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101.
Maria A. Papadaki Ippokratis Messaritakis Oraianthi Fiste John Souglakos Eleni Politaki Athanasios Kotsakis Vassilis Georgoulias Dimitrios Mavroudis Sofia Agelaki 《International journal of molecular sciences》2021,22(2)
We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-line chemotherapy. CellSearch revealed the detection of ≥1 CTCs in 41.9%, 40.9%, and 16.7% of patients at baseline, post-1st, and post-2nd treatment cycle, respectively, and of ≥5 CTCs in 11.6%, 9.1%, and 5.6%, respectively. CEACAM5mRNA+ CTCs were detected in 29.3% and 16% of patients pre- and post-treatment, respectively. The positivity concordance between the two assays was 2.2%. CTC-detection by CellSearch (≥5 CTCs: p = 0.004), CEACAM5mRNA (p = 0.010), or by any assay (p = 0.000) was associated with disease progression. Reduced survival was demonstrated for patients harboring ≥5 CTCs (progression-free survival; PFS: p = 0.000; overall survival; OS: p = 0.009), CEACAM5mRNA+ CTCs (PFS: p = 0.043; OS: p = 0.039), and CTCs by any assay (PFS: p = 0.005; OS: p = 0.006, respectively). CTC-detection by any assay independently predicted for increased risk of relapse (hazard ratio; HR: 3.496; p = 0.001) and death (HR: 2.866; p = 0.008). CellSearch-positivity either pre-, post-1st, or post-2nd cycle, was predictive for shorter PFS (p = 0.036) compared to negativity in all time points. Persistent CEACAM5mRNA-positivity pre- and post-treatment was associated with reduced PFS (p = 0.036) and OS (p = 0.026). In conclusion, CTC detection and monitoring using the CellSearch and CEACAM5mRNA assays provides valuable and complementary clinical information for chemo-naïve advanced or metastatic NSCLC. 相似文献
102.
Eleni Patouni Sophie Gault Markus Muck Nancy Alonistioti Konstantina Kominaki 《电信纪事》2007,62(9-10):1099-1120
The Autonomic Communications concept forms one promising solution to accommodate the increased complexity of legacy and emerging systems, fostering the automation and minimizing the need for human intervention. This notion implies the introduction of advanced mechanisms for autonomic decision making and self-configuration. The focus of this work is on the introduction of an advanced reconfiguration framework for the support of the following functionalities: i) efficient strategies of terminal attachment to heterogeneous wireless systems are proposed dependent on the evaluation of input stimuli from the surrounding telecom environment. ii) it is shown how to enable optimized selection and attribution of resources, iii) the application of new device configuration is examined, proposing a framework for dynamic protocol stack adaptation. It is indeed necessary to introduce a framework that will enable, policy based reconfiguration decisions supporting dynamic and optimal discovery, download and replacement of necessary protocol functionality. In this context, legacy management and control mechanisms should be enriched with such features operating in either terminal or network equipment. Namely, this contribution discusses cognitive reconfiguration management issues by introducing two basic reconfiguration units encapsulated in a unified management and control architecture: i) the component based protocol stack reconfiguration framework and ii) the resource usage optimization unit. Simulation and performance results presented in the paper prove the technical feasibility of the proposed mechanisms as well as the optimization of reconfiguration actions. 相似文献
103.
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105.
Rebecca Kokkinofta Naso Economidou Eleni Tzioni Katerina Damianou Konstantina Poulli Chara Savvidou Charalambos Louka Popi Kanari 《化学与化工:英文版》2014,(2):101-107
The authenticity of 91 wines produced in Cyprus from both indigenous and other vine varieties were investigated by a holistic approach, using, advanced technology such as SNIF-NMR (site-specific natural isotopic fractionation-nuclear magnetic resonance) and 1R-MS (isotope ratio-mass spectrometry) for the determination of the stable isotopes and ICP (inductively coupled plasma spectroscopy) for some heavy metals. The spectroscopic characteristics were evaluated statistically using different chemometric methods. The dependency of the D/H (deuterium/hydrogen) ratio of the methylene site in the ethanol molecule (D/H)ll and also theδ ^18O values of the wine water, were the most useful discriminators. Isotopic results allow us to have a complete idea about the regional variability of the isotopes. Among the metals, Ni followed by Pb was the ones with the highest discrimination value. The determined concentrations of Pb, Ni, Cr and Cd that are related to the safety of wines were within the acceptable limits that have been established by the OIV (international organization of vine and wine) or comparable with the results of the wines of other European countries. The study of the correlation between the load of heavy metals and isotopes in wines showed a dependence on the grape variety but not the geographical location of the vineyard. This is probably due to the close proximity of wine regions in Cyprus. 相似文献
106.
107.
UMLDiff is a heuristic algorithm for automatically detecting the changes that the logical design of an object-oriented software system
has gone through, as the subject system evolved from one version to the next. UMLDiff requires as input two models of the logical design of the system, corresponding to two of its versions. It produces as output
a set of change facts, reporting the differences between the two logical-design versions in terms of (a) additions, removals,
moves, renamings of model elements, i.e., subsystems, packages, classes, interfaces, attributes and operations, (b) changes
to their attributes, and (c) changes to the relations among these model elements. In this paper, we detail the underlying
metamodel, the UMLDiff algorithm and its heuristics for establishing lexical and structural similarity. We report on our experimental evaluation
of the correctness and robustness of UMLDiff through a real-world case study. 相似文献
108.
Elli?GeorgiadouEmail author Eleni?Berki Maria?del Brezo Cordero Margaret?Ross Geoff?Staples 《Software Quality Journal》2005,13(1):31-69
This paper provides evidence that it is possible to migrate structured system designs to UML models. Legacy structured designs can be converted to object-oriented systems without losing data or functionality. The reason for choosing UML is that it is the new standard notation, which tries to build on and integrate object-oriented notations. Extracts from a case study are presented together with the proposed guidelines for the re-engineering process. 相似文献
109.
Rudd NC Cannan S Bitziou E Ciani I Whitworth AL Unwin PR 《Analytical chemistry》2005,77(19):6205-6217
The application of fluorescence confocal laser scanning microscopy (CLSM) to quantify three-dimensional pH gradients near electrode surfaces is described. The methodology utilizes a trace quantity of a fluorescent dye, fluorescein, in solution, which fluoresces strongly above pH 6.5, to map the pH adjacent to various ultramicroelectrodes undergoing electrochemical processes that lead to pH changes. The experimental fluorescence profiles, determined by CLSM, have been compared to models by solving the underlying mass transport equations, including the effect of natural convection, using the finite element method. The methodology has been validated through studies of the galvanostatic reduction of water at both disk and ring ultramicroelectrodes. The fluorescence profiles were found to be highly sensitive to both the initial bulk solution pH and applied current in a predictable fashion. The potentiostatic reduction of oxygen has been investigated at 25- and 10-microm-diameter platinum electrodes to confirm the effective number of electrons transferred in the reaction. Finally, the application of this methodology to observe defects in microelectrode arrays, particularly those that cannot be seen by optical microscopy, is described. 相似文献
110.
Zampronio CG Giannakopulos AE Zeller M Bitziou E Macpherson JV Derrick PJ 《Analytical chemistry》2004,76(17):5172-5179
Electrospray ionization (ESI) is extensively used in the analysis of biological compounds; yet some fundamental properties of this technique are not completely understood. It is widely recognized that care should be exercised when noncovalent complexes are being studied by ESI, since weak noncovalent binding can be broken or formed during the desolvation process. In the present work, spectra from the noncovalent complex, vancomycin/diacetyl-L-lysyl-D-alanyl-D-alanine, obtained from ESI and from nanoelectrospray ionization (nanoESI), have been compared. The results indicated that the milder desolvation conditions arising as a result of the smaller sizes of droplets produced in the nanoESI source attenuated effects upon weak bonds in the desolvation process. The association constant values calculated from the relative peak intensities suggest that, when using ESI, the analyzed noncovalent complex dissociated in the condensed phase during the spraying process. The influences of experimental parameters such as tip diameter and coating for nanoESI needles were investigated. Principal component analysis, a multivariate analysis method, was applied to achieve a better evaluation of the spectra obtained using different needle diameters and coatings for the analysis of the noncovalent complex vancomycin/diacetyl-L-lysyl-D-alanyl-D-alanine. It was found that 2-microm tip diameter resulted in more reproducible spectra than the larger tip diameters tested (6-20 microm). 相似文献