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Elaheh Mortazavian Farid Abedin Dorkoosh 《Drug development and industrial pharmacy》2014,40(5):691-698
The purpose of this study is to optimize and characterize of chitosan buccal film for delivery of insulin nanoparticles that were prepared from thiolated dimethyl ethyl chitosan (DMEC-Cys). Insulin nanoparticles composed of chitosan and dimethyl ethyl chitosan (DMEC) were also prepared as control groups. The release of insulin from nanoparticles was studied in vitro in phosphate buffer solution (PBS) pH 7.4. Optimization of chitosan buccal films has been carried out by central composite design (CCD) response surface methodology. Independent variables were different amounts of chitosan and glycerol as mucoadhesive polymer and plasticizer, respectively. Tensile strength and bioadhesion force were considered as dependent variables. Ex vivo study was performed on excised rabbit buccal mucosa. Optimized insulin nanoparticles were obtained with acceptable physicochemical properties. In vitro release profile of insulin nanoparticles revealed that the highest solubility of nanoparticles in aqueous media is related to DMEC-Cys nanoparticles. CCD showed that optimized buccal film containing 4% chitosan and 10% glycerol has 5.81?kg/mm2 tensile strength and 2.47?N bioadhesion forces. Results of ex vivo study demonstrated that permeation of insulin nanoparticles through rabbit buccal mucosa is 17.1, 67.89 and 97.18% for chitosan, DMEC and DMEC-Cys nanoparticles, respectively. Thus, this study suggests that DMEC-Cys can act as a potential enhancer for buccal delivery of insulin. 相似文献
13.
Sasan Khalaj Amineh Alireza Fadaei Tehrani Peiman Mosaddegh Aminollah Mohammadi 《Materials and Manufacturing Processes》2015,30(1):93-98
In this paper, a new noncontact ultrasonic magnetic abrasive finishing mechanism is presented. An ultrasonic vibration producer is used to vibrate the permanent magnets. The ferromagnetic steel grits in the created magnetic field form a flexible finishing tool. To take advantage of cavitation collapse pressure, the finishing zone components are immersed in water. The present work also studies the effect of parameters, i.e., time duration for finishing and working gap between magnetic poles and the workpiece on the surface roughness (Ra). The microscopic pictures and the roughness profile diagrams demonstrate the advantages of the proposed method. 相似文献
14.
Elaheh Akbari Mahdi Ghassemi Kakroudi Vahideh Shahedifar 《International Journal of Applied Ceramic Technology》2019,16(4):1329-1336
Fibrous monoliths (FMs) exhibit graceful failure in flexure and have higher toughness values. In this research, a mixture of Al2O3 and SiC as the core and graphite as the shell material of fibers were produced by extrusion-molding technique and after aligning along intended directions (0°, 90°, and 0°/90°) were sintered using the hot-pressing method at the temperature of 1500°C under pressure of 35 MPa for 1 hour. The significance of fibers orientation angle and the cell to cell boundary volume ratio in defining the fracture behavior of the FMs was detected. Because of the extensive crack interactions with graphite cell boundary such as crack deflection and delamination, with increasing cell boundary content from 25 to 30 vol%, the fracture toughness was enhanced. The highest flexural strength (184.8 ± 0.61 MPa) obtained from samples with 0° fibers orientation compared to 0°/90°. Since in the transverse plies (layers with 90° aligning), the properties of matrix phase are dominant, hence the strength in specimens with 0°/90° fibers orientation decreased considerably due to weak graphite matrix phase. In addition, the fracture toughness value increased up to 8.35 ± 0.74 MPa·m1/2 for the unidirectional architecture of (0°) in comparison with cross-ply (0°/90°) architecture. 相似文献
15.
Motevali Bashi Naeini Elaheh Akhoond-Ali Ali Mohammad Radmanesh Fereydoun Koupai Jahangir Abedi Soltaninia Shahrokh 《Water Resources Management》2021,35(14):4855-4875
Water Resources Management - Concerning the various effects of climate change on intensifying extreme weather phenomena all around the world, studying its possible consequences in the following... 相似文献
16.
Elaheh Safaei Langeroodi Narges Samadani Baher Elham 《Protection of Metals and Physical Chemistry of Surfaces》2019,55(1):28-33
Protection of Metals and Physical Chemistry of Surfaces - The present study deals with the application of activated carbon for the adsorptive removal of Cu(II) from its aqueous solutions. This... 相似文献
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Yasin Shabangoli Maher F. El‐Kady Mahrokh Nazari Elaheh Dadashpour Abolhassan Noori Mohammad S. Rahmanifar Xiaojing Lv Cheng Zhang Richard B. Kaner Mir F. Mousavi 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(28)
The surging interest in high performance, low‐cost, and safe energy storage devices has spurred tremendous research efforts in the development of advanced electrode active materials. Herein, the in situ growth of zinc–iron layered double hydroxide (Zn–Fe LDH) on graphene aerogel (GA) substrates through a facile, one‐pot hydrothermal method is reported. The strong interaction and efficient electronic coupling between LDH and graphene substantially improve interfacial charge transport properties of the resulting nanocomposite and provide more available redox active sites for faradaic reactions. An LDH–GA||Ni(OH)2 device is also fabricated that results in greatly enhanced specific capacity (187 mAh g?1 at 0.1 A g?1), outstanding specific energy (147 Wh kg?1), excellent specific power (16.7 kW kg?1), along with 88% capacity retention after >10 000 cycles. This approach is further extended to Ni–MH and Ni–Cd batteries to demonstrate the feasibility of compositing with graphene for boosting the energy storage performance of other well‐known Ni‐based batteries. In contrast to conventional Ni‐based batteries, the nearly flat voltage plateau followed by a sloping potential profile of the integrated supercapacitor–battery enables it to be discharged down to 0 V without being damaged. These findings provide new prospects for the design of high‐performance and affordable superbatteries based on earth‐abundant elements. 相似文献
19.
Jannesari Mohammad Mosaddegh Peiman Kadkhodaei Mahmoud Kasprzak Henryk Jabbarvand Behrouz Mahmoud 《Mechanics of Time-Dependent Materials》2019,23(3):373-384
Mechanics of Time-Dependent Materials - Non-contact tonometers, including ORA and Corvis ST, are not only used to estimate intraocular pressure (IOP) in clinical surveys but are also utilized to... 相似文献
20.
Elaheh Esmaeili Seyyed Amin Rounaghi Wolfgang Gruner Jürgen Eckert 《Advanced Powder Technology》2019,30(10):2032-2041
In the present study, aluminum nitride-carbon (AlN-C) nanocomposites are synthesized through a green, facile and inexpensive mechanochemical route. Well-dispersed nanofluids are prepared by milling of nanocomposite in ethylene glycol (EG) without using any surfactants/ dispersants. The resulting nanofluids have an excellent stability with no obvious sedimentation for at least three months. The results confirm the in-situ polymerization of EG on AlN surface and the formation of hyperbranched glycerol upon milling which in turn stabilizes the particles through a steric effect. The working nanofluids with very low loadings of up to 0.22 vol% of powder exhibit an enhanced heat transfer coefficient (h) of about 24% compared to that of the base fluid in a laminar flow regime (Re = 160). Brownian motion and boundary layer thinning are known as the main mechanisms, causing for this enhancement. 相似文献