Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP.     

一种基于混合决策树的调度知识获取算法*

提出了一种基于混合决策树的调度知识获取算法。将模拟退火算法融入遗传算法中,作为一种具有自适应变概率的变异操作,构成一种混合优化方法。利用这种混合方法求解在不同调度目标下制造系统的最优特征子集,同时确定控制决策树规模的最优参数;使用决策树评价混合方法中染色体编码的适应度,在得到不同调度目标下的最优特征子集和最优决策树参数后,生成调度知识。仿真实验结果表明,该算法在性能上优于其他算法。     

分布式PACS通信服务中间层构造方法研究

基于目前分布式PACS中存在的问题,提出一个通信服务中间层的构造方法,分别进行了基于设计模式通信框架的构造、DICOM图像互操作和分布式PACS可复用构件的研究.通信服务中间层的构造不仅提高了分布式PACS在网络异构环境中的可移植性、可扩展性以及相关QoS性能,还满足了PACS今后发展中提出的较高的互连互操作性的要求.     

Fabrication,Electrical and Photovoltaic Characterizations of SnSb2S4/n-Si Heterojunction

Silicon - An inexpensive spray pyrolysis technique was effectively used to form a p-type SnSb2S4 thin film on n-type Si wafer for the first time to produce SnSb2S4/n-Si heterojunction. The...     

Probing the Structural and Antimicrobial Study on a Sol–Gel Derived Velosef-Loaded Bioactive Calcium Magneso-Silicate Xerogel

Silicon - The nature of the opening silicate- based surface affects the chemical interaction, spectroscopic and antimicrobial efficiency. The aim of this approach was to evaluate the spectroscopic...     

Eco-friendly Geopolymer Composite Based on Non-heat-treated Phosphate Sludge Reinforced With Polypropylene Fibers

Silicon - Geopolymers produced with metakaolin (MK) and thermally untreated phosphate sludge (PS) are beneficial and environmentally advantageous materials, but their fragility limits its...     

Modern Template Design and Biological Evaluation of Cephradine-loaded Magnesium Calcium Silicate Nanocomposites as an Inhibitor for Nosocomial Bacteria in Biomedical Applications

Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel...     

Differential Subcellular Distribution of Cytokinins: How Does Membrane Transport Fit into the Big Picture?

Cytokinins are a class of phytohormones, signalling molecules specific to plants. They act as regulators of diverse physiological processes in complex signalling pathways. It is necessary for plants to continuously regulate cytokinin distribution among different organs, tissues, cells, and compartments. Such regulatory mechanisms include cytokinin biosynthesis, metabolic conversions and degradation, as well as cytokinin membrane transport. In our review, we aim to provide a thorough picture of the latter. We begin by summarizing cytokinin structures and physicochemical properties. Then, we revise the elementary thermodynamic and kinetic aspects of cytokinin membrane transport. Next, we review which membrane-bound carrier proteins and protein families recognize cytokinins as their substrates. Namely, we discuss the families of “equilibrative nucleoside transporters” and “purine permeases”, which translocate diverse purine-related compounds, and proteins AtPUP14, AtABCG14, AtAZG1, and AtAZG2, which are specific to cytokinins. We also address long-distance cytokinin transport. Putting all these pieces together, we finally discuss cytokinin distribution as a net result of these processes, diverse in their physicochemical nature but acting together to promote plant fitness.     

Preparation,Properties and Applications of the Hybrid Organic/Inorganic Nanocomposite Based on Nanoporous Carbon Matrix

Journal of Inorganic and Organometallic Polymers and Materials - Nanoporous carbon matrix was prepared by the sol–gel process from pyrogallol-formaldehyde (PF) mixtures in water using picric...