Novel bilayer electrospun poly(caprolactone)/ silk fibroin/ strontium carbonate fibrous nanocomposite membrane for guided bone regeneration

In this study, a thin layer with a thickness of about 120 μm of poly(caprolactone) (PCL) was fabricated by electrospinning method. Then, a fibrous nanocomposite composed of PCL/silk fibroin/strontium carbonate (PCL/SF/SrCO₃) was electrospun on the prepared layer. Then, they were characterized. The mechanical properties, water uptake, degradation rate, wettability, porosity, and bioactivity of the electrospun membrane were scrutinized in vitro. Cytotoxicity of the samples was assessed by using osteoblast-like cells (SAOS-2) and L929 fibroblasts. Moreover, the cell adhesion, alkaline phosphatase (ALP) activity, and calcium deposition through alizarin red staining were conducted. Results revealed that the bilayer structure doubled the optimum mechanical properties and the addition of SrCO₃ up to 15%–20% increased ALP activity, calcium deposition, and bioactivity. According to the results, the nanofibrous bilayer membrane containing 20 wt% SrCO₃, 20 wt% SF, and 60 wt% PCL was chosen as the optimum sample. Therefore, this membrane could be applied in guided bone regeneration (GBR).     

Environmental and Safety Aspects of Using Tritium in Fusion

Today most current fusion research and development activity is based on the expectation that the D–T reaction will be used for the first generation of fusion reactors. This mixture is the premier candidate for a fusion fuel on account of its outstanding energy gain. Fusion reactors will produce neither the problematic emissions now experienced from fossil-fuel-burning power plants nor the long-lived fission products and transuranic elements resulting from fission reactors. Even though, tritium is a radioactive isotope of hydrogen with 12.32 years half-life that exposes beta radiation. Although its specific activity is relatively weak but because of its gaseous state, it can leak easily from its container and contaminate its surrounding. In order to improving safety and reliability of fusion reactors, research groups jointly investigate radiation hazards resulting from the release of tritium and activation products during normal operations as well as accidental conditions. In this paper, some of the most significant safety and environmental aspects of tritium is briefly discussed.