Mixed Messages about Mixed Tenure: Do Reviews Tell the Real Story?

Mixed tenure is the predominant development and regeneration strategy and is a key component of UK housing and urban policy. It is purported to provide wide-ranging social, environmental and economic benefits to residents. While there is a large literature on mixed tenure, policy makers are likely to rely on reviews and summaries of the evidence rather than primary studies. But can they rely on such reviews? Using systematic review methods this paper critically appraises recent reviews for the evidence that mixed tenure policies and strategies have achieved any of these expected benefits. Of the six UK reviews of primary studies, most drew on less than half the available primary studies, none provided a critical appraisal of individual studies and made no comment on conflicting evidence between and within studies. While the reviews gave indications of the deficiencies of the evidence base, rather than focus on the implications of these deficiencies, four of the six reviews emphasised the positive effects of tenure mix.     

The olfactory organ of the trout Salmo trutta fario: A novel localization for a progestin receptor

A progestin receptor (PR) has been detected in the olfactory organ of the trout Salmo trutta fario. The specificity of this receptor was high for 17α,20β‐dihydroxy‐4‐pregnen‐3‐one (17α,20β‐DP), but it also bound 17α‐hydroxy‐progesterone (17α‐OHP) and 21‐hydroxyprogesterone (21‐OHP), even when present at low concentrations (10‐fold in relative binding affinity assay). Progesterone (P) competed effectively at much higher concentrations (1,000‐fold in relative binding affinity assay). Immunohistochemical studies carried out with three different monoclonal antibodies against human progesterone receptor (hPR), chicken progesterone receptor hinge region (cPR), and chicken progesterone receptor A/B domain (PR22), revealed that immunoreactivity was present in the epithelium of the olfactory organ of females and males of the trout Salmo trutta fario only against hPR. Western blotting showed two hPR immunoreactive bands of about 62 and 66 kDa. Finally, a portion of the cDNA of about 300 nucleotides extending over the DNA binding domain and the ligand binding domain was cloned and sequenced, revealing a high degree of sequence homology of the PR in Salmo trutta fario with the PR in other teleosts. Microsc. Res. Tech., 2010. © 2009 Wiley‐Liss, Inc.     

New Synthetic Control Charts for Monitoring Process Mean and Process Dispersion

A statistical quality control chart is widely recognized as a potentially powerful tool that is frequently used in many manufacturing and service industries to monitor the quality of the product or manufacturing processes. In this paper, we propose new synthetic control charts for monitoring the process mean and the process dispersion. The proposed synthetic charts are based on ranked set sampling (RSS), median RSS (MRSS), and ordered RSS (ORSS) schemes, named synthetic‐RSS, synthetic‐MRSS, and synthetic‐ORSS charts, respectively. Average run lengths are used to evaluate the performances of the control charts. It is found that the synthetic‐RSS and synthetic‐MRSS mean charts perform uniformly better than the Shewhart mean chart based on simple random sampling (Shewhart‐SRS), synthetic‐SRS, double sampling‐SRS, Shewhart‐RSS, and Shewhart‐MRSS mean charts. The proposed synthetic charts generally outperform the exponentially weighted moving average (EWMA) chart based on SRS in the detection of large mean shifts. We also compare the performance of the synthetic‐ORSS dispersion chart with the existing powerful dispersion charts. It turns out that the synthetic‐ORSS chart also performs uniformly better than the Shewhart‐R, Shewhart‐S, synthetic‐R, synthetic‐S, synthetic‐D, cumulative sum (CUSUM) ln S², CUSUM‐R, CUSUM‐S, EWMA‐ln S², and change point CUSUM charts for detecting increases in the process dispersion. A similar trend is observed when the proposed synthetic charts are constructed under imperfect RSS schemes. Illustrative examples are used to demonstrate the implementation of the proposed synthetic charts. Copyright © 2014 John Wiley & Sons, Ltd.     

Miesian Grids and the Domain of Ink

What happens when you subvert the standardised repetition of the Modernist grid? In Building the Picture, a series of drawings that architect Elena Manferdini produced for an exhibition at the Art Institute of Chicago that ran during the spring and summer of 2015, visual effects and colour were applied to counteract Mies's highly uniform and modular mass-producible systems.     

West Siberian palsa peatlands: distribution,typology, cyclic development,present day climate-driven changes,seasonal hydrology and impact on CO2 cycle

Palsa peatlands occupy extensive areas in Western Siberia which is one of the most paludified flat lowlands of the world. Climatic changes in Western Siberia are more dramatic compared with other northern regions, and changes in palsa landscapes are more notable due to the severe continental climate here. The distribution, peculiarities and climate-indication capacities of West Siberian palsas are poorly known outside Russia. Thus, Western Siberia is one of the most interesting vast natural polygons for studying climate-driven changes in the landscapes. This paper aims to fill the gap in knowledge on West Siberian palsas and their capacity as a climate regulator. We present issues in distribution, typology and cyclic development of palsa peatlands and their actual climate-driven changes. We also analyse the role of palsas in the atmospheric cycle of CO₂, and the hydrology of the palsa regions.     

The potential for gender equality in architecture: an Anglo-Spanish comparison

The practice of architecture is very similar in different national settings despite what may be very different sociological and cultural origins of the profession, the attendant variances in how work is organized and distinctions in equality and gender roles. The aim of this paper is to examine the quest for equality in architecture for women in the UK and Spain reporting the findings of a comparative study into women architects’ careers in the two countries. Within the qualitative paradigm, semi-structured in-depth interviews were carried out with a total of 55 women architects in the UK and Spain. Findings indicate surprising differences in levels and terms of equality for women in the two countries and marked differences in women’s experiences of working as an architect. Women have come to the profession in Spain much later than their British counterparts and, somewhat surprisingly, are present in greater numbers. However, despite there being more of a ‘critical mass’ this has not served to improve their situation; they report much higher levels of discrimination and find it difficult to progress in their careers. Conclusions argue for a stronger approach by the professional bodies to help improve the position of women.     

Phenol decomposition in water cathode of DC atmospheric pressure discharge in air

We studied phenol decomposition in aqueous solution under the action of DC discharge at atmospheric pressure in air. The decomposition efficiency was 0.017 molecules per 100 eV. When the kinetics of forming destruction products was studied in detail, the peculiarities of air plasma action were revealed for the first time. Plasma action not only results in the formation of oxygen-containing products, which are usually formed under oxygen plasma action (hydroxyhenols, carboxylic acids, aldehydes), but also the formation of nitro phenols. The treatment is accompanied by hydrogen peroxide formation, a pH decrease, and nitric and nitrous acids formation. We also discussed the possible mechanism of the processes and the role of some active species in chemical transformations after determining some parameters of the discharge.     

Solid-Phase Microextraction (SPME) of Pyrazines in Model Reaction Systems

Headspace solid-phase microextraction (HS-SPME) combined with gas chromatography (GC) was used for isolating and analysing pyrazines formed in a model system. This system consisted of an aqueous mixture of glucose, glycine and sodium hydroxide. Pyrazine formation was accelerated by heating in a microwave oven. Results were compared with our earlier ones using conventional techniques for isolation of pyrazines. HS-SPME-GC showed several advantages over traditional methods. The method is rapid, sensitive, easy to use and reproducible. Headspace and liquid of the model reaction were extracted and the results obtained using headspace sampling showed good agreement with the methylene chloride extraction method. In all cases, coefficients of variation of 5% or lower were obtained when the SPME extraction time was consistent.     

Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies

Astrocytes are very versatile cells, endowed with multitasking capacities to ensure brain homeostasis maintenance from brain development to adult life. It has become increasingly evident that astrocytes play a central role in many central nervous system pathologies, not only as regulators of defensive responses against brain insults but also as primary culprits of the disease onset and progression. This is particularly evident in some rare leukodystrophies (LDs) where white matter/myelin deterioration is due to primary astrocyte dysfunctions. Understanding the molecular defects causing these LDs may help clarify astrocyte contribution to myelin formation/maintenance and favor the identification of possible therapeutic targets for LDs and other CNS demyelinating diseases. To date, the pathogenic mechanisms of these LDs are poorly known due to the rarity of the pathological tissue and the failure of the animal models to fully recapitulate the human diseases. Thus, the development of human induced pluripotent stem cells (hiPSC) from patient fibroblasts and their differentiation into astrocytes is a promising approach to overcome these issues. In this review, we discuss the primary role of astrocytes in LD pathogenesis, the experimental models currently available and the advantages, future evolutions, perspectives, and limitations of hiPSC to study pathologies implying astrocyte dysfunctions.