed into the facade of a demonstration house. Both systems have been monitored and showed the expected switching properties, resulting in the desired overheating protection. Computer simulations of the building integration of the thermotropic TEIF system have been performed, showing a strong dependence of the optimum switching temperature on the total solar and internal gains of the building.     

Neurological and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation

The aim of this study was to assess neurological, neuropsychological, and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation (BMT) who were recruited from a hematological outpatient clinic. In addition, risk factors for the development of late neurological complications were identified. In contrast to previous studies on autopsied patients, our study design provoked a bias away from increased neurological sequelae, because patients with early complications after BMT were excluded. Fifty-nine allogeneic patients and 7 autologous BMT patients underwent clinical examination, short neuropsychological testing, and cranial magnetic resonance imaging (MRI) 34 +/- 26 months after BMT. The pathological results of the neurological examination (abnormal 64%) and the MRI examination (white matter lesions, 54%; atrophy, 11%) were associated with the occurrence of chronic graft-versus-host disease (GvHD) evolving from acute GvHD, with corticosteroid therapy and with cyclosporine medication. Neuropsychological impairment (cognitive deficits, 37%) was associated with long-term cyclosporine medication and age. No influence of pre-BMT disease, BMT donor status, or the conditioning regimen was found. These results suggest that the frequent neurological abnormalities in long-term survivors of allogeneic BMT are associated with chronic GvHD and with the resulting immunosuppression as major risk factors.